I guess I’m in hiding

I’ve gotten a few calls from the university today — I was worried that something important had happened to my lab, but no, administrators were just concerned because of this event happening this evening.

Yeah, those a-holes are speaking at my university, led by Knowles, one of the negligible intellects at the Daily Wire who has been on the anti-trans bandwagon for a while now, and with little else to say. I imagine he’ll be on the stage at the Twin Cities campus trying to stir up a little hate this evening, and in an over-abundance of caution, the administration is asking to temporarily suppress my information on the university web site, with my consent.

I agreed. I can’t run away very fast nowadays, so better safe than sorry.

They should have called this the “American Go Away Tour.”

A totally predictable AI delusion

Mark Zuckerberg has sunk billions into AI, and a whole slew of grifters have been doing likewise, so I really appreciate a good pratfall. He set up an elaborate demo of his Meta AI, stood on a stage, brought up a chef, and asked the AI to provide instructions…to make a steak sauce. Cool. Easy. I could open a cookbook or google a recipe and get it done in minutes, but apparently the attempt here was to do it faster, easier, better with a few vocal requests.

On a stage contrived to make Zuckerberg look so small

Except it didn’t work.

“You can make a Korean-inspired steak sauce using soy sauce, sesame oil…” begins Meta AI, before Mancuso interrupts to stop the voice listing everything that happens to be there. “What do I do first?” he demands. Meta AI, clearly unimpressed by being cut off, falls silent. “What do I do first?” Mancuso asks again, fear entering his voice. And then the magic happens.

“You’ve already combined the base ingredients, so now grate a pear to add to the sauce.”

Mancuso looks like a rabbit looking into the lights of an oncoming juggernaut. He now only has panic. There’s nothing else for it, there’s only one option left. He repeats his line from the script for the third time.

“What do I do first?”

There’s then audience laughter.

“You’ve already combined the base ingredients, so now grate the pear and gently combine it with the base sauce.”

Poor Mark, publicly embarrassed in a demo that was all designed to make a trivial, rigged display, and it flopped.

What’s so joyous about this particular incident isn’t just that it happened live on stage with one of the world’s richest men made to look a complete fool in front of the mocking laughter of the most non-hostile audience imaginable…Oh wait, it largely is that. That’s very joyous. But it’s also that it was so ludicrously over-prepared, faked to such a degree to try to eliminate all possibilities for error, and even so it still went so spectacularly badly.

From Zuckerberg pretending to make up, “Oh, I dunno, picking from every possible foodstuff in the entire universe, what about a…ooh! Korean-inspired steak sauce!” for a man standing in front of the base ingredients of a Korean-inspired steak sauce, to the hilarious fake labels with their bold Arial font facing the camera, it was all clearly intended to force things to go as smoothly as possible. We were all supposed to be wowed that this AI could recognize the ingredients (it imagined a pear) and combine them into the exact sauce they wanted! But it couldn’t. And if it had, it wouldn’t have known the correct proportions, because it would have scanned dozens and dozens of recipes designed to make different volumes of sauce, with contradictory ingredients (the lack of both gochujang and rice wine vinegar, presumably to try to make it even simpler, seems likely to not have helped), and just approximated based on averages. Plagiarism on this scale leads to a soupy slop.

What else would you expect? They’re building machines that are only good for regurgitating rearranged nonsense, and sometimes they only vomit up garbage.

False idol

Republicans are insane.

Republican lawmakers in Oklahoma introduced legislation this week that would require every public university in the state to construct “a Charlie Kirk Memorial Plaza”, with a statue of the assassinated Republican activist and a sign calling him a “modern civil rights leader”, or pay monthly fines.

The proposed legislation comes as conservatives pay tribute to the murdered activist and podcaster, whose life will be commemorated by the president at a service in Arizona on Sunday, by comparing him to martyred political and spiritual leaders, including Martin Luther King Jr and Saint Paul.

