I always wondered how you can be a university president & on the board of pharmaceutical companies & run a gigantic research lab

I know that guy! That’s Marc Tessier-Lavigne! He’s about my age, and we shared similar interests — we were both interested in axon guidance, and I followed his work avidly some years ago. He was publishing about netrins, signaling molecules that affect the trajectory of growing neurons, while I was studying growing neurons in grasshopper embryos. I met him several times, I attended talks he gave at various meetings, it was hard to avoid Tessier-Lavigne.

Our careers followed very different paths, though. I ended up teaching at a small liberal arts college, while he got a position at UCSF, and then was CSO at Genentech, and then was president of Rockefeller University, was on the boards of various pharmaceutical companies, and finally was president of Stanford University. He was a major go-getter, running gigantic factory-style labs, getting regularly published in Science and Nature and Cell. It was a life that looked horrible to me, just as my life of obscurity and teaching would have looked horrible to him, if ever he had deigned to notice me.

Why would I have disliked the prestigious path he took in science? Because he turned himself into a manager, a guy who was disconnected from the science that was being done in his massively well-funded labs. Ick. I’d rather play at the bench and help students get enthusiastic about doing science.

I may have chosen wisely, because now Tessier-Lavigne has been compelled to resign as an investigation found evidence of fraud in his work. Yikes. This is bad.

The Board of Trustees’ inquiry stopped short of accusing Tessier-Lavigne — who has been Stanford’s president since 2016 — of fraud, saying there’s no evidence he “personally engaged in research misconduct.”

However, it was concluded that five papers on which Tessier-Lavigne was a principal author included work from “some members of labs overseen by Dr. Tessier-Lavigne” who had “either engaged in inappropriate manipulation of research data or engaged in deficient scientific practices, resulting in significant flaws in those papers.”

When the issues emerged, “Tessier-Lavigne took insufficient steps to correct mistakes in the scientific record,” the board’s report said.

This is what happens when you become an over-worked administrator with your fingers in too many pies. That does not excuse him — he has his name on so many papers, and getting an authorship entails significant responsibilities — and it just tells you the kind of peril ambition can put you in.

I’ve been teaching about netrins and robo and neuropilins and all these molecules in neurodevelopment for years. Am I going to have to put an asterisk by the source papers and review their validity now? I’m hoping the descent into sloppiness was a late-career problem that doesn’t call into question all the fundamental stuff he did.

Progress in embryo analysis!

Our new development in spider development is pretty basic stuff. We’re dechorionating embryos! That is, stripping off a thin membrane surrounding the embryo, so we can do staining and fixation and various other things. It’s a standard invertebrate technique — it turns out you can remove it by just washing them in bleach. Look, it works! This is a Parasteatoda embryo.

We’re still tinkering with the timing of the treatment. Five minutes is way too long, which basically dissolved the whole embryo. All it takes is a brief wash to break the chorion down. We’re also working out methods for manipulating them — they’re tiny! Just pipetting them into a solution is a great way to lose them. We’re now using a cut off microfuge tube to make a cylinder that we cap with a sheet of fine nylon mesh, to lower them into the solution. Of course, then we have to separate the embryos from the mesh. Fortunately, we opened up one egg sac and 140 embryos rolled out, so we have lots of material to experiment on.

The next question is whether they survive our abuse. We’ve got some of them sitting under a microscope, time-lapsing their response. We’ll see if they grow…or die and fall apart.

Being a good scientist might be harder than you think

You know, this guy was a terrible scientist by most criteria

The ideas in this paper, Ten simple rules for socially responsible science, ought to be explicitly spelled out in any grad program, especially since many of the incentives in science careers tend to oppose their rules. Read the whole thing, but here are a few of my comments on their list.

Rule 1: Get diverse perspectives early on

Some people seem to believe in the myth of the lone genius who comes up with brilliant ideas and executes them…and then gets a Nobel prize. It doesn’t work that way. Ever. It’s totally collaborative. In my classes I literally force students to work in teams in the lab, and there are always a few students who insist on going it alone. That’s missing the point!

Rule 2: Understand the limits of your design with regard to your claims

It’s tempting to go too far and make extravagant justifications for your work. Studying spiders will lead to a cure for cancer! Not really, but it would be a big boost to getting grant money if it were true.

Rule 3: Incorporate underlying social theory and historical contexts

I’ve experienced this unfortunate attitude that the only work that matters is stuff that’s been published in the last five years. I’ve had students ask me if it was OK to cite a paper from 1991 in their thesis project. Yeah? Why not? I cited papers from the 19th century in my PhD thesis! Dig deep, go interdisciplinary, drink from the Pierian spring, it’ll make your work better.

Rule 4: Be transparent about your hypothesis and analyses

Obviously. An experiment is not a fishing expedition.

