Deep homologies in the pharyngeal arches

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PvM at the Panda’s Thumb has already written a bit about this issue in the article “Human Gland Probably Evolved From Gills”, but I’m not going to let the fact that I’m late to the party stop me from having fun with it. This is just such a darned pretty story that reveals how deeply vertebrate similarities run, using multiple lines of evidence.

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Cephalopod gnashers

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Cephalopods can inflict a nasty bite. On their underside, at the conjunction of their arms, they have a structure called the beak which does look rather like a bird’s beak, and which can close with enough force to crush shellfish. Many also dribble toxins into the wound that can cause pain, tissue necrosis, and paralysis. They aren’t the best animals to play with.

If you think about it, though, cephalopods don’t have a rigid internal skeleton. How do they get the leverage to move a pair of sharp-edged beaks relative to one another, and what the heck are they doing with a hard beak anyway? There’s a whole paper on the anatomy of just the buccal mass, the complex of beak, muscle, connective tissue, and ganglia that powers the cephalopod bite.

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Whose side are you on, Flatow?

I’ve been listening to Bethell vs. Mooney on Science Friday, and I’ve come to one conclusion: I really need to slap Ira Flatow. Repeatedly. And maybe kick him a few times, too.

He was playing right into Bethell’s hands. Bethell was rambling and vague, and he went on and on, and Flatow fed into it. Mooney had to interrupt several times and demand a chance to rebut (and good for him—he was on the attack, as he needed to be), and at least once Flatow stopped Mooney for a commercial and then asked Bethell to follow up afterwards.

Worse, Flatow wouldn’t allow any depth. They’d start getting into HIV and Bethell’s denial, and just as Mooney was getting into it, he’d say, “Now we need to talk about global warming!” Come on, FOCUS. The strengths of science come into play when we have a chance to dig deep and actually grapple with the issues; Bethell is a superficial flibbertigibbet who knows nothing, and this show gave him a forum for his usual unsupported pronouncements of doubt.

Grrr. Mooney was appropriately assertive, but it sounds like we need to go to new levels of aggression: next interview, bring duct tape and a clothesline. Shut the interviewer up, and charge right into the data. I can’t believe Flatow let Bethell get away with that crap.

Polar lobes and trefoil embryos in the Precambrian

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The diagram above shows the early cleavages of the embryo of the scaphopod mollusc, Dentalium. You may notice a few peculiarities: the first cleavage is asymmetric, producing a cell called AB and a larger sister cell, CD. Before the second division, CD makes a large bulge, called a polar lobe, and it almost looks like it’s a three-cell stage—this is called a trefoil embryo, and can look a bit like Mickey Mouse. The second division produces an A, a B, a C, and a D cell, and there’s that polar lobe, about as large as the regular cells, so that it now resembles a 5-cell embryo. What’s going on in these animals?

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Maternal effect genes

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Maternal effect genes are a special class of genes that have their effect in the reproductive organs of the mutant; they are interesting because the mutant organism may appear phenotypically normal, and it is the progeny that express detectable differences, and they do so whether the progeny have inherited the mutant gene or not. That sounds a little confusing, but it really isn’t that complex. I’ll explain it using one canonical example of a maternal effect gene, bicoid.

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Don’t delay, donate!

We have received most excellent news from Seed: notice that challenge bar to the left, where I (and many other science bloggers) are asking you to donate to public education? We’re doing great—my challenge has gathered over a thousand dollars so far, all to help out teachers and schoolkids—but now Seed has announced that they will match the total donations, up to $10,000. Double your money!

I’ve set a goal of raising $2000 for teachers, but I’ve got a dozen projects listed, and they’re going to need more than that if all are to be fully funded. If I hit the goal, don’t stop—you can keep contributing. Janet has a list of the other participants, too, so if you want to spread the joy around some more, check out the others.

Oh, and everyone should shout out, “Yay, Seed!” right now. It’s the right thing to do, even if it startles other people in the office or coffee shop.

Science swirling down the drain

Lots of stuff about the intersection of science and politics in the US today—here are three things to read over breakfast.

  • Bruce Sterling suggests that American science is experiencing creeping Lysenkoism, and reports that “the Bush administration has systematically manipulated scientific inquiry into climate change, forest management, lead and mercury contamination, and a host of other issues.” He predicts a rather grim end for our science and science policy.

    Before long, the damage will spread beyond our borders. International scientific bodies will treat American scientists as pariahs. This process has already begun in bioethics, meteorology, agriculture, nuclear science, and medicine, but doubts will spread to “American science” generally.

    It’s not a happy piece. Read it anyway.

  • Chris Mooney is surprised at the longevity of the critiques of Republican “science”: he says that “a similar pattern–ignore experts, favor ideologues–has been followed by the administration on any number of other science issues, ranging from global warming to the morning after pill,” and seems most impressed by the fact that these problems are being pointed out, over and over again. Where Sterling sees looming disaster, though, Mooney sees some hope: not everyone is blind to what the Bushites are doing, and science policy is becoming an important issue.

    But now I realize something more: These questions are proof positive that those who are worried about the politics of science nurture their concern within a much broader context. These Americans are thinking: As science goes, so goes the nation. On some level, the science community has always known that. What’s new is that now, we have a heck of a lot of company.

    Now we just have to get all that company motivated to campaign and vote.

  • Darksyde discusses an bill to protect scientific whistleblowers, people who come forward to politicized, ideological tampering with the science coming out of our premier federal research institutions, like NOAA. As he says, “Once again, the GOP preferred to ignore reality and opt for wishful thinking”: it was killed by the Republicans. The author of the bill, Rep. Brad Miller, (D-North Carolina), was online responding to comments, if you’d like to hear straight from the source.

    I think Mooney is right, that the public can see the damage being done to our reputation and the erosion of America’s science and engineering skill set, but there’s the obstacle—as long as the Republicans are in power, we’re not going to be able to slow the destruction.