How is an eyeball like an erection?

My next lecture in my neurobiology course is going to be about metabotropic receptors and how modulating internal cGMP levels is one way neuronal activity can be affected. I was planning to use the eye as an example of this process — but now Revere has inspired me to add a bit about the penis and viagra to the lecture. Here at UMM, we’re all about giving students information they can use.

How do you teach evolution?

I was just turned on to this recent issue of the McGill Journal of Education which has the theme of teaching evolution. It’s a must-read for science educators, with articles by UM’s own Randy Moore, Robert Pennock, Branch of the NCSE, and Eugenie Scott, and it’s all good. I have to call particular attention the article by Massimo Pigliucci, “The evolution-creation wars: why teaching more science just is not enough”, mainly because, as I was reading it, I was finding it a little freaky, like he’s been reading my mind, or maybe I’ve been subconsciously catching Pigliucci’s psychic emanations. I think I just need to tell everyone to do exactly what this guy says.

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Mutations in the CFTR gene cause Cystic Fibrosis

So one of the questions on our Neurobiology test due today was to see if there were any heritable diseases in humans that are caused by defects in ion channel genes. I discovered that mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene have been linked to Cystic Fibrosis (CF).

CF is a genetic disease that affects the lungs and digestive system of its victims. The defective CFTR gene produces a thick, sticky mucus that provides an environment for life-threatening pathogens to establish an infection, and can clog the lungs. This unusually thick mucus also interferes with the pancreas, and impairs the enzymes that help to break down food and allow the body to absorb it. The symptoms of CF include frequent lung infections; persistent coughing, oftentimes accompanied by phlegm; wheezing or shortness of breath; poor growth or weight gain, despite a healthy diet and appetite; salty tasting skin; and difficulty in bowel movements or greasy, bulky stools. The incidence is about one thousand new cases a year.

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The October Molly should go to…

With so many delightful and extensive conversation examples lately, this must be the perfect opportunity to mention that it is time to select the new Molly winner for October! Leave a comment here naming names of the people you like to read in the comments, and I’ll tally them up at the end of the weekend.

Since there is a wee bit of acrimony going on right now, I’ll remind everyone that this is to be a positive process — no howling against any nominee. If you think someone mentioned is just awful, please instead of trying to cast negative votes (I don’t count them), get behind someone you do like.

Invitingly halloweeny

Now this is the kind of thing I’d like to have on my lawn…

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…except, unfortunately, that I have to miss Halloween this year. Halloween is a Ray Bradbury-esque holiday best celebrated in the midwest, and I’m going to be spending that day in the sunny, cheery, less-than-autumnal climes of Southern California, dispelling ghosties, I hope.

No purposes but those we create for ourselves

Those sneaky rascals at the Templeton Foundation have asked one of those ridiculous questions that gets some otherwise rational people stumbling over themselves to give an inoffensive answer: does the universe have a purpose? Of course, the irrational people have no trouble piping up with a happy “Yes!”, which should clue everyone in, as Larry notes, that it’s a gimmick question designed to provoke a range of waffly answers … and waffles, especially the tepid, limp kind, are the stock-in-trade of the Templeton House of Waffles.

I’d say “no, there is no evidence of universal purpose and no reason to assume one,” and be done with it. Except, perhaps, to ask those who say “yes” to specify exactly what that purpose is, and how they know it.

Near as I can tell, the primary purposes of the universe as discerned from the casual expressions of religion’s proponents are 1) to bias victory in local football games, and 2) to regulate the appropriate orifices into which certain people are allowed to place their penises. How the creation of Betelgeuse, the concentration of planetary material in our solar system in one body which we can’t reach and which is uninhabitable to us, and the ubiquity and success of bacteria all play into these purposes is unknown to me … it must be one of God’s mysteries.

Return Ben Stein’s Money

I’m a bit disappointed with Al Franken. Ben Stein has donated to the Franken campaign, and he has accepted the money — come on, Al, let’s see some principles. Stein is a dishonest fraud who is peddling Intelligent Design creationism in his upcoming movie, Expelled; he’s a former Nixon speechwriter, and he defends Nixon. I know they might be friends in their personal life, but this is politics — Franken should stand up for his liberal ideas and courteously refuse to take money from a stupid right-winger.

Besides supporting pseudoscience in the schools, here’s another reason to reject Stein. There’s a letter that’s been going around for some time, purportedly from Ben Stein. According to Snopes, only part of it is, so I’ll just tackle the part that we can assign to Stein’s feeble brain.

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It’s always much more complicated than you think

I mentioned before Cosma Shalizi’s excellent discussion of heritability; add to that now his summary of g. We’ve got a few pompous no-nothings lurking in the comments who are fond of declaiming that they know that they have proof that the brain works in such-and-such a way, and that we can blithely assert an average stupidity exists in broad swathes of humanity (said broad swathes typically sweep across very diverse groups, united only by the obvious ephemera of skin color), but they need to read and comprehend those articles in order to learn that their certainty of a heritable simplicity is a phantasm.

Reality says that race is a category error, and that IQ foolishly tries to pin complexity into a cramped and tiny corner, and that human minds are both diverse and similar … and the great gross simplifications of racists, scientific and otherwise, are lies to comfort fearful bigots.

Cosma has another post that summarizes the exasperation we should all feel.