Rule 5: Report your results and limitations accurately and transparently

Uh-oh. It’s shocking that we have to spell that out.

Rule 6: Choose your terminology carefully

This is about jargon. I’ve written a few things where I’ve totally lost people because they don’t know what I’m talking about. It’s also very common for me to make lots of comments in first drafts of student papers that they need to spell out that acronym and need to explain their terminology.

Rule 7: Seek a rigorous review and editorial processes

It’s common to see resentment at reviewer comments, and sometimes they are wrong…but you have to try and see it as a process to improve your work. That’s hard, though, especially if you’ve got a job that only cares about the volume of papers pumped out. Administrators do not read your work for quality.

Rule 8: Play an active role in ensuring correct interpretations of your results

That’s a good idea. Science isn’t fire-and-forget, a paper is a long-term commitment to a set of ideas that may need defending. Also, to be honest, few people will actually read your paper — your bigger audience is the people who come to your public talks or hear your interview on NPR or read the blog post summarizing it.

Rule 9: Address criticism from peers and the general public with respect

Awww, do we have to? Yes. That “peer” specifier is critical, though: I’m not going to treat creationists, anti-vaxxers, or climate change deniers kindly.

Rule 10: When all else fails, consider submitting a correction or a self-retraction

You’d have to do that less often if you heed #1, #5, #7, and #8, especially #7.

Most of the web advice I see about how to be a good scientist involves basic personal attributes: curiousity, observational skills, quantitative measurements, etc., and all that is true, but you don’t see much about all the essential aspects of being a cooperative community member. Maybe if we spent more time on that in early education we’d have fewer sociopaths.

Nah, there’s no cure.

Variation is wonderful

I’m stealing a fascinating thread on Twitter from Kathleen DePlume. In some ways, it’s unsurprising: if you compound the natural variation in enough parameters, you’ll discover that everyone is unique. It’s a question of including broad tolerances, and the real question is…how broad do they have to be to accommodate 99% of humanity? And another question would be…don’t the remaining 1% deserve a place as well? The math is nifty but it isn’t the whole of human reality.

So, did you ever wonder why car seats and seatbelts are so wonderfully adjustable? It all goes back to cockpit manufacture.

The USAF wanted to make aircraft with seats and belts fitted to the “normal” airman; the tolerances weren’t too wide, but lots of fellas are normal, right?

Wrong.

As it turned out, hilariously wrong.

You see, they measured several thousand enlisted men (just men – these were the dark times before women were people) on just a few things.

Leg length, knee to ankle, hip to knee, various seat measurements. Seating height to shoulder.

Shoulder width. Arm length. Shoulder to elbow, elbow to wrist.

You get the point.

Measurements that would allow the cockpit and belts to be correct and safe, as long as they were “close enough” to the normal specifications.

So, after taking these measurements – a great undertaking, the measures got so good at it that they could do all 38* measurements in under 2 minutes – they analysed the data.

*I might be misremembering the exact number

They figured if every measurement had tolerances that fit 30% or so “normal” men, then they’d lose a few percent to the abnormally shaped weirdos (you know the ones – people whose arms are way longer than their height, or who have tiny hands compared to their feet?) they’d still fit at least 20% of their potential pilots into the custom measured Everyman cockpits, right?

Wrong.

So, so very wrong.

How many pilots do you think fit in the normal measurements on all 38 metrics?

Go on, take a guess. I’ll wait.

Actually, no I won’t, because I’m writing this as a thread.

Zero. The answer is zero.

Not a single soldier was within tolerances on all measurements.

Out of thousands and thousands of airmen measured, every last man was abnormal on at least one.

It turns out that while yes, arm length and leg length aren’t exactly independent (if you’re tall you probably have long arms AND long legs), their r-value isn’t anything like high enough for the purposes the Air Force had in mind. They’re probably long by different amounts.

So it isn’t as simple as going 0.3^38 (a number so small it should be obvious it’ll round to 0), it also wasn’t what they assumed (0.3x [almost 1]^37).

It was somewhere in between.

Okay, so where did that leave them?

It left them knowing with utter certainty that they could not design a static cockpit and recruit airmen to fit it.

They had to go the other way. Broaden the tolerances – make it so they could account for broad differences in measurements.

They had to invent adjustable seats. Adjustable straps for the safety harnesses, seats that could travel back and forth a little bit, that sort of thing.

Okay, but how does this relate to cars?

Well, there’s the obvious: once it’s been invented, why not use it in cars? But the older folk among us probably remember bench seats, and maybe even a time when you didn’t put your seatbelt on because you were insulting the driver if you did.

What changed?

Funnily enough, another clever statistician.

This one was tasked with keeping very expensive pilots alive after the Air Force had spent so much money training them up. He was supposed to be looking at the safety equipment within planes, but this was after the war, so…

…pilots weren’t actually dying in the air that much.