The Oklahoma bill, sponsored by state senators Shane Jett and Dana Prieto, specifies that the memorial site must be in “a prominent area” on the main campus of every institution of higher education in the state system, and must include “a statue of Charlie Kirk sitting at a table with an empty seat across from him” or one of Kirk and his wife holding their children. Designs for the statue must be approved by the legislature.

A rendering, created with artificial intelligence, of what the Charlie Kirk statue at New College of Florida could look like (yeah, Florida is considering the same thing)

Each plaza must also include “permanent signage commemorating Charlie Kirk’s courage and faith and explaining the significance of Charlie Kirk as a voice of a generation, modern civil rights leader, vocal Christian, martyr for truth and faith, and free speech advocate”.

I hope they make provisions for an adjacent vomitorium, because I’d need to use it.

The only truth is that proposed signage is that he was a vocal Christian. I think he was the perfect representative of the modern Christian. If only they could look into the mirror.

A very Chesley Bonestell future

Walt Disney and Werner von Braun teamed up to tell us how we were going to get to the moon…in 1955. There’s a certain familiar esthetic to the exercise — shiny, long pointy spaceships with fins, a huge multilevel rotating wheel a 50-man (literally, there are no women) space station, swarms of robotic-looking construction suits. They ditch the fins for their lunar vehicle, since you don’t need them in space…but they do keep the sleek pointy shape.

Every bit of it is wrong, in hindsight. I’m impressed with the elaborate models and the chiseled, handsome men who are floating about in the excessively roomy cabin, but von Braun’s vision of the future was all hype and glitz and was as ridiculous as anything Elon Musk proposes.

De novo genes in the news

I recently posted — and made a video about — a story about how de novo genes are made. I guess I was more timely than I expected, because The Scientist just posted on article on the same topic. It’s specifically about the work of Li Zhao, who is interested in the birth of new genes with novel functions, and is building on some other work done at UC Davis.

But around the same time Zhao began her research, new evidence challenged this longstanding view [that new genes don’t appear very often] with an alternative path. Population geneticist David Begun at the University of California, Davis (UC Davis) identified several de novo genes—genes originating from scratch, or non-coding DNA—in Drosophila melanogaster, the common fruit fly. Of the five genes, four occurred on the X chromosome and predominantly expressed in the testes, possibly under sexual selection pressures.

One other thing I should mention: my previous article focused on de novo genes in humans, who are terrible experimental subjects. Li Zhao is working on Drosophila, and there’s a reason flies are a premier model system for this kind of work — you can get multiple generations fast, you can do all kinds of genetic manipulations on them, and you can compare different lineages to evaluate the effects of the presence or absence of a specific gene. Or hundreds of genes, as she is finding.

By characterizing the transcriptomes of six previously sequenced D. melanogaster strains in the testes, Zhao and her colleagues uncovered potential de novo candidates. Of these, they identified 142 polymorphic (which segregated and evolved under selection) and 106 fixed (which remained consistent since the split from a common ancestor) de novo genes. Most of these candidates were regulated by cis elements, with expression driven by regulatory sequences just upstream of the new transcripts. The vast majority contained open reading frames (ORFs)—sections that could potentially produce proteins, marked by start and stop codons—of at least 150 base pairs. When comparing these sequences to ancestral genomes and non-expressing Drosophila strains, the same ORFs appeared, suggesting that the gene expression was driven primarily by regulatory changes.

Zhao and her colleagues proposed that these de novo genes may have undergone natural selection, as highly expressed genes were generally longer and more complex than those expressed at lower levels. However, whether these sequences were translated into proteins or served other functions remained unclear at the time. “Biology is more complex than what we imagine,” said Zhao.

Cool. But I’m going to don my skeptical hat, and suggest that I’m not seeing evidence that these novel genes are significant. The mechanisms for generating them are so easy that we shouldn’t be surprised that new genes are bubbling up out of the mostly chaotic junk in the genome, but when you don’t know what role those genes are playing in the organism, it’s a reach to suggest that they are important. I’m also unconvinced by observations of tissue-specific regulation during development — it’s also not difficult for regulatory sequences to be attached to a gene. Is it significant that so many of these novel genes are expressed in the testes? Male patters of gene expression in the gonads is a special case, and spurious expression could persist there because it has specific effects on sperm maturation that aren’t reflected in adult survival.

