Those rocks belong to everyone

If you’ve ever been to a national park (or to most state parks), there are strict restrictions on what you are allowed to do as a visitor: you can’t back a pickup truck in and load it up with petrified wood, or an assortment of cactuses, or harvest a crop of squirrels. There are all kinds of rules to protect the status of the park from predatory hordes of visitors — if you go rafting through the Grand Canyon, for instance, get used to pooping into a can because you have to haul out everything you bring in.

This is true for everyone. You don’t get to say “Back off, man, I’m a scientist” to excuse going at the Grand Canyon walls with a rock hammer. You have to get a scientific collecting permit, and it’s no rubber stamp process — your application actually gets reviewed by qualified peers.

You know what’s even less effective? Saying Back off, man, I’m a creation scientist.

Creationists regularly run tours through the Grand Canyon, pointing at the rocks and misinterpreting them and using the lens of the Bible to lie about the science, and that’s OK. They’re hurting themselves with ignorance, but as long as they don’t wreck the experience for others, that should be their right. But Andrew Snelling, the Answers in Genesis geology wackaloon who thinks the canyon is only about 4,000 years old, wants to chip away at the rocks and haul away samples, which he will abuse to support his pet thesis. The National Park Service turned him down.

The NPS is awesome.

One of the many things that bug me about creationists is their dishonesty. Snelling had applied for a collecting permit, but avoided saying anything about what he intended to do and minimized his affiliations, pretty much the opposite of what real scientists do.

After conducting three other research projects in the Grand Canyon and guiding 30 river tours of the canyon, he filed a research proposal in Nov. 2013 seeking to collect 60 half-pound rock samples, the suit states. The 24-page proposal only once mentioned his role at Answers in Genesis and contained no other references to religious motivation or creationism.

Snelling claims park officials asked Snelling for two peer reviews evaluating his research proposal, something that hadn’t been asked for in his previous projects. He provided three, which court documents show were written by other academics who have participated in creationist research.

He was turned down. The reviews of his proposal are amusing.

Karl Karlstrom, Ph.D. with the University of New Mexico said Snelling proposal, in part, was not “well written, up-to-date or well referenced” and “I suspect his research application… is motivated by his faith that the Cambrian strata were deposited during Noah’s flood, which is the creationist (and certainly not the scientific) explanation for Grand Canyon strata.”

Peter Huntoon, a former professor at the University of Wyoming, said the park should adhere to “your narrowly defined institution mandate…that ours is a secular society as per our constitution” and argued creationists have already decided the answers to their proposed questions.

“Your internal screening processes should include an examination of the credentials of the submitters so that those who represent inappropriate interests should be screened out,” Hutton wrote and suggested a history of creationist research pre-dating Answers in Genesis.

The third peer-review from Ron Blakley of Northern Arizona University simply said, “it is difficult to review such an outlandish proposal.”

Huntoon’s remark is particularly apropos. Snelling has determined what the “answer” will be (it’s in Genesis!), and there is literally no purpose at all to collecting physical evidence that will be ignored in favor of a collection of ancient myths. That isn’t science.

So of course Answers in Genesis is suing the NPS, and is invoking the Holy Name of Donald Trump to do so.

The suit cites President Donald Trump’s executive order signed May 4 which states all executive departments and agencies shall, to the greatest extent practicable and to the extent of permitted law, respect and protect the freedom of persons and organizations to engage in religious and political speech.

In a press release, Ken Ham, president of Answers in Genesis said this will be a test case of Trump’s order.

Since when is breaking up bits of a park “free speech“?

Hey. I’ve got a rock hammer. I’m also going to visit the Answers in Genesis Ark Park next month. Donald Trump says I get to collect a few bits and pieces in the name of my inviolable religious rights. Do you think that will fly?

Scott Adams embarks on the Johnny Hart road

I don’t normally read Dilbert — I’ve seen far too much of the benighted ignorant psyche of its creator — but this one was just laid out on a table at the coffee shop yesterday, and I knew I’d have to deal with it. In this one, Dilbert goes full climate science denialist. This might be fun, to dissect Dilbert, because even though it will kill what little humor is present in it, at least we’ll have a good time laughing at Scott Adams. Let’s dissect the shit out of this thing.

