One of the few reasons to read Xitter: Lee Cronin’s whines

Crank meltdown in progress. Leroy Cronin, who published that ridiculous “assembly theory” article in Nature has been struggling for the last few ways to cope with the ridicule coming his way.


Make a theory at the intersection of evolutionary biology, theoretical physics, complexity theory, & prebiotic chemistry = x 4 the ‘normal’ trolling fun. I love the virtue signalling & the fact they clearly have not even read the paper which is no excuse as it is open access.😂

‘Everyone who disagrees with me is a troll!’ is not the triumphant comeback you think it is. Yes, it’s a theory that combines a lot of disciplines, I agree. But has he considered that maybe the reason he’s getting so much pushback is that people who actually know something about each of those disciplines is saying that the authors don’t understand how the discipline works? I can say that his paper didn’t get evolutionary biology at all right, so now I’m wondering if he also got theoretical physics, complexity theory, and prebiotic chemistry just as wrong.


Gosh first the complexity theorists, then prebiotic chemists followed by the theoretical physicists, & evolutionary biologists. Is that all? Now the creationists are trolling me also. 🤷

I haven’t seen the creationists responding to assembly theory, but now I want to. Not hard enough to actually go digging, unfortunately.


Paradigm shifts involve 1) confusion & anger followed by 2) pronouncements on how obvious it is with the final 3) it has already been done or they thought of it before & it was trivial.

Yikes. The kooks always claim to be leading a ‘paradigm shift’ and start quoting Kuhn.

Here’s another famous quote, this time from Carl Sagan.

“But the fact that some geniuses were laughed at does not imply that all who are laughed at are geniuses. They laughed at Columbus, they laughed at Fulton, they laughed at the Wright brothers. But they also laughed at Bozo the Clown.”

The fact that your ideas are laughed at is not evidence that you are correct.


I love critical feedback because it helps improve stuff & I also get excited when people get ‘triggered’ scientifically as it means something REALLY interesting is shifting. It ain’t pretty but it might accelerate science. #AssemblyTheory

Also, the fact that experts are triggered and reject your theory is not interesting, and doesn’t mean you’ve made a productive change in the world. Creationists trigger me too, that doesn’t validate creationism.


I’m happy to be wrong as I learn more. I like to be almost right occasionally so I can dig deeper. I also want to be bold & honest about it. Science is about taking risks, not beating people up that offend your world view.

No one is offended. No one is beating people up. Cronin is being told that his ideas are wrong, which is what we’re supposed to do.

He’s feeling resentful about being corrected, nothing more. Well, also there should be some shame at publishing such a crappy article in a prestigious journal.

Finally, he reposts something from a supporter:


Absolutely wild to open Twitter and learn that evolutionary biologists think the origin of life is either solved or a non-problem.

No one has said that. The origin of life is not solved and is most definitely a problem of interest. The catch is that assembly theory does not solve any of the problems anyone is wrestling with, and doesn’t seem to solve much of anything.

This is all reminding me of how Dr Wolfe-Simon reacted defensively to criticisms of her claim that life can substitute arsenic for phosphorus. Things got loud back in 2010, and she was insistent that she made a great discovery, but when was the last time you heard about arsenic life? The idea was dead within a year.

Let’s check back in Fall of 2024 and see how Cronin’s theory is holding up.

Kill them all, let god sort them out

I’ve heard this sort of call to action many times before. Here’s Marco Rubio with his solution to the Israel/Palestine problem.

I don’t think there’s any way Israel can be expected to coexist or find some diplomatic offramp with these savages. I mean, these are people, as you have been reporting and others have seen, that deliberately targeted teenage girls, women, children, the elderly, not just for rape and murder, but then dumping their bodies off in the streets of Gaza, where the crowds can then defile their lifeless bodies.
I mean, just horrifying things. And I don’t think we know the full extent of it yet. I mean, there’s more to come in the days and weeks ahead. You can’t coexist. They have to be eradicated.

“Savages.” “They have to be eradicated.” What a familiar sentiment! And what a deplorable perspective.

Notice that Tapper pointed out that a million of the Palestinians in the Gaza Strip are children, and Rubio just ignored that reality to call for their murder. I agree that the individuals who executed that horrific attack were evil people who need to be caught and punished, that there should be no forgiveness for their crimes, but that’s very different from pointing at an entire people, most of whom had nothing to do with the attack, and declaring that they all, women, children, the elderly, need to be eradicated. Wrong. They all deserve to live happy lives, a right they’ve been denied, and only the guilty need to be removed from civil society.