Mostly what killed dashing young men back in those days was car crashes.

So the statistician came back with the findings that pilots would live longer if they were forced to wear their damned seatbelts when driving.

Funnily enough, this was a huge part of the impetus to make it law that all passengers have to wear belts in cars.

It’s only sensible – but humans seldom do sensible things unless forced. And pilots are very much human.

So we all wear seatbelts now because pilots are expensive.

The moral of all this?

Mostly that maths is interesting; but also that if someone is jumping up and down demanding their right to call themself “normal”, they are full of sh*t and don’t know what they’re talking about.

Mathematically speaking.

Unfortunately, the thread lacks any mention of sources. I’d want to know a lot more about it before I could cite it as interesting history without any caveats.

Wisconsin isn’t a popular site for reality

I wish we could vaccinate some people with a heavy dose of reality.

The state next to mine, Wisconsin, has gone insane. The raging anti-vax hysteria

The Republican-controlled Wisconsin Legislature on Wednesday voted to stop Democratic Gov. Tony Evers’ administration from requiring seventh graders to be vaccinated against meningitis.

The state Senate and Assembly, with all Republicans in support and Democrats against, voted to block the proposal. There is no current meningitis vaccination requirement for Wisconsin students.

The Legislature’s vote also makes it easier for parents to get an exemption from a chicken pox vaccine requirement that is in place for all K-6 students. Evers’ administration wanted to require parents seeking a chicken pox vaccination exemption to provide proof that their child has previously been infected.

WHY? These are well-established, safe vaccines against terrible diseases. They work. But somehow, Republicans have got it in their heads that reasonable evidence-based medicine is bad.

This is getting personal, too. My daughter and son-in-law and my little 4 year old granddaughter all live in Wisconsin, and she’ll be attending Wisconsin public schools in a year. I don’t want her to get chicken pox or meningitis. Of course, I trust her parents to get her vaccinated even in the absence of a public health requirement — it’s all the other kids we have to worry about.

The incentives are all wrong

Meat “scientist”

There are scientists I respect, and there are scientists I do not. José Manuel Lorenzo is in the latter category, although I’m sure he wouldn’t care. He’s rolling in the money and the false coin of scientific “prestige”.

Meat expert José Manuel Lorenzo, 46, is the researcher who has published the most scientific studies in Spain. He put his name on 176 papers last year, according to a count by John Ioannidis — an expert in biomedical statistics at Stanford University — which was requested by EL PAÍS.

Lorenzo publishes a study every other day (if you include weekends). It’s an astonishing figure, far above the second-highest ranked scientist: the prestigious ecologist Josep Peñuelas, 65, who published 112 studies in 2022

I’m trying to picture the logistics of all that. It typically takes a month or more to get a paper published, and that’s if there are no revisions or rejections. I’ve heard of high priority, dramatic results getting a turnaround of a week or so — maybe trash papers that no one cares about similarly get rapid publication. At any rate, it must mean he’s got dozens of papers stacked up in a queue at any one time. How does he find time to cope with revisions, let alone actually write them? Forget about actual research. The “evidence” backing up the claims that warrant a publication would have to be done in a day or two!

Oh wait, there is a way. Don’t do the research, don’t do the writing, and don’t even read the papers.

José Manuel Lorenzo is the head of research at the Meat Technology Center (CTC) — an entity dedicated to meat products, supported by the regional government of Galicia — in San Cibrao das Viñas, a city in the Spanish province of Ourense. A person who has worked with him recalls that, around 2018, his laboratory became “a sausage factory.” Lorenzo went from publishing less than 20 studies a year to signing his name to more than 120. “He doesn’t even have time to read them,” says another person, who has collaborated on projects with the man.

At one point, Lorenzo began collaborating with exotic researchers — who nobody knew about — on topics that have nothing to do with meat. Four months ago, he published a study on the hospital management of monkeypox, alongside Iraqi, Indian and Pakistani co-authors. And a year ago, he and some researchers from India and Saudi Arabia published an article on the treatment of gum disease with bee venom. In a telephone conversation with EL PAÍS, Lorenzo admits that he doesn’t know any of these co-authors in person, nor is he an expert on any of these issues.

That’s a serious lack of integrity he is admitting to. I was trained to understand that if your name was on a paper, you were expected to have contributed significantly to the work, and are familiar with the entirety of the procedures and results. You are responsible for the content of the paper. You can be held accountable for any errors, or worse, any fraud. It’s supposed to be a weighty thing…but not to Lorenzo.

One tool that allows this to go on is the existence of paper mills.

