Darwin had difficult handwriting

Find out for yourself. Darwin Online has acquired a huge digital collection of Darwin’s papers, everything from book drafts to personal letters, and has them scanned and available on the web. There they are in all their scribbled, crossed out, penciled over, rewritten glory — historians and antiquarians will drool over these, but me, I prefer the neatly typed versions.

The collection of family photos is pretty darned cool, though.

The sleaze is growing

This is just getting weirder and weirder. What kind of dummies are behind Expelled, anyway? First they lied about the premise of their movie to get interviews; then they copied Harvard/XVIVO’s cell animations; then they threatened XVIVO with a lawsuit; now it turns out that they’re using music from John Lennon and The Killers without permission, stirring the ire of Yoko Ono. It’s total legal chaos, as far as I’m concerned, and I’m not going to even guess how any of it will turn out. Is the movie industry always this rife with sneakiness and dishonesty?

Anyway, no matter how the lawyers dance, one thing is clear: the makers of Expelled have been paragons of ethical dubiety, doing their best to skirt the edges of the law and sneak as much doubtful, dishonestly obtained content into their little propaganda movie as they can. I guess they had to skimp on the budget for the actual content of the movie to scrape together a very large advertising budget — it’s as if their movie is a metaphor for all of Intelligent Design creationism.

God must really hate black people

A family of Minnesotans were involved in a horrific plane crash in the Congo.

Barry and Marybeth Mosier were on their way to visit their son Keith, 24, in Kinsangani, Congo, with two younger children when their plane crashed on takeoff Tuesday in Goma. At least 36 people died as the plane plowed through a market and burned. Most of the people who died were on the ground, according to the U.N. mission in DR Congo.

…Mosier said, he and his wife were carrying their son Andrew, 3, in the shoving “mass of humanity” trying to escape the burning plane. They got out through the opening in the fuselage.

“Outside the plane, she was wandering around. … It was total chaos,” he said. “People were screaming and yelling because the plane had landed on this market. All of a sudden, out of the blue, all of these people who were just standing there are now dead.

“So there’s parts of bodies and people burning and people screaming and yelling, and she was out there by herself.”

It sounds like a nightmarish event, and I’m glad they survived. I wish a few more people hadn’t died horrible, painful deaths in such a catastrophe, but this was a family of despicable missionaries, so you know what’s coming next.

“We couldn’t believe that our family of four could all escape a plane that was crashed and on fire, but by God’s mercy, we did,” he said.

Mosier said he believes the family made it for a reason.

“I think the Lord has a plan for us, otherwise we wouldn’t have survived,” he said. “He still has work for us to do.”

Their god has no mercy to spare for the innocent people in the market, of course, and their lives must have been totally useless for their god to be able to dispense with them in such a brutal fashion. Or perhaps they were wicked and deserved a flaming extinction with lots of fear and screaming?

In a just theistic world, I think their god would despise such smug, self-satisfied Christians.

Who needs a vat when you’ve got a chicken?

Revere is thinking about how to grow meat without the animal. It’s a cool idea that’s been floating around in science fiction for a while now, but, well, of course it has problems, and Revere notes a couple.

The two biggest, as far as I can see from a quick perusal of the burgeoning literature, are finding a suitable nutrient to grow the cells in; and then growing tissue that has the proper texture for being a meat substitute. Animal meat is not just muscle cells but a complicated structure also containing connective tissue, blood and blood vessels, nerves and fat. Just growing up masses of identical cells isn’t sufficient. You have to reproduce an architecture.

I see those two problems as aspects of one much bigger problem. Muscle doesn’t grow in isolation: it’s always in a solid environmental context. It’s made up of cells that respond to activity in a way that enhances performance for the organism, and incidentally promotes flavor and texture and bulk for the delectation of the carnivore. So what do you need to make edible muscle mass, beyond a sheet of myocytes in a culture dish (which, I suspect, would have the texture of slime and would not sell well in test markets)?

An architecture is right. You need connective tissue to form a framework and you need a rigid but motile structure to do work and exercise the growing muscle. Then, because you want a piece of muscle larger than a drop, you need a delivery system for nutrients: a circulatory system, with a pump. This muscle in a vat is going to need a skeleton and a heart.

When I teach physiology, one of the organs I emphasize is the liver. It’s amazing how important a liver is to just about everything: growth, digestion, physical performance, reproduction, the whole shebang. Our cultured muscle will need a liver equivalent to support it. Even if we get rid of the digestive system entirely and feed this muscle mass on delivered supplies of pure glucose, amino acids, and various cofactors and enzymes, the liver is a primary regulatory agent for those substances.

Then we need an immune system. A huge lump of cells growing in a bath of sugar and amino acids is bacterial heaven — it’s going to need major antibacterial/antiviral support.

The more I think about it, the more I think people are going at it backwards. We shouldn’t be thinking about building muscle from the cells up, to create a purified system to produce meat for the market, we should be going the other way, starting with self-sustaining meat producers and genetically paring away the less commercially viable bits, like the brain. Instead of test-tube meat, we should be working on more efficient organisms that generate muscle tissue with the properties we want.