It’s still interesting stuff. I like the idea that entirely new genes trickle into populations and could contribute to variation in surprising ways.

Proving that free speech was never the goal

I guess we aren’t done with Charlie Kirk. The talk show host, Jimmy Kimmel, made a few entirely accurate remarks that were mainly critical of Trump and the Right’s efforts to capitalize on an assassination, and on Trump’s infantile mental ability.

On Tuesday’s “Jimmy Kimmel Live!” the host, during his monologue, addressed Charlie Kirk’s murder and the way some Republicans were seeking to portray the suspect, Tyler Robinson. “We hit some new lows over the weekend with the MAGA gang desperately trying to characterize this kid who murdered Charlie Kirk as anything other than one of them and doing everything they can to score political points from it,” Kimmel said, before pivoting to a segment where a reporter asked Trump how he was holding up, and he responded, in part, by bragging about White House construction.

“This is not how an adult grieves the murder of someone he called a friend,” Kimmel said. “This is how a 4-year-old mourns a goldfish.”

Kimmel also talked about Trump’s appearance on “Fox & Friends,” where Trump related the story about how he learned of Kirk’s death, and talked again about the construction.

“There’s something wrong with him,” Kimmel said. “There really is. Who thinks like that?”

For that, he has been yanked off the air indefinitely, maybe permanently. This is political censorship; his words were not particularly offensive to anyone, especially at a time when Trump is clearly losing his faculties, and when right-wing figures are declaring war on the Left.

So much for free speech. We knew that was never their honest goal.

Kirk was a parasite, notable for the fact that he used the illusion of civility to worm his way into the affections of pundits on both sides of the aisle, who praised the way he said things, rather than the content of his speech. He was an unabashed racist, anti-semite, misogynist, Christian nationalist, and queer-baiter, but we’re not allowed to say that now — in fact, quoting his own despicable words is a great way to get canceled.

They’re probably sharpening their knives for Ta-Nehisi Coates, who still speaks truth to power.

Before he was killed last week, Charlie Kirk left a helpful compendium of words—ones that would greatly aid those who sought to understand his legacy and import. It is somewhat difficult to match these words with the manner in which Kirk is presently being memorialized in mainstream discourse. New York Times columnist Ezra Klein dubbed Kirk “one of the era’s most effective practitioners of persuasion” and a man who “was practicing politics in exactly the right way.” California governor Gavin Newsom hailed Kirk’s “passion and commitment to debate,” advising us to continue Kirk’s work by engaging “with each other, across ideology, through spirited discourse.” Atlantic writer Sally Jenkins saluted Kirk, claiming he “argued with civility” and asserting that his death was “a significant loss for those who believe engagement can help bridge disagreements.”

The mentions of “debate” and “engagement” are references to Kirk’s campus tours, during which he visited various colleges to take on whoever come may. That this aspect of Kirk’s work would be so attractive to writers and politicians is understandable. There is, after all, a pervasive worry, among the political class, that college students, ensconced in their own bubbles, could use a bit of shock therapy from a man unconcerned with preferred pronouns, trigger warnings, and the humanity of Palestinians. But it also shows how the political class’s obsession with universities blinds it to everything else. And the everything-else of Kirk’s politics amounted to little more than a loathing of those whose mere existence provoked his ire.