India is one of the countries where so-called “paper mills” are concentrated — factories that churn out scientific studies which are already written and ready to be published in specialized journals. Co-authorship is offered in exchange for money. EL PAÍS requested price rates from one of the Indian companies that sends their offers to Spanish scientists: iTrilon, based in Chennai. The company’s scientific director Sarath Ranganathan offered the possibility of being the first author of a study that was already written — entitled Next-generation neurotherapies against Alzheimer’s — in exchange for about $500. It’s also possible to be the fifth co-author of an article titled Emergence of rare microbial infections in India for $430. iTrilon promises to publish these ready-made studies in the journals of the world’s leading scientific publishers: Elsevier, Taylor & Francis, Springer Nature, Science and Wiley. Last year, the academic publishing industry acknowledged that at least 2% of studies each journal receives are considered to be suspicious. Sometimes, the number of suspicious studies is marked as high as 46%.

Another factor is that grant review and institutional committees are far too willing to do little oversight and superficial evaluation. The problem is that we assess scientific work based on publication, which is already poisoned by capitalism and exploitation, and not by being read.

Although, I must admit, I can understand how someone might be tempted by $400 or $500 flowing into one’s bank account every two days just for rubberstamping a stupid paper.

Another stereotype squashed by the evidence

An Awá woman holds hunting bows and arrows in Brazil’s Caru Indigenous Territory in 2017

A thousand just-so stories have suddenly cried out in shock and died a miserable death. Hunter-gatherer societies don’t think that hyphen separates men from women? This is what you learn when you don’t do your anthropological research by surveying Psych 101 classrooms in Western colleges. These researchers actually did a world-wide survey of foraging cultures!

For decades anthropologists have witnessed forager women—those who live in societies that both hunt and gather—around the world skillfully slay prey: In the 1980s, Agta women of the Philippines drew bows and arrows as tall as themselves and aimed at wild pigs and deer, and Matses Amazonians struck paca rodents with machetes. Observations from the 1990s described Aka great-grandmothers and girls as young as age 5 trapping duiker and porcupine in central Africa.

A study published today in PLOS ONE has united these reports for a first-of-its-kind global view of women hunters. Reviewing accounts penned by scholars who study culture, known as ethnographers, as well as those by observers between the late 1800s and today, the researchers found that women hunted in nearly 80% of surveyed forager societies.

These data flatly reject a long-standing myth that men hunt, women gather, and that this division runs deep in human history.

It makes sense. You’re not going to tell half your community that they can’t exploit a rich and highly-valued food source, so of course women would poke tasty animals with sticks when they could. Restricting women’s choices is a pathological condition that could only be tolerated in a wealthy society with a wasteful surplus already. There were some gender differences, and hunting was a wholesome activity that could be enjoyed by the whole family!

The reports also revealed considerable flexibility and personal preferences, both within and across cultures. Individuals wielded various weapons including spears, machetes, knives, and crossbows. Some relied on hunting dogs, nets, or traps. Women followed tracks to big game and beat the ground with sticks to flush out critters. Child care posed little problem: Mothers carried infants or left them at camp with other community members; older children often tagged along, hunting as well.

The team did discover differences between male and female strategies. For example, among the Agta, men almost always wielded bows and arrows, whereas some women preferred knives. Men were more likely to head out solo or in pairs, whereas women generally hunted in groups and with dogs.

Despite gender differences, the team found little evidence for rigid rules. “If somebody liked to hunt, they could just hunt,” Wall-Scheffler says.

That’s just what people do. But what about the CHILDREN?

Suggestions that children are put in danger by accompanying hunts can be mediated with current literature on the numerous ways in which infants and children are carried during expeditions by parents and alloparents. The importance of infants remaining with adults (versus being parked) is an important part of our lineage, with children accompanying the wide range of expeditions consistently evidenced in the archaeological, as well as the ethnographic record. Data explicitly mentioning that infants are carried while hunting exist for the Aka and the Awa, as well as for foraging bouts that might result in opportunistic hunting (e.g., among the Batek and Nukak). Among both the Hadza and the Aka, children (potentially as young as age three) accompany adults on over 15% of hunting trips. The idea that women are hindered by childcare and thus cannot hunt is an area where increasing data collection and thoughtful interpretation is lending a much richer lens to our understanding of human mobility strategies.

But what about vegetarians?

Moral panics and the bigoted subversion of biology

Fresh off that paper about how the liberals are destroying “merit” and science, Jerry Coyne fearlessly rides his hobby horse onto the pages of the Skeptical Inquirer, where he complains about a a grave threat to biology. That threat? Ideology and dogma are strangling research and scientific communication. Scientists are too cowed to speak their minds. Well, except for Jerry A. Coyne and his coauthor, Luana S. Maroja, who are willing to confront the dogma of the Progressive Left.

It’s somewhat peculiar to read the complaints about a dogmatic stranglehold from these people. Coyne is a well-known, established, and successful scientist — he is a graduate of Harvard, and is now an emeritus professor of the Department of Ecology and Evolution at the University of Chicago, one of the most prestigious institutions of evolution research in the country. Maroja is a full Professor of Biology, and Chair of Biochemistry & Molecular Biology Program at Williams College. I don’t see how they can complain that their careers have been “strangled” by the Left.