I’m just afraid that Rubio’s attitude is going to be popular among the right-wing fascists. When horrors are piling up on horrors, you don’t end the cycle by adding fresh horrors to the pile.

Signs of hope

About 15 years ago, Minnesota was dealing with a bunch of ignorant radicals who were packing school boards, and had even captured the position of educational commissioner in the form of Cheri Yecke. It was ugly. I was attending school board meetings that featured train of young earth creationists standing up to parrot nonsense…but, fortunately, we also had genuine grass roots people standing up to oppose them. We’ve still got wretched right wingers filling school boards, but at least I think we totally crushed the creationist insurgence here, and Yecke is long gone.

Now, though, the US (not so much Minnesota) is dealing with another group of astro-turfing assholes, Moms for Liberty. There are signs that they are getting desperate. Would you believe Moms for Liberty was trying to build a claque to attend a school board meeting? They were recruiting “talented clappers” to pack the audience.

It’s not working.

What’s happening instead is that the general public is getting fired up. They hate those arrogant Karens. They’ve recently won school board elections, but like the creationists, as word gets around, the public rises up and notices and starts firing back.

Most of the attendees saw that appeal as a minor victory, or at least as evidence that they were gaining ground in the battle for control over the school district — one of hundreds of similar battles unfolding all over the country. Yes, the Pennridge school board was dominated by far-right members, one of whom had been present in Washington for Donald Trump’s “Stop the Steal” rally-turned-riot on Jan. 6, 2021. Yes, at least five of the nine board members were linked to Moms for Liberty, a right-wing “astroturf” organization that has orchestrated a national campaign to remake public education along arch-conservative and anti-intellectual lines. But Pennridge board meetings for months had been dominated by outraged parents speaking out against the Moms for Liberty incursion and the board majority’s apparent agenda. Conservative forces were sufficiently worried about the optics, it appeared, that they were eager to pull in “talented clappers” from outside the community.

A tightly packed group of Moms for Liberty supporters did indeed show up, huddled together in a few rows of seats. Their mood could best be described as “glowering.” These were not exactly the “joyful warriors” that Moms for Liberty proudly proclaims fights on their behalf. That term would better fit the majority of attendees at Pennridge High that night, who needed no coaxing to whoop and applaud as one speaker after another took the mic, defending the basic freedom to read whatever books one wants, and denouncing the ahistorical and misleading curriculum that conservative board members wanted to force upon the district’s teachers.

This is news that gives me a little optimism. I think the public at large wants to do what is right, even as a minority of hateful, motivated scumbags exploit the system to secure some degree of power. Temporarily.

Today is Indigenous Peoples’ Day

And I don’t want to hear you say otherwise. We don’t celebrate greedy genocidal monsters around these here parts, we honor the people who lived on this land.

For the third year running, a U.S. president has officially recognized Indigenous Peoples’ Day.

President Biden issued a proclamation on Friday to observe Monday, Oct. 9, as a day to honor Native Americans, their “resilience, strength, and perseverance” and “determination to preserve cultures, identities, and ways of life,” even as they have faced “violence and devastation,” he said.

Assembly Theory is Ontogenetic Depth relabeled, nothing more, and is just as useless

How exactly did this dreck, Assembly theory explains and quantifies selection and evolution, get published in Nature?

It’s a stunningly bad paper to be published in such a prestigious journal. Let’s dissect that abstract, shall we?

Scientists have grappled with reconciling biological evolution1,2 with the immutable laws of the Universe defined by physics.

This makes no sense. Evolutionary biologists have not had any problem with physical laws — it has always been assumed, as far as I know, that biology fits within the framework of chemistry and physics. What grappling? Have biologists been proposing theories that violate physics, and they didn’t tell me?

The citations to back up that outré claim are Stuart Kauffman, who can get a little weird but not that weird, and Ryan Gregory, whose papers I’ve used in class, and is probably a bit annoyed at being told his work supports that ridiculous claim.

These laws underpin life’s origin, evolution and the development of human culture and technology, yet they do not predict the emergence of these phenomena.

Sure. Emergent properties exist. We know you can’t simply derive all of biology from Ideal Gas Law. So far, nothing new.

Evolutionary theory explains why some things exist and others do not through the lens of selection.

Uh-oh. Just selection? Tell me you know nothing of evolutionary biology without saying you don’t know anything about evolutionary biology.

