Cloning as solace

You all may recall the memorable, late Tito the wonder dog. Hank Fox has done something thought-provoking: he has frozen away some of Tito’s cells, on the chance of cloning him.

At 325 degrees below zero, the essence of Tito sleeps.

I got a call today from Genetic Savings & Clone, the company that stores tissue samples of pets, and they told me the culturing of the samples I’d sent them was successful. I now have about 10 million cells waiting for the future moment — if ever — when the technology and the money coincide to allow me to clone him.

This is a personal decision, and I wouldn’t argue one way or the other about what Hank should do; it sounds like he’s wrestled over the issues already. All I can say is what I would do if I were in his sorrowful position.

I wouldn’t even try cloning.

I disagree with his first sentence up there: the essence of Tito isn’t reducible to a few million cells or a few billion nucleotides. While the genome is an influence and a constraint—a kind of broadly defined bottle to hold the essence of a dog—the stuff we care about, that makes an animal unique and special, is a product of its history. It’s the accumulation of events and experience and memory that generates the essentials of a personality and makes each of us unique.

Even if cloning were reliable and cheap, I wouldn’t go for it. It would produce an animal that looks like Tito, and would be good and worthy as an individual in its own right, but it wouldn’t be Tito.

Hank mentions that “Even we atheists grapple with mortality, and entertain hopes.” That’s true. But I think that what we have to do, the honest part of being an atheist, is to recognize that mortality is inevitable and that things end. Grief and loss are the terrible prices we pay for living in a world that changes, and that has produced us, so briefly. The dead are gone forever, never to return, and all we can do is fight as hard as we can to delay it, rage at our inevitable failures, and eventually, reconcile ourselves to the reality.

I think Hank is still fighting when the battle has already been lost. That’s a noble effort, I suppose, but Tito is not in that dewar of liquid nitrogen, I’m sorry to say.

Another Tuesday, another Café Scientifique

We’re having another Café Scientifique here in Morris this evening—come on down! Nic McPhee of the Computer Science discipline (who also has a weblog, Unhindered by Talent) will be discussing “Privacy, security, and cryptography: What happens to your credit card number on-line, and is that e-mail really from your boss?“. It is open to everyone, of course, and is being held at the local coffeeshop, the Common Cup, from 6:00 to 8:00 this evening.

Eight good essays on Mooney

There is a most excellent online seminar on Mooney’s Republican War on Science going on over at Crooked Timber. The usual gang is reviewing it, with the addition of the inestimable Tim Lambert and Steve Fuller. Wait a minute…Steve Fuller? That Steve Fuller? Steve Fuller. Steve Fuller!

Jebus.

I saw some glimmers of some interesting ideas at the start of Fuller’s ultimately long-winded essay, but they expired even before he started defending the “positive programme behind intelligent design theory” and collapsed into tired pro-creationism mode. When he called George Gilder and Bruce Chapman “technoscience sophisticates”, two people who know no biology and are proud of it, yet rail against basic evolutionary biology, I gave up. I don’t know what a contemptible pseudoscientific poseur like Fuller is doing in there, actually—maybe they should have invited Tom Bethell or some similar anti-science crank in, to give even better balance.

Oh, well. You can skip over that one. The rest of the online seminar is much more sensible.

Taxonomy of Biologists

As an exercise in futility, The Daily Transcript tries to categorize disciplines of the life sciences. Although there is a general air of truth to what he’s saying, the problem is that, unlike the members of the Tree of Life, academic disciplines are free to hybridize and accumulate and change, so instead of blurry but recognizable terminal branches, you end up with an anastomosing rete, and no one can sort out precisely who is what.

For instance, I’ve got training as a neurophysiologist (electrodes everywhere!), a cell biologist (painting organelles different colors and watching the glowing cells move), and a developmental biologist (which, contrary to Palazzo’s description, is actually the Most Important Discipline in Biology; he’s also wrong about killing fetuses, sometimes we just like to muck ’em up so they’re horribly deformed.) Oh, and I’ve had a smattering of genetics, but it was all developmental—real geneticists are kind of the mathematicians of biology, all very abstract and peculiar and mostly incomprehensible.

I also notice the bench biologist’s bias in his classification scheme. No ecologists? An article on taxonomy with no taxonomists?

That revolting article about earwax and smegma

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Not all the email I get is from cranks and creationist loons. Sometimes I get sincere questions. In today’s edition of “Ask Mr Science Guy!”, Hank Fox asks,

I was thinking recently about the fact that wax collects in one’s ears, and suddenly thought to be amazed that some part of the HUMAN body produces actual WAX. Weird. Like having something like honeybee cells in your ear.

And then I started to think about what sorts of other … exudates the human exterior produces. Mucus, possibly several different types (does the nose itself produce more than one type?). Oils, possibly several different types. That something-or-other that hardens into your fingernails. Saliva, if you wanted to count our frequently-open mouth as sort-of exterior. What else?

Of course I know something about this subject, having taught physiology for a few years. My years of experience have also led me to notice that it is always the guys who ask about disgusting secretions. Why is that?

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Chance and regularity in the development of the fly eye

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What has always attracted me to developmental biology is the ability to see the unfolding of pattern—simplicity becomes complexity in a process made up of small steps, comprehensible physical and chemical interactions that build a series of states leading to a mostly robust conclusion. It’s a bit like Conway’s Game of Life in reverse, where we see the patterns and can manipulate them to some degree, but we don’t know the underlying rules, and that’s our job—to puzzle out how it all works.