Here’s the setup.

OK, this is sort of fine. I think it’s a good idea for companies to think about what impact climate change will have on them, and how they affect the environment. I’m at a green university, and we’ve had these sorts of discussions. Still do, all the time.

It is definitely true that human activity is warming the Earth. It will lead to a global catastrophe, depending on how you define catastrophe: it will cause acute economic disruption, resource wars, and the death of millions. Is that catastrophic enough for you?

By the way, I notice that the scientist is a goateed and balding white man in a lab coat. It’s either unconscious bias (that’s how scientists are supposed to look!), or, I can’t help but notice a weak resemblance to Michael Mann.

Next panel, Dilbert asks Scott Adams’ idea of a smart question.

On the face of it, yes, that is a good question. I’d encourage students to ask that every time an instructor told them something. But consider the context. The answer to that question is readily available — google it. You can read the papers. You should have the answer to that from your high school earth science class. So why is Dilbert being made to ask this trivial question right at the start of this meeting? I can tell right away that this is not a sincere question, this is a derailing tactic to justify a software engineer speaking out of his ass to the scientific expert. Sound familiar?

Then we get the eternal dilemma of the science popularizer. Do you just scorch this ass with contempt because you can see right through him, or do you try to take the question seriously and give the primer in kindergarten climatology he’s asking for?

You can’t win, you know. The game is rigged. If you do the former, you’ll be accused of being hostile and mean. If you do the latter, you’re patronizing and people will write scornful blog posts about how you think raw data dumps will cure all the scientific misunderstandings in the world.

So what do you do? Most of us will take the generous view and try to explain exactly what the questioner is asking for, like our Michael Mann surrogate here:

And that’s also fine. So far, the strip has been true to the characters, and the nature of their interactions. It’s denialist vs. scientist, familiar territory, and now it’s time for the funny, clever twist…but Adams can’t deliver. He has to resort to sticking words in the mouth of the scientist that are not at all true to the character.

That’s just wrong. It’s not what climate scientists say or even think. It’s what Scott Adams, who is no scientist of any kind, says and thinks. And with that betrayal of the premise of the joke, it abruptly falls flat and dies. If all you can do to discredit a point of view is to lie and make puppets say falsehoods, it’s your position that fails. Adams does this because he lacks any insightful response to the honest arguments of scientists.

I guess there’s supposed to be a punchline of some sort next. Once again, Adams fails to meet the minimal standards of his medium.

I think the punchline is supposed to be implying that science supporters can only defend their position by calling True Skeptics mean names. Of course, the entire point of the two panels just above that is to call climate scientists conscious liars.

The only people who will find this at all funny are the denialists who see the panels in which the climate scientist openly maligns his methodology as affirmations of their beliefs. That’s OK, it’ll finally be the death of Dilbert — I skimmed the comments and noticed several people were shocked that Scott Adams endorse an anti-scientific claim. Apparently they’ve never read his blog before.

I shouldn’t claim it’ll kill Dilbert, though. Nothing kills syndicated comics. Johnny Hart went full-blown creationist/evangelical Christian/anti-Muslim bigot, and newspapers just kept right on buying up the strips. Hart died in 2007, and B.C. is still going.

And people think tenured professors have it easy.

Creationists need better evidence than that

I found this claim by Mark Armitage that had determined that a triceratops fossil was only a few thousand years old to be ridiculous. He has a defender, Jay Wile, who disagrees with me. He has two main points.

First, I said that carbon dating a dinosaur fossil is absurd — the 14C levels will be too low to get a reliable ratio. Wile thinks that you can, and that being able to cite a number makes it true.

Well, had Dr. Myers bothered to click on the link given in my post, he would have seen that an age was reported: 41,010 ± 220 years. As I state in that link, this is well within the accepted range of carbon-14 dating, and it is younger than many other carbon-14 dates published in the literature. In addition, the process used to make the sample ready for dating has been spelled out in the peer-reviewed literature, and it is designed to free the sample of all contamination except for carbon that comes from the original fossil. Now as I said in my original post, it’s possible that the reading comes from contamination. However, I find that unlikely, given the process used on the sample, the cellular evidence that Armitage found, and the fact that such carbon-14 dates are common in all manner of fossils that are supposedly millions of years old or older.