Coyne and Maroja are the establishment.* Their careers are built on convincingly supporting the dogmas of biology (which is not necessarily a bad thing at all.) They have immense amounts of academic power and influence, and have far more potential to be the strangler, rather than the strangled. Yet somehow they have the idea that science is being politically purged by progressive social justice, which they claim doesn’t care about truth.

That’s a remarkable claim, fundamentally paranoid and conspiratorial, and I’m going to have to see strong evidence to support it. Coyne and Maroja write that they have six specific examples from just their field of evolutionary biology — examples of leftists distorting biology and altering education and devaluing “merit.”

Let’s see it. They’re going to give us six examples of “misstatements spread by ideologues” that they believe are impeding science.

1. Sex in humans is not a discrete and binary distribution of males and females but a spectrum.
Coyne & Maroja claim this is false because there are only two kinds of functional gametes, sperm and eggs, and therefore there can be only two sexes. The claims of gender ideologues can be trivially dismissed because they can’t trot out a third kind of gamete, or can’t name all the other sexes. Furthermore, people aren’t assigned sex at birth, so it is not a sexual construct, but rather, sex is an observation of biological reality.

The Coyne & Maroja argument is nonsense at every level. First, we humans are not our gametes — we are complex multicellular organisms. To argue that gametes are definitive is a gross oversimplification that ignores physiology, behavior, psychology, and culture, all of which are affected by sex. This is an example of extreme reductionism.

It’s also an argument designed to misrepresent and distort the positions of their critics. No one is arguing that there are other kinds of gametes; trans men and women are not claiming to have transformed their gametes to some other form, and the ones I’ve talked with are acutely aware that their gonads do not metamorphose. Trans men may still be capable of pregnancy, trans women will not ovulate, and they do not pretend otherwise. This is the kind of argument that shows that the ones proposing it are totally unaware of the nature of trans culture, they are arguing against a proposition that no one is making.

As for the claim that the definition of sex at birth is simply a biological observation…well, that wrecks their premise, because the sex of a baby is not a question of what kind of gametes they are producing. It’s a superficial examination of morphology. You can have a penis or vagina without any correlated gamete production!

Here’s what I, a biology professor and progressive Leftist, teach in my classes.

Biological sex is the product of a complex cascade of molecular and cellular activity in embryonic development that continues for decades — for the entirety of an individual’s life, in fact — and there are multiple opportunities for variation. These variations can accumulate to produce a continuum of outcomes, so that the broad categories of men and women encompass a vast diversity of human forms and ideas and behaviors.

I would say that claiming that humans are trivially reducible to two simplistic categories is the greater distortion of biological facts and diminishes the evolutionary consequences of the differences within a sexual category.

Do Coyne & Maroja do a better job of explaining and dismissing the second misconception of those progressive leftists? No, they do not.

2. All behavioral and psychological differences between human males and females are due to socialization.

While you might be able to find a few fringe individuals who espouse that view, it’s not at all representative of what academic biologists — or even the majority of informed laypersons — think. This is a common pattern in the Coyne & Maroja review, though, misrepresenting the perspective of the people they critique by inventing a straw man argument. They go on to cite Pinker’s book, The Blank Slate, as if it were a fact-based source of data rather than a subjective and dishonest mess of prejudicial assertions. The biologists I know would laugh at this notion that people are blank slates.

Rather than citing an unqualified non-biologist to tell us what biologists think, I’d recommend instead Lewontin’s The Triple Helix, which is far more representative. Lewontin explains that the evolution of individuals is explained by the interplay of genes, organisms, and the environment. Note that genes are part of the equation, a significant part, but that you can’t explain genetics except in the context of their environment.

It’s a little surprising that they ignore this common view, since Lewontin was Coyne’s mentor at Harvard.

So what would this deranged Leftist teach in his biology classes?

There are clear average differences between men and women, but the attempt to tease them apart into purely biological and purely cultural differences is a futile exercise, often ideologically motivated. Biology and culture are inseparable, and what makes you you is a complex pattern of interaction between the two.

3. Evolutionary psychology, the study of the evolutionary roots of human behavior, is a bogus field based on false assumptions.

Great. On this one, he cites me directly as the purveyor of this supposedly misguided claim. I wrote, “The fundamental premises of evo psych [evolutionary psychology] are false,” which is accurate, I did say that. I also said a lot more, explaining what those faulty premises are…but Coyne & Maroja omit that, for some unexplainable reason. Instead, they come up with an anodyne definition of evolutionary psychology: our brains and how they work–which yield our behaviors, preferences, and thoughts–sometimes reflect natural selection that acted on our ancestors.