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Another fascinating aspect of development is that all the intricate, precise steps are carried out without agency: everything is explained and explainable in terms of local, autonomous interactions. Genes are switched on in response to activation by proteins not conscious action, domains of expression are refined without an interfering hand nudging them along towards a defined goal. It’s teleonomy, not teleology. We see gorgeously regular structures like the insect compound eye to the right arise out of a smear of cells, and there is no magic involved—it’s wonderfully empowering. We don’t throw up our hands and declare a miracle, but instead science gives us the tools to look deeper and work out (with much effort, admittedly) how seeming miracles occur.

One more compelling aspect of development: it’s reliable, but not rigid. Rather than being simply deterministic, development is built up on stochastic processes—ultimately, it’s all chemistry, and cells changing their states are simply ping-ponging through a field of potential interactions to arrive at an equilibrium state probabilistically. When I’d peel open a grasshopper embryo and look at its ganglia, I’d have an excellent idea of what cells I’d find there, and what they’d be doing…but the fine details would vary every time. I can watch a string of neural crest cells in a zebrafish crawl out of the dorsal midline and stream over generally predictable paths to their destinations, but the actions of an individual melanocyte, for instance, are variable and beautiful to see. We developmental biologists get the best of all situations, a generally predictable pattern coupled to and generated by diversity and variation.

One of the best known examples of chance and regularity in development is the compound eye of insects, shown above, which is as lovely and crystalline as a snowflake, yet is visibly assembled from an apparently homogenous field of cells in the embryo. And looking closer, we discover a combination of very tight precision sprinkled with random variation.

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Warring sexes

Both Twisty and Amanda seem a bit weirded out by this news that the fetus can be viewed as a kind of parasite. This story has been around long enough that a lot of us just take it for granted—I wrote about the example of preeclampsia a while back.

There are worse feminist-troubling theories out there, though. In particular, there is the idea of intersexual evolutionary conflict and male-induced harm. In species where there is some level of promiscuity, it can be to the male’s evolutionary advantage to compel his mate to a) invest more effort in his immediate progeny, b) increase her short-term reproduction rate, and c) suppress her ability to mate with other males. After all, his optimal strategy is to flit from female to female, copulate, and put her to work producing his offspring. The female’s preferred strategy, on the other hand, is to take her time, maximize her lifetime reproduction rate, and select the best genetic endowment for her children.

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This sets up a cycle of counter-adaptations in the population. If a male acquires a mutation that increases his fitness at the expense of his mate’s—for instance, if some component of his semen works on her brain to suppress her interest in remating—it will spread through the population due to its positive effect on male fitness, even though it reduces female fitness. Subsequently, a female who acquired a counter-adaptive resistance to the male’s hormonal sabotage would have an advantage, and that gene would spread through the population, reducing male fitness by making them less capable of controlling female reproduction. Then, of course, males could evolve some other sneaky way of maximizing their reproduction rate—vaginal plugs, secretions that make the mated female unattractive to other males, proteins that put her ovaries into overdrive to produce more eggs now at the expense of the female’s long term survival.

It all sounds improbable and dystopian, but all of these mechanisms and more have been observed in that exceptionally promiscuous species, Drosophila. Drosophila seminal fluid has the property of reducing the female’s interest in remating, increasing her rate of egg-laying, and is also mildly toxic. Artificial selection in the lab can produce females that are resistant to the effects, and males that produce more and more potent semen to overcome their resistance, to the point where the line of “super potent” males, when crossed to unselected females, kill their partners with their ejaculations. There is literally a battle of the sexes in these species.

To speak up in my defense, though, not all males are evil exploitive pigs. The logic of this pattern of sexual competitiveness vanishes as species exhibit greater and greater monogamy—if you have only one mate, it is to your advantage to take good care of him or her, because a loss diminishes your reproductive fitness.

Rice WR (2000) Dangerous Liaisons. Proc. Nat. Acad. Sci. USA 97(24):12953-12955.

Rice WR (1996) Sexually antagonistic male adaptation triggered by experimental arrest of female evolution. Nature 381(6579):189-90.

I, for one, will welcome our Cyborg Insect overlords

Nah, I thought this has got to be a joke:

The Pentagon’s defence scientists want to create an army of cyber-insects that can be remotely controlled to check out explosives and send transmissions.

But no…there is actually a DARPA call for proposals.

DARPA seeks innovative proposals to develop technology to create insect-cyborgs, possibly enabled by intimately integrating microsystems within insects, during their early stages of metamorphoses. The healing processes from one metamorphic stage to the next stage are expected to yield more reliable bio-electromechanical interface to insects, as compared to adhesively bonded systems to adult insects. Once these platforms are integrated, various microsystem payloads can be mounted on the platforms with the goal of controlling insect locomotion, sense local environment, and scavenge power. Multidisciplinary teams of engineers, physicists, and biologists are expected to work together to develop new technologies utilizing insect biology, while developing foundations for the new field of insect cyborg engineering. The HI-MEMS may also serve as vehicles to conduct research to answer basic questions in biology.

The final demonstration goal of the HI-MEMS program is the delivery of an insect within five meters of a specific target located at hundred meters away, using electronic remote control, and/or global positioning system (GPS). Although flying insects are of great interest (e.g. moths and dragonflies), hopping and swimming insects could also meet final demonstration goals. In conjunction with delivery, the insect must remain stationary either indefinitely or until otherwise instructed. The insect-cyborg must also be able to transmit data from DOD relevant sensors, yielding information about the local environment. These sensors can include gas sensors, microphones, video, etc.

Although the idea of having a remote controlled dragonfly is very cool, I am very pessimistic, and have to dash a little cold water on the plan.

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