There are two sources of 14C we have to be concerned with. The bulk of it is cosmogenic, formed in the upper atmosphere from cosmic ray bombardments of ordinary, stable 14N. This 14C decays at a geologically rapid rate, with a half-life of 5730 years. Living things respire and tend to equilibrate their 14C levels with the environment. Another source, though, is the radioactive decay of other elements that generate high energy particles that can also bang into atoms to generate unstable radioactive isotopes. This is a much rarer event, though, so objects that are dead and buried and isolated from the atmosphere tend to equilibrate to a much lower concentration of 14C.

In carbon dating, the 14C to 12C ratio is measured. If it’s close to that of the atmosphere, it was recently exchanging carbon with the atmosphere. If it’s somewhere above the level of dead carbon buried deep in rocks (which has a non-zero level of 14C), it’s older, and we can estimate how much older from the ratio. You can always calculate a ratio. You can always measure a date. However, it will hit a ceiling of about 50,000 years, because of the limits of precision and because the ratio can converge to a value indistinguishable from the background level of 14C. Date a carbon sample that’s a hundred thousand years old; it will return an age of 50,000 years. Carbon date a chunk of coal from the Carboniferous, 300 million years ago, and it will return an age of 50,000 years.

That an “age” was reported is meaningless. An age of 40,000 years means that about 7 14C half-lives had passed, or that less than 1% of the atmospheric levels of 14C were present in the sample. Wile doesn’t understand this at all. He doesn’t seem to comprehend that there could be another source of 14C than from equilibration with the atmosphere. He thinks it is significant that ancient carbon can have non-zero amounts of 14C.

However, creation scientists have carbon-dated fossils, diamonds, and coal that are all supposed to be millions of years old. Nevertheless, they all have detectable amounts of carbon-14 in them. For example, this study shows detectable levels of carbon-14 in a range of carbon-containing materials that are supposedly 1-500 million years old. Surprisingly, the study includes diamonds from several different locations! Another study showed that fossil ammonites and wood from a lower Cretaceous formation, which is supposed to be 112-120 million years old, also have detectable levels of carbon-14 in them. If these studies are accurate, they show that there is something wrong with the old-earth view: Either carbon dating is not the reliable tool it is thought to be for “recent” dating, or the fossils and materials that are supposed to be millions of years old are not really that old. Of course, both options could also be true.

Or that there are underground sources of radioactive decay that can generate low levels of 14C, and that Jay Wile doesn’t understand basic principles of radiometric dating.

Wile also dismisses the possibility of an inclusion of recent biological material in the sample that might skew the date earlier, which is unjustifiable. Armitage himself writes about Soft, moist, muddy material can be seen surrounding pores of bone vessels on inner horn surfaces and rootlets penetrating lower, interior surface of samples where he claims to spot intact Triceratops cells.

But contamination can’t possibly be a confounding problem, oh no.

The second main point Wile makes is that gosh, those cells sure look like osteocytes, which have a distinctive shape with many branching processes. How would osteocytes have gotten in there?

Armitage did not compromise his own results. He simply wrote truthfully about his fossil. In addition, anyone with a basic understanding of histology would know why plant roots, fungal hyphae, and insect remains do not compromise his results in any way. Based on all the visual evidence, the cells he found are osteocytes. They are not only the shape and size one expects from osteocytes, they have the filipodial extensions that are characteristic of osteocytes. They also have the cell-to-cell junctions one expects in groups of osteocytes. Thus, they cannot be the result of contamination, since plants, fungi, and insects do not have osteocytes.

My answer to that is…I don’t know. It’s weird. And Armitage doesn’t know either, and everything he says about the sample is incompatible with these being intact, preserved osteocytes.