It is not just, for instance, that Kirk held disagreeable views—that he was pro-life, that he believed in public executions, or that he rejected the separation of church and state. It’s that Kirk reveled in open bigotry. Indeed, claims of Kirk’s “civility” are tough to square with his penchant for demeaning members of the LGBTQ+ community as “freaks” and referring to trans people with the slur “tranny.” Faced with the prospect of a Kamala Harris presidency, Kirk told his audience that the threat had to be averted because Harris wanted to “kidnap your child via the trans agenda.” Garden-variety transphobia is sadly unremarkable. But Kirk was a master of folding seemingly discordant bigotries into each other, as when he defined “the American way of life” as marriage, home ownership, and child-rearing free of “the lesbian, gay, transgender garbage in their school,” adding that he did not want kids to “have to hear the Muslim call to prayer five times a day.” The American way of life was “Christendom,” Kirk claimed, and Islam—“the sword the left is using to slit the throat of America”—was antithetical to that. Large “dedicated” Islamic areas were “a threat to America,” Kirk asserted, and New York mayoral candidate Zohran Mamdani was a “Mohammedan,” with Kirk supposing that anyone trying to see “Mohammedism take over the West” would love to have New York—a “prior Anglo center”—“under Mohammedan rule.”

Kirk habitually railed against “Black crime,” claiming that “prowling Blacks go around for fun to go target white people.” He repeated the rape accusations against Yusef Salaam, a member of the exonerated Central Park Five who is now a New York City councilman, calling him a “disgusting pig” who had gotten away with “gang rape.” Whatever distaste Kirk held for Blacks was multiplied when he turned to those from Haiti. Haiti was, by Kirk’s lights, a country “infested with demonic voodoo,” whose migrants were “raping your women and hunting you down at night.” These Haitians, as well as undocumented immigrants from other countries, were “having a field day,” per Kirk, and “coming for your daughter next.” The only hope was Donald Trump, who had to prevail, lest Haitians “become your masters.”

The point of this so-called mastery was as familiar as it was conspiratorial—“great replacement.” There was an “anti-white agenda,” Kirk howled. One that sought to “make the country more like the Third World.” The southern border was “the dumping ground of the planet,” he claimed, and a magnet for “the rapists, the thugs, the murderers, fighting-age males.” “They’re coming from across the world, from China, from Russia, from Middle Eastern countries,” he said, “and they’re coming in and they’re coming in and they’re coming in and they’re coming in…”

You can probably imagine where this line of thinking eventually went.

“Jewish donors,” Kirk claimed, were “the number one funding mechanism of radical open-border, neoliberal, quasi-Marxist policies, cultural institutions, and nonprofits.” Indeed, “the philosophical foundation of anti-whiteness has been largely financed by Jewish donors in the country.”

Tommy Robinson, a far-right British activist, held a rally this week in which supporters chanted support for Kirk. The gathering turned violent, injuring 26 police officers.Lab Ky Mo/SOPA Images/LightRocket/Getty Images.

Kirk’s bigotry was not personal, but extended to the institution he founded, Turning Point USA. Crystal Clanton, the group’s former national field director, once texted a fellow Turning Point employee, “I HATE BLACK PEOPLE. Like fuck them all … I hate blacks. End of story.” One of the group’s advisers, Rip McIntosh, once published a newsletter featuring an essay from a pseudonymous writer that said Blacks had “become socially incompatible with other races” and that Black culture was an “un-fixable and crime-ridden mess.” In 2022, after three Black football players were killed at another college, Meg Miller, president of Turning Point’s chapter at the University of Missouri, joked (“joked”) in a social media message, “If they would have killed 4 more n-ggers we would have had the whole week off.”

Kirk subscribed to some of the most disreputable and harmful beliefs that this country has ever known. But it is still chilling to think that those beliefs would be silenced by a gunshot. The tragedy is personal—Kirk was robbed of his life, and his children and family will forever live with the knowledge that a visual record of that robbery is just an internet search away. And the tragedy is national. Political violence ends conversation and invites war; its rejection is paramount to a functioning democracy and a free society. “Political violence is a virus,” Klein noted. This assertion is true. It is also at odds with Kirk’s own words. It’s not that Kirk merely, as Klein put it, “defended the Second Amendment”—it’s that Kirk endorsed hurting people to advance his preferred policy outcomes.