To comprehend how diverse, open-ended forms can emerge from physics without an inherent design blueprint, a new approach to understanding and quantifying selection is necessary3,4,5.

Here it comes, more bad theorizing. It is implicit in evolution that there is no “inherent design blueprint,” so where did these authors get the idea that design was a reasonable alternative? They don’t say. This is simply another imaginary controversy they’ve invented to make their theory look more powerful.

We don’t need a new approach to selection. To support that, they cite Charles Darwin (???) and Sean B. Carroll, and a fellow named Steven Frank, whose work I’m unfamiliar with. A quick search shows that he applies “evolutionary principles to the biochemistry of microbial metabolism,” which doesn’t sound foreign to standard biology, although he does throw the word “design” around a lot.

But here we go:

We present assembly theory (AT) as a framework that does not alter the laws of physics, but redefines the concept of an ‘object’ on which these laws act. AT conceptualizes objects not as point particles, but as entities defined by their possible formation histories. This allows objects to show evidence of selection, within well-defined boundaries of individuals or selected units.

Again, what biological theory has ever been proposed that alters the laws of physics? They keep touting this as a key feature of their model, that it doesn’t break physics, but no credible theory does. This talk of formation histories is nothing revolutionary, history and contingency are already important concepts in biology. Are they really going to somehow quantify “assembly”? They’re going to try.

We introduce a measure called assembly (A), capturing the degree of causation required to produce a given ensemble of objects. This approach enables us to incorporate novelty generation and selection into the physics of complex objects. It explains how these objects can be characterized through a forward dynamical process considering their assembly.

I’ve heard this all before, somewhere. A new term invented, a claim of a novel measure of the complexity of a pathway, a shiny new parameter with no clue how to actually measure it? This is just ontogenetic depth! Paul Nelson should be proud that his bad idea has now been enshrined in the pages of Nature, under a new label. I did a quick check: Nelson is not cited in the paper. Sorry, Paul.

Here is all assembly theory is: You count the number of steps it takes to build an organic something, and presto, you’ve got a number A that tells you how difficult it was to evolve that something. That’s it. Biology is revolutionized and reconciled with physics. It’s just that stupid.

a–c, AT is generalizable to different classes of objects, illustrated here for three different general types. a, Assembly pathway to construct diethyl phthalate molecule considering molecular bonds as the building blocks. The figure shows the pathway starting with the irreducible constructs to create the molecule with assembly index 8. b, Assembly pathway of a peptide chain by considering building blocks as strings. Left, four amino acids as building blocks. Middle, the actual object and its representation as a string. Right, assembly pathway to construct the string. c, Generalized assembly pathway of an object comprising discrete components.

I told you, it’s just ontogenetic depth, with basic math. Here’s how to calculate A:

All you have to do is recursively sum the value of A for each object in the series, and you get the value of A for the whole! How you calculate the value of A for, say, acetate or guanine or oxaloacetic acid or your nose or a lobe of your liver is left as an exercise for the reader. It is also left as an exercise for the reader to figure out how A is going to affect their implementation of evolutionary biology.

By reimagining the concept of matter within assembly spaces, AT provides a powerful interface between physics and biology. It discloses a new aspect of physics emerging at the chemical scale, whereby history and causal contingency influence what exists.

I read the whole thing. I failed to see any new aspect of physics, or any utility to the theory at all. I don’t see any way to apply this framework to evolutionary biology, or what I’d do if I could calculate A for one of my spiders (fortunately, I don’t see any way to figure out the A of Steatoda triangulosa, so I’m spared the effort of even trying.)

The primary author, Leroy Cronin, a chemistry professor at the University of Glasgow, acknowledges that the work was funded by the John Templeton Foundation. Quelle surprise!

I honestly don’t understand how such a steaming pile managed to get past the editors and reviewers at Nature. It should have been laughed away as pure crank science and tossed out the window. There has to have been a lot of steps where peer review failed…maybe someone should try to calculate the assembly value for getting a paper published in Nature so we can figure out how it happened.

Sharma, A., Czégel, D., Lachmann, M. et al. Assembly theory explains and quantifies selection and evolution. Nature (2023). https://doi.org/10.1038/s41586-023-06600-9

Can somebody explain this to me?

The Palestinians have a tiny amount of territory, the Gaza Strip and the West Bank, that has been under Israeli control since 1968. Israel controls the air space, all of the entry points, and is allowed to let its military freely enter. All utilities, water, electricity, communications, etc. in these territories is completely controlled by Israel. Israeli settlers have been colonizing the territories. The Palestinians are treated as residents of a vassal state, with limited freedoms, and occasionally Israeli soldiers bulldoze a home or shoot a citizen.