The fact that any soft tissues were present in this heavily fossilized horn specimen would suggest a selective fossilization process, or a sequestration of certain deep tissues as a result of the deep mineralization of the outer dinosaur bone as described by Schweitzer et al. (2007b). As described previously, however, the horn was not desiccated when recovered and actually had a muddy matrix deeply embedded within it, which became evident when the horn fractured. Additionally, in the selected pieces of this horn that were processed, soft tissues seemed to be restricted to narrow slivers or voids within the highly vascular bone, but further work is needed to fully characterize those portions of the horn that contained soft material. It is unclear why these narrow areas resisted permineralization and retained a soft and pliable nature. Nevertheless it is apparent that certain areas of the horn were only lightly impacted by the degradation that accompanied infiltration by matrix and microbial activity. If these elastic sheets of reddish brown soft tissues are biofilm remains, there is still no good explanation of how microorganisms could have replicated the fine structure of osteocyte filipodia and their internal microstructures resembling cellular organelles. Filipodial processes show no evidence of crystallization as do the fractured vessels and some filipodial processes taper elegantly to 500 nm widths.

So…

  • The tissue is not isolated or protected in any way. It’s wet, unmineralized, and filled with a “muddy matrix”. Some of the soft tissues, the “vessels”, are crystallized.

  • The “osteocytes”, though, are perfectly preserved down to the level of organelles, ultrastructural junctions, and delicate processes.

Doesn’t anyone else have a problem with this? I’ve had to struggle with fixative cocktails to get good preservation of single-cell levels of detail; I’ve had animal tissue bathed in a soothing, perfectly balanced medium under my microscope, and seen bacterial infections turn them into disintegrating, collapsing blobs of blebbed out fragments of decaying cells within minutes.

Yet somehow Armitage finds picture-perfect “osteocytes” in tissues that have been soaking in mud, perforated by plant roots, and presumably have been lying there rotting since, by his measure, some time around the Great Flood, a few thousand years ago.

I’m just curious. As an experiment, if we killed a cow and then left it to rot in a damp field for just a month, would that be a good way to make useful histological samples of bone tissue?

How about if we left it there for a year? Or 40,000 years?

The Schweitzer papers on preserved cells in dinosaur bone at least demonstrate careful technique to minimize contamination and artifacts. They also don’t include comments that reveal the author doesn’t understand the basic principles of radiometric dating. The Armitage papers, on the other hand, are sloppy, get improbable results, and reveal a lot of biased reasoning.

I don’t know how cells that look like osteocytes got there, but I’m very suspicious.

Life is too easy for comic artists

They don’t even have to write their own jokes any more!

Doonesbury: Well, I want to just start by saying hopefully they’re going to have to fear nothing, ultimately. Right now there is a fear and there are problems, certainly problems, but ultimately I hope there won’t be a fear and won’t be problems and the world can get along. That would be the ideal situation. It’s crazy what’s going on, whether it’s the Middle East or you look at no matter where, the Ukraine, you look at — whatever you look at, it’s got problems. So many problems. And ultimately, I believe that we are going to get rid of most of those problems and there won’t be fear of anybody. That’s the way it should be.

Those word balloons contain obvious bullshit from a bullshit artist — they sound exactly how a kid who hasn’t done their homework sounds when called on in class. It’s ridiculous. It’s meaningless noise. It’s not even good or entertaining bullshit.

But there’s that little note in the third panel: “verbatim from press conf., 4/12/17”. I know, it’s Trump, so of course it’s possible that such crap dribbled out of his mouth, but I had to check. Here’s a partial transcript of his answer, and if that’s not good enough, there’s video of the press conference — skip ahead to about 25:50 to hear the reporter’s question and his ludicrously stupid reply.

I think Garry Trudeau would agree that his ease and comfort in generating text for his cartoons is not adequate compensation for having to live with that boob in charge of the government.

Davies and Lineweaver are back on the atavisms bandwagon

I’ve been complaining about the cancer nonsense peddled by Paul Davies and Charles Lineweaver for years. I imagine nothing will stop them. They’ve got this weird idea that cancers are atavisms — that what they are is a reactivation of an ancestral program that was constructed a billion years ago by free-living single-celled organisms, that was then shackled and constrained by the evolution of multicellularity, but which can then re-emerge when the old program is liberated by mutations in the multicellularity genes that are its jailers. Cancers are your protistan ancestors, yearning to break free.