One problem here is that I agree with that sentence, so once again, they have invented dissent where none exists and have hidden away the problem with evolutionary psychology. The idea that genes and evolution have shaped our behavior is accepted and not at all problematic, but Coyne & Maroja assert that opponents of evolutionary psychology deny the role of evolution on behavior.

Bluntly, that is an outright lie.

They think they can get away with it because they’ve obscured what premises of evolutionary psychology I consider false. It’s a quote mine.

Where I consider evolutionary psychologists to fail is in methodology and poor theory — they take the unjustified shortcut of assuming any modern behavior is the product of genetic traits that were locked in place in the Pleistocene, and are always the product of selection, and that therefore any hypothetical selective scenario they invent is valid and worth publishing as science. They seem to be entirely oblivious to alternative modes of evolution, treating natural selection as the only significant force, ignoring the facts of drift and migration. They are masters of the just-so story, building hypotheticals about ancient human ways of life and ‘testing’ them with surveys of middle-class students enrolled in Psych 101 courses.

I do not deny that human biology and behavior are the product of evolution, but rather that evolution is more complex than evolutionary psychologists imagine it to be, and that the tools of psychology are sadly inadequate to address the problem.

What I teach in the classroom:
Every species is the product of a long history of evolutionary forces, and those forces involve more than just a cartoonish idea of endlessly optimizing selection. You’ve learned about nearly-neutral theory, about lineage analysis, about the mathematics of comparing traits (they would have gotten all that in even my introductory classes), and that accurately determining the evolutionary trajectory of a population requires detailed measurement and observation and rigorous mathematical analysis. Please do apply what you’ve learned to behavior and psychology, but do it better than the evolutionary psychologists have.

4. We should avoid studying genetic differences in behavior between individuals.

Oh dear. Oh dear oh dear oh dear. In this section, Coyne & Maroja plunge into the world of the genetic basis of IQ scores and educational attainment and are saying that we should study genetic differences in the minds of people. The problem with that, and the reason we should discourage that kind of research, is that it inevitably leads to garbage science. Weak correlations will get used to prop up all kinds of biases. That’s why this topic is so popular among right-wing zealots and racists. They say,

This kind of study (genome-wide association studies, or GWAS) has, for example, turned up nearly 4,000 areas of the genome associated with educational attainment. Fascinatingly, many of these genes are active mainly in the brain. Using GWAS studies, it’s now possible to make fairly accurate predictions about a person’s appearance, behavior, academic achievement, and health simply by analyzing the DNA of an individual and calculating their individual “polygenic scores” based on large samples of their population.

No, you can’t do that.

GWAS are basically fishing expeditions — you search for correlations between genetic markers and social or behavioral phenomena. It might be useful when coupled to specific, prior hypotheses, but much of it is grinding through thousands of statistical correlations and grabbing any that rise above a chosen chance criterion. It can be hopelessly noisy. Look at the result of GWAS of “educational attainment” (already, a uselessly broad category): 4000 “areas” (not genes, just broad chunks of chromosomes) are somehow associated with learning, and we can at best say that many are active in the brain. Almost everything is active in the brain! Almost everything is active in the pancreas! Sorting out what is relevant is the problem, and we’re nowhere near achieving that.

There is such a volume of potential correlations that it may well be that most of what GWAS are picking up are accidental correlations by lineage — that is, the parameter is common among certain groups of people not because it plays a role in, for instance, intelligence, but because the people showing that trait are related. The danger is that, for example, you might think you’ve found a gene associated with the success of a certain group, but it’s only a coincidence and is actually irrelevant. Then that chance coincidence gets picked up as evidence of superiority of the tested group, and you’re off to the eugenics races.

It’s simply silly to suggest that we could feed a genome sequence into a computer, and it will then compute the organism. That’s genetic determinism, and it doesn’t work. Twins have strong physical similarities, but do twin pairs all share the same personality? I come from a blue collar family, generations of farmers and laborers, all good people but not really interested in things like college…I have to suspect that if universities had used a DNA sample as an admissions test, I’d be out picking fruit and plucking chickens in Yakima.

Coyne & Maroja are actually almost right in what I’d teach my classes.
We should avoid studying genetic differences in behavior between individuals, unless we have clear causal and functional information and specific hypotheses about the genes we are studying. Vague, sloppy generalizations will be abused!

5. Race and ethnicity are social constructs, without scientific or biological meaning.

Oh god, make it stop. Coyne & Maroja take a bold step in favor of race realism.

To be fair, they take a waffly stance, being ambiguous about how we ought to talk about ethnicities instead, about how many races/ethnicities there are, and how we can use race information to fine-tune medical treatments or even how we can solve crimes by reconstructing perpetrators from their genetic information (see previous section; no, you can’t). He uses these excuses to defend…Bo Winegard?