In 2022, when Kirk was frustrated, for instance, by the presence of Lia Thomas on the University of Pennsylvania women’s swim team, Kirk did not call for “spirited discourse.” Instead, while discussing a recent championship tournament, he said he would have liked to have seen a group of fathers descend from the stands, forming “a line in front of [Lia] Thomas and saying, ‘Hey, tough guy, you want to get in the pool? ’Cause you’re gonna have to come through us.” Mere weeks before his death, Kirk reveled in Trump’s deployment of federal troops to DC. “Shock and awe. Force,” he wrote. “We’re taking our country back from these cockroaches.” And in 2023, Kirk told his audience that then president Joe Biden was a “corrupt tyrant” who should be “put in prison and/or given the death penalty for his crimes against America.”

What are we to make of a man who called for the execution of the American president, and then was executed himself? What are we to make of an NFL that, on one hand, encourages us to “End Racism,” and, on the other, urges us to commemorate an unreconstructed white supremacist? And what of the writers, the thinkers, and the pundits who cannot separate the great crime of Kirk’s death from the malignancy of his public life? Can they truly be so ignorant to the words of a man they have so rushed to memorialize? I don’t know. But the most telling detail in Klein’s column was that, for all his praise, there was not a single word in the piece from Kirk himself.

More than a century and a half ago, this country ignored the explicit words of men who sought to raise an empire of slavery. It subsequently transformed those men into gallant knights who sought only to preserve their beloved Camelot. There was a fatigue, in certain quarters, with Reconstruction—which is to say, multiracial democracy—and a desire for reunion, to make America great again. Thus, in the late 19th century and much of the 20th, this country’s most storied intellectuals transfigured hate-mongers into heroes and ignored their words—just as, right now, some are ignoring Kirk’s.

Words are not violence, nor are they powerless. Burying the truth of the Confederacy, rewriting its aims and ideas, and ignoring its animating words allowed for the terrorization of the Black population, the imposition of apartheid, and the destruction of democracy. The rewriting and the ignoring were done not just by Confederates, but also by putative allies for whom the reduction of Black people to serfdom was the unfortunate price of white unity. The import of this history has never been clearer than in this moment when the hard question must be asked: If you would look away from the words of Charlie Kirk, from what else would you look away?

Fuck Ezra Klein, fuck Gavin Newsom, and fuck ABC news. Also, damn these people who are going to speak at his memorial service, you know they aren’t going to bring up his unapologetic racism, except to praise it. Especially Stephen Miller.

Charlie Kirk’s widow, Erika Kirk
President Trump
Vice President JD Vance
White House Chief of Staff Susie Wiles
Secretary of State Marco Rubio
Health and Human Services Secretary Robert F. Kennedy Jr.
Secretary of Defense Pete Hegseth
Director of National Intelligence Tulsi Gabbard
Donald Trump Jr.
Tucker Carlson
Deputy Chief of Staff for Policy Stephen Miller
Ambassador to India nominee Sergio Gor

I can understand the widow speaking, but the rest are all there to promote hatred. Don’t expect an honest word out of any of them.

Must-see TV!

He always looks like such a buffoon, even with a stupid crown

Donald Trump is visiting England, why I don’t know. I hope all my friends in Great Britain are prepared to boo and hiss and shout rude things at him while he’s there. It seems some in the media are prepared to respond appropriately to him.

More than 100 of Donald Trump’s inaccurate statements are to be dissected by Channel 4 to coincide with his state visit, in what it described as “the longest uninterrupted reel of untruths, falsehoods and distortions ever broadcast on television”.

Give him hell. That’s what our media should be doing but isn’t.

Maybe we’ll get it on YouTube or something later?

Looking forward to going under the knife

I have arthroscopic surgery scheduled for the 26th of September. Hooray! I first went to this doctor in July, and he had hopes that I’d heal up with time — I guess that I was hobbling in on a cane and grimacing with every step told him that he’s going to have to poke holes in me and stitch something up.

Then he thinks I’ll need about two weeks of recovery time, unless they discover something horrible. I’ll try to be optimistic, but optimism isn’t working out so far.

When we got home from the clinic, there was another chrysalis just outside my door. Maybe that’s a promising sign?