It’s nonsense. Davies and Lineweaver are physicists with no comprehension of how evolution works. There are no ‘genetic programs’ that can linger for a billion years in a suppressed state to functionally rebound with the accidental removal of a metazoan control program. When you add that Davies justifies his model by invoking Haeckelian recapitulation, a theory that’s been dead and wrong for over a century, you’ve got a recipe for raging crackpotterism from a sober, respected physicist.

Yet they still get published. They still manage to sucker in scientists who ought to know better. They’ve published again in PLoSOne, in a paper titled “Ancient genes establish stress-induced mutation as a hallmark of cancer”. Here’s the abstract.

Cancer is sometimes depicted as a reversion to single cell behavior in cells adapted to live in a multicellular assembly. If this is the case, one would expect that mutation in cancer disrupts functional mechanisms that suppress cell-level traits detrimental to multicellularity. Such mechanisms should have evolved with or after the emergence of multicellularity. This leads to two related, but distinct hypotheses: 1) Somatic mutations in cancer will occur in genes that are younger than the emergence of multicellularity (1000 million years [MY]); and 2) genes that are frequently mutated in cancer and whose mutations are functionally important for the emergence of the cancer phenotype evolved within the past 1000 million years, and thus would exhibit an age distribution that is skewed to younger genes. In order to investigate these hypotheses we estimated the evolutionary ages of all human genes and then studied the probability of mutation and their biological function in relation to their age and genomic location for both normal germline and cancer contexts. We observed that under a model of uniform random mutation across the genome, controlled for gene size, genes less than 500 MY were more frequently mutated in both cases. Paradoxically, causal genes, defined in the COSMIC Cancer Gene Census, were depleted in this age group. When we used functional enrichment analysis to explain this unexpected result we discovered that COSMIC genes with recessive disease phenotypes were enriched for DNA repair and cell cycle control. The non-mutated genes in these pathways are orthologous to those underlying stress-induced mutation in bacteria, which results in the clustering of single nucleotide variations. COSMIC genes were less common in regions where the probability of observing mutational clusters is high, although they are approximately 2-fold more likely to harbor mutational clusters compared to other human genes. Our results suggest this ancient mutational response to stress that evolved among prokaryotes was co-opted to maintain diversity in the germline and immune system, while the original phenotype is restored in cancer. Reversion to a stress-induced mutational response is a hallmark of cancer that allows for effectively searching “protected” genome space where genes causally implicated in cancer are located and underlies the high adaptive potential and concomitant therapeutic resistance that is characteristic of cancer.

A translation:

  • Some have said that cancer is a reversion to the single-celled state. The “some” just happens to be us.

  • We naively predict that the genes involved in a disease of multicellularity, cancer, would be genes that have evolved after the emergence of multicellularity. We helpfully defined a colossal window of one billion years to assay.

  • We compared the distribution of cancer-causing mutations to a uniform, random distribution of mutations. Surprise: some mutations cause cancer, others don’t, so it doesn’t fit a random distribution. There are lots of genes that are less than 500 million years old that are implicated in cancer.

  • But wait! When we looked in a database of cancer-causing gene mutations, COSMIC, we find that the database is enriched for old genes. This is contrary to our hypothesis, therefore we need to find a new rationalization, rather than rejecting our hypothesis.

  • The genes that are commonly broken in cancer are involved in DNA repair and cell cycle control, which are truly primitive, ancient functions — prokaryotes have genes for this. What possible “ancient program” could be reactivated to fit our story?

  • I know! Stress-induced hypermutation! Cancer cells are invoking multi-billion year old processes; it can’t be that breaking genes produces a loss of specificity and efficiency in repair, they are switching on genes to cause mutations. They’re doing it on purpose! Yeah, that’s the ticket!

It’s a truly awful mess of a paper, in which the authors juggle lots of data to make it fit their preconceptions, and in which apparently no result can possibly cause them to reject their hypothesis. And their conclusions are strange.