Indeed, even writing about this subject has led to sanctions on many scientists, who have “found themselves denounced, defamed, protested, petitioned, punched, kicked, stalked, spat on, censored, fired from their jobs and stripped of their honorary titles.” A well-known example is Bo Winegard, an untenured professor in Ohio who was apparently fired for merely suggesting the possibility that there were differences in cognition among ethnic groups. This is why most biologists stay far away from this topic.

“merely suggesting the possibility” is a curiously tepid way to describe a guy who openly describes himself as an “ethno-traditionalist”, “cultural nationalist”, and “racial realist” and who calls Arthur Jensen his “intellectual hero.” He’s a loud and proud racist who thinks white people are superior!

Here’s how I handle this in my classes:
Don’t be a fucking racist goober.

More seriously, in the last two weeks of my genetics course I gave the students a dozen peer-reviewed papers on how geneticists were addressing the issue of race, put them in groups, and had them give presentations on the papers they chose to discuss. Get into the literature, and you’ll discover most modern geneticists have little patience with so-called “scientific racism,” any more than they are interested in discussing “scientific creationism.” There are exceptions, obviously. Usually they’re posting on Quillette or other race-realist forums. Or publishing in Skeptical Inquirer or the Journal of Controversial Ideas.

6. Indigenous “ways of knowing” are equivalent to modern science and should be respected and taught as such.

On Coyne’s blog, he seems to be moderatly obsessed with New Zealand indigenous culture, thinking it compromises science, somehow. Maori culture is a complex mix of ideas.

Matauranga Māori, the indigenous way of knowing in New Zealand, is a mélange of empirical knowledge derived from trial and error (including the navigational ability of their Polynesian ancestors and Māori ways of procuring and growing food) but also includes nonscientific areas such as theology, traditional lore, ideology, morality, and legend.

That sounds like a liberal arts curriculum to me. Teach the history, the cultural practices, the religion and mythology…just as we do in Western societies. You can’t, for instance, teach the history of science without discussing Catholic theology and its contributions; you also can’t avoid discussing the oppressive aspects of a culture without also talking about art and beauty. I don’t see the problem, although I’m not familiar with the Maori.

I do teach at a non-tribal American Indian serving institution, though, and I think their concerns are overblown. The Lakota have a myth that their people emerged from a cave — they can even point to a cave in South Dakota called Maka Oniye as their origin. We teach this in our Indian Studies classes, since it is a lovely story and tells us about how the Lakota think of themselves (it also includes a spider god, Iktomi, which I find quite nice). But we don’t teach it in our biology classes. There are no angry Lakota citizens shaking their fists at us and demanding that we incorporate it into our curriculum. Perhaps Coyne is thinking that these indigenous peoples have the same fanatical certainty that Southern Baptists do. They don’t. They would just appreciate it if you showed a little respect for the people who were displaced by Western colonialism.

The only experience I’ve had with our Indian students that comes even close is that, several years ago, some visitors commented on the fact that we had a display of mounted owls at the entrance to our atrium, which was mildly offensive to Native Americans who regarded owls as symbols of death. So we moved them. It’s not hard to respect people’s beliefs, and it does no harm to the science.

No one teaches that cultural preferences are equivalent to what we teach in physics, chemistry, and biology.

Coyne & Maroja are also indignant about the idea of repatriation — that Native Americans are demanding the return of bones from museum collections. They don’t seem to appreciate that these remains were stolen, looted from grave sites, or even taken directly from murdered or executed Indians. I guess it’s true that we progressive lefties consider consent important, and that it even trumps Science.

I would just ask how they would feel about the Jewish skull collection that was to be displayed at the Reich University of Strasbourg after WWII (fortunately, a plan that was aborted by the Reich’s defeat). The bones were returned to their families, where possible, and re-interred. The situation is directly analogous to what Native Americans experienced, except that imperialist forces haven’t yet been defeated. Why is one case an example of basic human decency, while a horrible anti-scientific crime in the other?

How would I teach this? I don’t. I suspect Coyne & Maroja don’t, either, and that neither have had to accommodate Maori traditions, so it’s a silly thing for us to be concerned about. If I did teach something in the appropriate field, I would probably steal the words of Jennifer Raff, who studies paleogenomics.

Actually, repatriation laws have really enabled a lot of the work I and some of my colleagues do. A lot of my work in North America is on ancestral remains that have been returned to tribes. As part of that process, some tribal representatives have come to me and said, “We are interested in studying the DNA before we rebury our ancestors.” A lot of these remains have been languishing in storerooms, and as part of NAGPRA they’ve been cataloged and looked at and new things have emerged as a result. Human remains from Shuká Káa [formerly On Your Knees] Cave in Alaska, for example, were excavated with the cooperation of local tribes and showed people living in the area today are related to an individual who died 10,300 years ago.