The US has given Palestine $235 million in aid, mostly dedicated to supporting refugees. The US has given Israel almost $4 billion in aid, virtually entirely dedicated to propping up their military.

The US has responded to a terrorist attack in Israel by promising to send more aid, more arms, to Israel. They’re also moving an aircraft carrier to the coast in support.

This is insane.

Israel does not need more money, arms, and encouragement to continue their oppression of the Palestinian people. It is inarguably horrible and criminal that Hamas militants murdered civilians, and I cannot excuse that; but neither can I excuse the decades of brutal oppression of Palestinians by Israel. These are criminal acts all around, and none can be forgiven.

The only reasonable answer, though, is to give Palestinians greater freedom and autonomy. They’re turning to violent assholes in Hamas because there is no alternative, and because Israel has become increasingly tyrannical. The US ought to be working to moderate the relationship, not giving Israel the tools and the encouragement to commit genocide. That’s all the current pattern of behavior can end in, in the violent, bloody destruction of an entire people.

Current US policy is enabling that genocide.

Nightmare nest

This thing is hanging in a tree near where I walk on the way to the lab. It’s bigger than my head!

That’s actually what I think when I walk by: “What if that fell off and landed on my head and I had to run around waving my arms?” A childhood watching Saturday morning cartoons has given me that expectation.

Don’t trust self-driving cars

I think I can scratch a self-driving car off my Christmas list for this year…and for every year. I can always use more socks, anyway. The Washington Post (owned by another tech billionaire) has a detailed exposé of the catastrophic history of so-called autonomous vehicles.

Teslas guided by Autopilot have slammed on the brakes at high speeds without clear cause, accelerated or lurched from the road without warning and crashed into parked emergency vehicles displaying flashing lights, according to investigation and police reports obtained by The Post.

In February, a Tesla on Autopilot smashed into a firetruck in Walnut Creek, Calif., killing the driver. The Tesla driver was under the influence of alcohol during the crash, according to the police report.

In July, a Tesla rammed into a Subaru Impreza in South Lake Tahoe, Calif. “It was, like, head on,” according to a 911 call from the incident obtained by The Post. “Someone is definitely hurt.” The Subaru driver later died of his injuries, as did a baby in the back seat of the Tesla, according to the California Highway Patrol.

Tesla did not respond to multiple requests for comment. In its response to the Banner family’s complaint, Tesla said, “The record does not reveal anything that went awry with Mr. Banner’s vehicle, except that it, like all other automotive vehicles, was susceptible to crashing into another vehicle when that other vehicle suddenly drives directly across its path.”

Right. Like that ever happens. So all we have to do is clear the roads of all those other surprising vehicles, and these self-driving cars might be usable. That’s probably Elon Musk’s end goal, to commandeer the entirety of the world’s network of roads so that he can drive alone.

Speaking of Musk, he has a long history of lying about the capabilities of his autopilot system.

Tesla CEO Elon Musk has painted a different reality, arguing that his technology is making the roads safer: “It’s probably better than a person right now,” Musk said of Autopilot during a 2016 conference call with reporters.

Musk made a similar assertion about a more sophisticated form of Autopilot called Full Self-Driving on an earnings call in July. “Now, I know I’m the boy who cried FSD,” he said. “But man, I think we’ll be better than human by the end of this year.”

Lies. Lies, lies, lies, that’s all that comes out of that freak’s mouth. If you want more, Cody has a new video that explains all the problems with this technology. I know, it’s over an hour long, but the first couple of minutes contains a delightful montage of Musk making promises over the years, all of which have totally failed.

Can we just stop this nonsense and appreciate that human brains are pretty darned complex and there isn’t any AI that is anywhere near having the flexibility of a person? Right now we’re subject to the whims of non-scientist billionaires who are drunk on the science-fantasies they read as teenagers.

Now the spiders are leaving

Oh no. I was laughing at this very silly woman who claims the emergency phone alert system test the other day made everyone’s menstrual flow start. She has an n of 1, herself, and she admits that she doesn’t track her periods, so I don’t see the point. She doesn’t have any evidence at all for this claim, and I don’t see how a cell phone signal could trigger menstruation, so she lacks even a hypothetical mechanism.

And then we get to her chilling last line…

I checked the lab. No, they’re all there and are fine.

I’m also not menstruating.