Here we present evidence demonstrating that cancer manifests as an atavistic recapitulation of pre-metazoan mechanisms of stress-induced mutation in somatic cells, explaining its capacity to evolve resistance to therapy. The mechanistic roots of this behavior are retained over evolutionary time scales because they are critical to the successful function of the germline and immune system. In addition to generating base-line diversity in both the innate and adaptive immune system, normal germline mutational patterns maintain diversity in recently evolved gene families governing functions such as toxin detection and detoxification. In cancer the controlled restriction of this phenomenon to the germline and immune system is disrupted, allowing somatic cells to effectively search ancient genome space for solutions to the stress-induced pressures they are experiencing. We propose stressed-induced mutation as a hallmark of cancer reflected by genomic instability.

There is a phenomenon in the immune system where, for instance, the immunoglobulin genes are prone to greater mutation rates during cell proliferation — it is a way to increase the diversity of antibody types. So yes, there are mechanisms to increase the rate of errors. What Davies and Lineweaver are proposing is that cancer cells are actively and purposefully switching on these mutation-generating processes to “search ancient genome space”, whatever the hell that is and however the hell inducing a greater frequency of random mutations would find and restore these imaginary “ancient genes”. Note also that they’re babbling about “atavistic recapitulation of pre-metazoan mechanisms” while discussing properties of the adaptive immune system. This makes no sense.

Genomic instability is one of the hallmarks of cancer. It’s not necessarily a planned sort of thing. If you disrupt DNA repair mechanisms with a mutation, you’ll get more mutations in other genes. If you mutate the gatekeeping proteins that act to ensure that cell division does not proceed if you have gross chromosomal errors, you will have more gross chromosomal errors. The fact that populations of cancer cells routinely accumulate new mutations as they progress is not an observation that supports the idea that cancers are a reversion to an ancestral healthy, single-celled state.

If you need to cleanse your palate after that dog’s breakfast of bad science, here’s a much more interesting paper on cancer: Carbon dating cancer: defining the chronology of metastatic progression in colorectal cancer. The investigators took advantage of a tragic series of events in a cancer patient: an initial biopsy initiated needle track seeding. That is, a few cells trickled out of the biopsy needle, which acted as the mechanism of metastasis, and started new tumors, so they knew precisely when these tumors were initiated. This allowed them to use standard phylogenetic methods on sequences from samples of the cancer as it progressed, and put together a history of mutations for the diversifying cells of the cancer.

Chronology of the patient’s CRC evolution. (A) Whole-genome sequencing of multiple lesions from the patient’s malignancy allowed phylogenetic reconstruction of the tumour tree. In the phylogenetic tree, dates within brackets indicate the time of clinical diagnosis whereas dates in italic highlight the estimated times of the different lesions. (B) Illustrative cartoon of the patient disease progression and samples taken. At time tc the first colorectal cancer cell arose, giving rise to the primary tumour. At time tl the first metastatic clone emerged, giving rise to the lung metastasis, quickly followed by a second metastasis to the thyroid emerging at time tt . At time tcR the sample from the primary tumour was collected (resection) and analysed. During the lung biopsy, the needle tract seeding event spread cancer cells in the chest wall at time tcw. A few weeks later, at time tcR the lung metastasis was resected and profiled. Finally at time tcwR the chest wall metastasis was also sampled.

I know this excerpt from the paper is rather dense, but all you need to take away from it is that the different branches of the cancer pedigree have some common mutations, and also a constellation of unique mutations. Look, TP53, often called the “guardian of the genome”, is completely taken out with a missense mutation, and whole chromosomes show LOH (loss of heterozygosity) — that is, the cancer cells have lost entire copies chromosome 5, and in one subset, chromosomes 2, 9, and 22. This kind of wholesale chaos would not have been an adaptive response by a protistan ancestor.