Guess what? Farmers have already been doing this! Look at the domestic cow and chicken and turkey: they’re far more brainless than their wild relatives, and have been reduced to as much stupidity and helplessness as possible, without compromising their ability to survive semi-autonomously and harvest nutrients from naturally occurring food sources. I don’t see all that much difference in the consequences between building up a functional meat producer from cells in a dish, and stripping down a functional meat producer from a line of domesticated animals. Both starting points are aiming at the same final result; I suspect that the top down procedure is more likely to achieve success in my lifetime.

I ♥ Philadelphia

Look what they’ve done: Philadelphia declares a whole Year of Evolution, a celebration starting on 19 April.

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The YEAR OF EVOLUTION kicks off for the public on Saturday, April 19, as the University of Pennsylvania Museum of Archaeology and Anthropology opens Surviving: The Body of Evidence, a new exhibition which explores the process of evolution and its outcomes. Other public programs so far scheduled at the University of Pennsylvania include lectures by Donald Johanson, Director, Institute for Human Origins (May 2008), Spencer Wells, Project Director of the National Geographic Genographic Project (October 2008), Charles Darwin expert E. Janet Browne, author of the two-volume Charles Darwin: Voyaging and the Power of Place (November 2008), and renowned biologist Ken Miller (February 2009). Additional lectures, Penn Museum programs for children and families, scholarly symposia, and an evolution-focused freshman class book-reading selection, will round out the University’s rich offerings.

The Academy of Natural Sciences, The Franklin, the Philadelphia Zoo, the Mütter Museum and College of Physicians, and the American Philosophical Society Museum join with Penn Museum and the University, in offering programming in the coming year. Included in the public offerings are exhibitions about the work of geneticist Gregor Mendel (Academy of Natural Sciences), and Charles Darwin (American Philosophical Society Museum), as well as an evolutionary perspective on a medical collection (Mütter Museum). Related IMAX movie programs at The Franklin, and a closer look at our closest relatives–fellow primates–at the Philadelphia Zoo, are all part of the year.

Dr. Howard Goldfine, Professor of Microbiology, School of Medicine, and Dr. Michael Weisberg, Assistant Professor of Philosophy, School of Arts and Sciences, are co-chairs of the University’s YEAR OF EVOLUTION. Dr. Janet Monge, Acting Curator of Physical Anthropology, Penn Museum, and co-curator of the Surviving exhibition, was instrumental in organizing the city-wide effort.

This is how it is done, people! Organize a whole series of positive, informative events for your town, right now — you’ve fallen behind Philly!

Now I just need an excuse to visit…Philadelphia is a great old town that has just gotten better.

Things to do with your weekend

Plan ahead! It’s going to be a fun weekend!

This Thursday, 17 April, get a head start on the weekend with Virtually Speaking on Second Life. I’m being interviewed at 6pm Pacific Time, and this could be spectacularly entertaining: I’m a total newbie at SL, so I’m going to be getting lessons in how to sit down this afternoon, which tells you that there will be opportunities for major klutzy gaffes at this event. I’m afraid I might turn into a giant flying penis sometime mid-interview.

Friday evening at 7:30 pm, we have the UMM Dance Ensemble performance in Edson Auditorium here on campus. Some of my students are performing, so come on by and support interdisciplinary, liberal arts education by cheering on dancing biologists!

There is a major movie premiere this weekend: Zombie Strippers, starring the renowned thespian, Jenna Jameson. Unfortunately, it’s not playing in Morris, and it does look like the very best movie opening this weekend, so I’m afraid this is probably the weekend to skip going to the theaters.

With one special exception! The Morris Theatre, in a special showing, has engaged a one-time 3:00 Saturday matinee showing of the horror classic, Theatre of Blood, starring Vincent Price and Diana Rigg. Come on, people! Classic 70s horror with a master of the genre shown in an actual old-time single screen movie theater? How can you miss this? There’s also going to be a post-movie discussion of Shakespearian themes in the film afterwards, at the Common Cup Coffeehouse. I’m going to be there — it’ll warm me up for the next event of the evening.

At 8:00 Saturday, in the Science Auditorium on campus, I’m debating Angus Menuge on “Does neuroscience leave room for God”. It may be a bit of a let down after Theatre of Blood — there will probably be no beheadings, sword fights, or eviscerations — but we could have a feisty argument.

I know, Morris is a long ways from everything, but it’s going to be the happening place on the whole planet for a few days. If anyone feels like making the long trip out, send me email, and I can give you directions.

Fortunately, there is no building in Morris tall enough to need an elevator

Well, except for the grain silos, that is, but I don’t need to go in those. New York is a whole different story, though. This story about elevators is informative, because it tells you all about the construction and safety features, takes a tour of the Otis company, and even talks about the psychology of spacing oneself in a crowded elevator…but the part that will stick with you is the saga of poor Nicholas White, who was forgotten in a stuck elevator for 41 hours over one weekend — trapped in a small box for almost two days with absolutely nothing to do. I think I’d go insane.

Almost as painful: he was observed on time-lapse security cameras. Now you too can watch a man suffer extreme boredom and frustration. If this were a psychology experiment, it would never get past the review board, that’s for sure.

(via Kottke)