Dissecting embryos from half a billion years ago

i-7fe823a8a3ad74c60cac67b5ec0a8689-fossil_embryos_tease.jpg

There is a treasure trove in China: the well-preserved phosphatized embryos of the Doushantuo formation, a sampling of the developmental events in ancient metazoans between 551 and 635 million years ago. These are splendid specimens that give us a peek at some awesomely fragile organisms, and modern technology helps by giving us new tools, like x-ray computed tomography (CT), scanning electron microscopy (SEM), thin-section petrography, synchrotron X-ray tomographic microscopy (SRXTM), and computer-aided visualization, that allow us to dig into the fine detail inside these delicate specimens and display and manipulate the data. A new paper in Science describes a survey of a large collection of these embryos, probed with these new techniques, and rendered for our viewing pleasure…that is, we’ve got pretty pictures!

[Read more…]

Gogonasus andrewsae

Here’s another tetrapodomorph fish to consternate the creationists. These Devonian/Carboniferous animals just keep popping up to fill in the gaps in the evolutionary history of the tetrapod transition to the land—the last one was Tiktaalik.

i-8b2442cac1020896a08aca4650293aa3-gogonasus_skull_lat.jpg
Skull in lateral view.

This lovely beastie is more fish than frog, as you can tell—it was a marine fish, 384-380 million years old, from Australia, and it was beautifully preserved. Gogonasus is not a new species, but the extraction and analysis of a new specimen has caused its position in the evolutionary tree to be reevaluated.

[Read more…]

Hox complexity

Here’s a prediction for you: the image below is going to appear in a lot of textbooks in the near future.

i-9a6c4415bc9836c30f2c411c0936d212-septuple_hox.jpg
(click for larger image)

Confocal image of septuple in situ hybridization exhibiting the spatial expression of Hox gene transcripts in a developing Drosophila embryo. Stage 11 germband extended embryo (anterior to the left) is stained for labial (lab), Deformed (Dfd), Sex combs reduced (Scr), Antennapedia (Antp), Ultrabithorax (Ubx), abdominal-A (abd-A), Abdominal-B (Abd-B). Their orthologous relationships to vertebrate Hox homology groups are indicated below each gene.

That’s a technical tour-de-force: it’s a confocal image of a Drosophila embryo, stained with 7 fluorescent probes against different Hox genes. You can clearly see how they are laid out in order from the head end (at the left) to the tail end (which extends to the right, and then jackknifes over the top). Canonically, that order of expression along the body axis corresponds to the order of the genes in a cluster on the DNA, a property called colinearity. I’ve recently described work that shows that, in some organisms, colinearity breaks down. That colinearity seems to be a consequence of a primitive pattern of regulation that coupled the timing of development to the spatial arrangements of the tissues, and many organisms have evolved more sophisticated control of these patterning genes, making the old regulators obsolete…and allowing the clusters to break up without extreme consequences to the animal. A new review in Science by Lemons and McGinnis that surveys Hox gene clusters in different lineages shows that the control of the Hox genes is much, much more complicated than previously thought.

[Read more…]