Targeted sequencing of 409 cancer-related genes in both the primary CRC and all metastatic sites (lung, thyroid, chest wall and urinary tract) of our case revealed the presence of clonal non-sense mutations in APC (Gln1367*), as well as missense mutations in CTNNB1 (Leu156Gln), KRAS (Gly12Asp) and TP53 (Ser215Ile). The same mutations were not detected in the normal tissue or in the Hurthle adenoma. Two genes included in our panel showed discordance between primary and metastatic cancer: ADAMTS20, a metalloproteinase involved with cancer invasion and migration, and AKAP9 an A-kinase anchor protein which binds to the regulatory subunit of protein kinase A. The ADAMTS20 missense mutation Arg1885Thr was observed in the primary cancer but was not detected in either the lung, thyroid or chest wall metastases. Conversely, the AKAP9 missense mutation Ala3077Pro was found in all the metastatic sites but was not detected in the primary cancer. All these mutations were also found using WGS [Whole Genome Sequencing], furthermore ADAMTS20 and AKAP9 were validated by Sanger Sequencing. All lesions were microsatellite stable (MSS). Copy number analysis based on WGS data revealed a relative low level of chromosomal instability (CIN), with LOH of chromosome (chr) 5, gain of chr7, and a focal amplification on chr13q12.2-12.3, encompassing the VEGFR1 and CDX2 genes. These aberrations were clonal in all the CRC lesions, whereas the Hurthle adenoma showed a distinct profile characterized only by loss of chr2, chr9, and chr22. Primary tumour and metastatic sites displayed the same dominant, age related, mutational signature 1 which has previously observed in CRC as well as other cancer types.

Now that’s interesting stuff. Unfortunately, one of the lessons learned from analysis of other cancers is that every cancer is different — there are common modalities, such as the loss of certain checkpoint proteins, but there are multiple ways to achieve certain outcomes, and they don’t have to appear in any particular order. It definitely looks far less like a reactivation of a specific ancestral state and more like a derangement of regulatory functions.

Davies’ approach is kind of silly, too, a test designed to give whatever results the researchers want, with a set of observations that were basically a given with their parameters. For example, a lot of cancers mess up cell signaling to trigger uncontrolled growth. The signaling molecules are often factors like receptor tyrosine kinases (RTKs), which are only found in multicellular animals and one group of protists. So yes, it’s inevitable that you’ll find a lot of “young” (less than a billion years old) genes among your cancer-causing candidates. That observation does not support the idea of cancers being atavisms.

The Trump voter

And here we have the perfect apotheosis of the Trump voter, a small resentful man finding satisfaction by berating a Muslim family and thinking himself bigger because of his religion and his president.

In the viral video, Downing is seen with a clear plastic cup while shouting Donald Trump is my president! and You can try to act like you’re innocent. You can try to fuck with me, but guess what? You will never, ever, ever stop me. My Christianity will rise above your Sharia law. Your Sharia law … don’t mean shit to me!

And here is the next stage in the development of the Trump voter: crying in jail.

You know, since Jeff Sessions wants to keep those for-profit prisons full, maybe he should start jailing more Republicans.

Friday Cephalopod: that’s the weirdest octopus I’ve ever seen

This is the Octoprof. Do not be shocked at its frightful appearance.

The Octoprof is a Lesser Blue-Ringed Octopus (Hapalochlaena maculosa), who is a postgraduate at the University of the Gulf of Mexico, Shallow Waters (not her native habitat; she’s Australian, but emigrated to be closer to larger populations of her research subjects). Her focus of study is the reproductive biology of the invasive terrestrial species Homo sapiens – an animal which has of course been a source of tremendous concern amongst terrestrial biologists over the past thousand-ish lunar cycles, especially those whose research has a conservation focus.

Owing to a peculiar birth defect which gives her a faint but noticeable resemblance to the detested Homo sapiens (she has a serious malformation of the mantle and of two of her tentacles, which gives her a ‘face’ and ‘hands’), the Octoprof feels a strong and frankly embarrassing affinity for her research subjects. She has been criticized heavily for this unprofessional attitude by her fellow academics, most of whom would understandably prefer all research funds concerning homo sapiens to be focused on eradication measures.

It’s going to appear at the Minnesota Fringe Festival, 3-13 August, and is apparently trying to raise money to attend the event. I hope it can raise a surplus and use the excess to pay for cosmetic surgery.

How does it breathe? I don’t see a siphon, unless it’s those two tiny holes in the front of its cephalon — they’re so small it certainly can’t use them for propulsion. Poor thing.

Calling them transphobic is exactly like dropping a nuclear bomb on them!

I think I know what a metaphor is. It’s where you use a word or phrase that is symbolic of a situation, but isn’t literally a description. It is a comparison of one thing with another thing. You can use a metaphor to relate something abstract or unfamiliar to a concept a person is more comfortable with; hence the too-frequent comparison of the genome to a blueprint. From that example, you can see that a metaphor isn’t necessarily true, and can be misleading.