It’s not anti-science to take the beliefs of the people you work with into account. It’s the racism and colonialism and sexism and pseudoscience that are anti-science. Raff is pointing out that respecting the people of the cultures she studies literally benefits the science.

I’ll have to stop here — this is already over twice the length of the response Skeptical Inquirer was going to allow me, so I don’t think there’s any point in trying to submit it to them. I do have to say a bit about Coyne & Maroja’s conclusion, because that’s where they let all the fascist paranoia hang out.

Progressive ideology is growing stronger and intruding further into all areas of science. And because it’s “progressive,” and because most scientists are liberals, few of us dare oppose these restrictions on our freedom.

What restrictions on our freedom? I can say what I think, Coyne & Maroja can say what we think, and the only cost is that we each think the other is an asshole. I can live with that. So can the Emeritus Professor and the Chair of Biochemistry & Molecular Biology. Of course, Coyne is only going to be able to publish this nonsense in not-very-distinguished journals. That’s fair, though, since his work clearly lacks merit.

And mainly what he’s going to do is complain about a nonexistent existential threat to all of science because it is infested with those dang liberals.

Unless there is a change in the Zeitgeist, and unless scientists finally find the courage to speak up against the toxic effects of ideology on their field, in a few decades science will be very different from what it is now. Indeed, it’s doubtful that we’d recognize it as science at all.

OK, now I’m inspired! I will continue to speak up against the toxic effects of conservative ideology on my field. You know, the ideology that would deny the existence of trans individuals; that advocates for genetic determinism; that thinks a sloppy science like evolutionary psychology that defies standard theory and practice is worthwhile; that promotes outmoded and dangerous ideas about IQ and the genetic basis of all behavior; that wants to return to an early 20th century version of race pseudoscience; and that thinks indigenous people who express their cultural beliefs ought to be silenced. Fine. I’ll declare that the Coyne & Maroja vision of science is broken and ultimately damaging. They represent old dogmas and tired ideas.

I do hope science is someday very different from the bad science that racists and sexists want to promote, and that the big change is that women and gay and trans people can work in science without old cranky scientists claiming that their existence does irreparable harm to the field.

Also, someday I hope staid old conservative skeptic organizations learn to recognize a moral panic when they see one and refuse to fuel it with more hysterical paranoia of the sort we see in the Coyne & Maroja article.


*By the way, so am I — I’m an old white heterosexual cis man. Isn’t it interesting how two people who belong to the same privileged demographic can have such radically different views?

90% of everything is junk

I read Larry Moran’s What’s in Your Genome?: 90% of Your Genome Is Junk this week — it’s a truly excellent book, everyone should read it, and I’ll be making a more thorough review once I get a little time to breathe again. Basically, though, he makes an interdisciplinary case for the sloppiness of our genome, and it’s all that evidence that we should be giving our biology students from day one.

Anyway, I ran into a similar story online. Everything accumulates junk, from your genome to my office to Google. Cory Doctorow explains how search engines are choking in their own filth.

The internet is increasingly full of garbage, much of it written by other confident habitual liar chatbots, which are now extruding plausible sentences at enormous scale. Future confident habitual liar chatbots will be trained on the output of these confident liar chatbots, producing Jathan Sadowski’s “Habsburg AI”:

https://twitter.com/jathansadowski/status/1625245803211272194

But the declining quality of Google Search isn’t merely a function of chatbot overload. For many years, Google’s local business listings have been terrible. Anyone who’s tried to find a handyman, a locksmith, an emergency tow, or other small businessperson has discovered that Google is worse than useless for this. Try to search for that locksmith on the corner that you pass every day? You won’t find them – but you will find a fake locksmith service that will dispatch an unqualified, fumble-fingered guy with a drill and a knockoff lock, who will drill out your lock, replace it with one made of bubblegum and spit, and charge you 400% the going rate (and then maybe come back to rob you):

https://www.nytimes.com/2016/01/31/business/fake-online-locksmiths-may-be-out-to-pick-your-pocket-too.html

Google is clearly losing the fraud/spam wars, which is pretty awful, given that they have spent billions to put every other search engine out of business. They spend $45b every year to secure exclusivity deals that prevent people from discovering or using rivals – that’s like buying a whole Twitter every year, just so they don’t have to compete:

https://www.thebignewsletter.com/p/how-a-google-antitrust-case-could/

I’m thinking I should advertise Myers Spider Removal Service on Google, and then I respond to calls by showing up, collecting a few spiders, bring them back to my lab, and increase their numbers a thousand-fold, which I then return to the house in the dead of night. Then they call me again.

Hey, it’s a business model.

The comparison of Google’s junk to our genome’s junk falls apart pretty quickly, though, because your cells have mechanisms to silence the expression of garbage, while Google is instead motivated to increase expression of junk, because capitalism.