Another use of the metaphor is for exaggeration. For instance, if a student failed my genetics class, they could make the excuse “The prof was slaughtering students left and right! It was a Holocaust in there!” Perhaps it would be used for comic effect, but even at that, it’s dangerous: the student has both exaggerated the consequences of the course, and has seriously minimized the outcomes of the actual Holocaust. I trust most of you would be conscious of error in making that comparison. The result would not be to think the student is amusing, or to think that I was actually a brutal, unfeeling teacher, but to think that the student was a privileged young asshole. (None of my students have ever said such a thing — this is a purely hypothetical example.)

So what are we to think of the phrase “witch hunt”? There were real witch hunts, although there have never been any people with Satanic powers. As many as a hundred thousand innocent people in early modern Europe and America were falsely accused, tortured, and murdered in horrific ways. People still get accused of witchcraft, the Bible is still used to justify killing people for consorting with the Devil (who does not exist), and there are still benighted parts of the world where people are brutalized and killed for an imaginary crime. Every time you use the phrase “witch hunt” to describe an activity that has no chance of a victim ending up hanged or on fire, you’re diminishing the horror and desensitizing people to an openly evil history and an ongoing crime.

Yet for some reason it has become the first resort in any argument about merely academic dissent. Here’s a fantastic example: an academic wrote an article comparing “transracialism” to “transgenderism”. This is a bad, misleading metaphor, rather like comparing DNA to a blueprint, and people objected. I think it’s fair that sloppy scholarship ought to be vigorously criticized. So a letter was written.

While it is not the aim of this letter to provide an exhaustive list of problems that this article exhibits or to provide a critical response, we would like to note a few points that are indicative of the larger issues. We believe that this article falls short of scholarly standards in various areas:

1. It uses vocabulary and frameworks not recognized, accepted, or adopted by the conventions of the relevant subfields; for example, the author uses the language of “transgenderism” and engages in deadnaming a trans woman;

2. It mischaracterizes various theories and practices relating to religious identity and conversion; for example, the author gives an off-hand example about conversion to Judaism;

3. It misrepresents leading accounts of belonging to a racial group; for example, the author incorrectly cites Charles Mills as a defender of voluntary racial identification;

4. It fails to seek out and sufficiently engage with scholarly work by those who are most vulnerable to the intersection of racial and gender oppressions (women of color) in its discussion of “transracialism”. We endorse Hypatia’s stated commitment to “actively reflect and engage the diversity within feminism, the diverse experiences and situations of women, and the diverse forms that gender takes around the globe,” and we find that this submission was published without being held to that commitment.

Savage! Vicious! In an academic way, anyway. It never quite rises to the level of suggesting the rack, thumbscrews, or drawing and quartering, though. And yet, in an article titled This Is What a Modern-Day Witch Hunt Looks Like, it’s bluntly stated that…

This is a witch hunt.

Well.

Really?

It sort of takes one’s breath away. I guess you can call me Matthew Hopkins, the Witch-finder General, since I sometimes write strongly worded, angry criticisms of bad politics and stupid science, which is now apparently completely equivalent to the torture-murder of innocent women. We’re supposed to completely ignore the fact that poor scholarship of the sort being criticized actually does real harm to people, people who are often already marginalized and oppressed.

At least there’s one funny bit here. These same people who like to fling about the phrase “witch hunter” with indiscriminate abandon, and casually minimize the suffering of accused “witches”, are sensitive to another word: go ahead, call them “transphobic” and watch them squawk. How dare you insult them?

Our American madness

While our congress pats itself on its fanatical dedication to gutting health care, women are dying. This is a chart of maternal mortality in pregnancy per 100,000 live births.

Our health care system, among many other things, is broken. It is not the will of God or manifest destiny or any kind of positive American exceptionalism, because as the chart clearly shows, other countries do not have this problem to the same degree we have, and while they’re working to improve public health, we’re doing our damnedest to worsen it.

Thanks, regressive Republican vermin. You’re all traitors to humanity as well as to your country.