Losers

I am encouraged by the defeat of Victor Orban in Hungary. I’m happy for the people of Hungary throwing off the yoke of fascism and having hope for the future, and for the people of Europe as a whole building a stronger alliance.

But I’m selfish. I’m also happy to see JD Vance flop hard; it was unbelievable to me that Republicans from America were campaigning for Orban. Vance was politicking for Orban just recently, as part of his personal campaign to appear ‘presidential,’ and many right-wingers have been on the Orban train for a long, long time. The Hungarian election was a harbinger of the American elections to come, and the message is clear: Vance is a loser. Republicans are losers. Trump is a loser. They should be nervous, because they’re all just waiting for the axe to fall.

Down, down, in the dark

Shirtsleeve weather, the sun is shining bright, and there are stirrings in the darkness. I prowled about my yard, searching for spiders, but the best I could find was spider-sign — they’re out and about, leaving strands of silk in crevices and corners, but I saw none.

That is, until I turned to the ever-reliable compost bin. I found even more silk everywhere in there, but to find an inhabitant I had to bend over and stick my head upside down deep into the bin, way down low until I was look just above the edge of the decaying plants, and there at last I found one, a familiar old friend, Steatoda borealis.

S. borealis is entirely black in body color, and she was on the side of a black bin, in shadow, deep in darkness, so getting any kind of photo was difficult. But there she was, my first Theridiidae of the new season.

This compost bin is a favored spot. I think they snuggle down in the layers of rotting glop and overwinter there, and then they’re the first to reappear once the weather well and truly breaks. It’s kind of sweet to think of them sleeping down in the dark, in the mulch, all winter long, waiting to reemerge.

I’ve got homework for you

OK, gang, help me out here. I’m swamped today — my morning is destroyed because I have to go in to the clinic for my annual thorough extensive physical check-up, and I get out just in time for my afternoon class, and then I’m free, sort of. Except that I have to compose a 10 question online quiz on chromosome variations.

So give me some good questions on deletions, duplications, inversions, and translocations. Preferably questions that can be easily machine-scored, but I do throw in an essay question or two.

Get to work. I’ll expect them in the comments section here when I get back at 1:30.

Don’t disappoint me.

Genetics progress

Today was a lab day, and I’m happy to report that the students have achieved perfection. Every fly bottle was beautiful, full of maggots and pupae, and not one hint of contamination among them all. And so many pupae already! This is excellent news, because next week swarms of adult F2 flies will emerge and the students will have to score and count them all to finish this mapping cross.

Score. And count. ALL. Next week’s lab will require extra time to complete, and I let them know that today. It’s been typical to count 10-15,000 flies in the final cross in this class, but I don’t expect that many this year (it’s a small class of only 8 students*), and I don’t grade them on raw numbers but on how well they analyze and interpret the numbers they do get. I think this experiment will be ending on a high note, at least, and the maggoty-side will be over next week, leaving them two weeks to put together a lab report.

I also committed the students to a specific in-class presentations on the 27th of April, the last week of class. We really are winding down.

*8 is an unusually low number of students — we hit a trough in enrollment numbers a few years ago. I wouldn’t mind classes this small every year, but I suppose we need a larger enrollment to sustain the university. I see good signs for the future**: my cell biology course in the Fall is nearly full, and registration isn’t quite over yet.

**I would like to have my final year here, the 2026-2027 academic year, be a bountiful year. I’d like to exit with a good term.

Not funny

I did not like this Far Side cartoon for obvious reasons.

This could do real harm, burning the victim’s neck, and if I caught anyone doing this they would be immediately expelled from the lab. Not funny.

Additionally, I have a personal memory of my first year in general chemistry. I had a lab partner who was a total klutz — I carried her through that lab, in spite of her inability to titrate anything. She was a danger with a pipette, and every week I’d go back to the dorm to discover that somehow the back of my pants and shirt had been spattered with acids — when I’d do my laundry I’d discover all these holes in my clothes, which was also not funny.

I’ve wondered for years if my lab partner really disliked me, or if she was trying to get my attention because she liked me, or she was just ridiculously incompetent in the lab. It happened so often that I suspect the first possibility.

The dumb ones keep coming back

Some of you may recall a particularly obnoxious commenter who called himself Jinx McHue, among other names — he was one of those who made stupid comments, got banned, and then tried to make multiple appearances under different pseudonyms, and got banned for each one. I guess he’s still reading, because he tried to comment again, but he got blocked, as usual. But maybe you’d be entertained by his attempt?

So, you’re mad when he threatens to nuke Iran, but then you turn around and are mad when he doesn’t. You people are dumber than he is.

He doesn’t get it. Yes, we’re mad that he threatened to nuke Iran, because that would be evil and criminal. No, we’re not mad that he didn’t nuke Iran. We’re mad that he’s trying to implement international diplomacy by making evil, criminal threats and bragging about maybe doing war crimes.

I wonder…was he happy when he made the threat, or happy when he didn’t follow through?

Life from space? I have questions

Samples have been analyzed from two carbonaceous chondrites in space, Ryugu and Bennu, and they’ve been found to contain common organic molecules, specifically, the building blocks of DNA. That’s cool, not particularly surprising, and it’s good stuff to know…but then we get all these pop science articles speculating that life came from space. No, no, no — it tells us that these organic molecules are universal, that they can be assembled by all kinds of physical/chemical processes, and that nucleotides (for instance) do not require synthesis by living organisms. Chemistry is everywhere, but biology isn’t. Unfortunately, these kinds of observations always provoke people to babble about life, or at least the ingredients for life, falling from space. I don’t buy it.

Scientists have discovered all five nucleobases—the fundamental components of DNA and RNA—in pristine samples from the asteroid Ryugu, according to a study published on Monday in Nature Astronomy. The finding strengthens the case that the ingredients for life are abundant in the solar system and may have found their way to Earth from space, according to a study published on Monday in Nature Astronomy.

OK, yes, it’s quite likely that some organic molecules fell to Earth from outer space. But please, think a little bit quantitatively. There are clouds of organic molecules in space, but they are incredibly diffuse and poorly concentrated. There are asteroids that are made of condensed lumps of carbon with richer concentrations of these molecules, but they are drifting in the vast empty volumes of space, and only occasionally falling to Earth, adding droplets of nucleotides to the Earth’s oceans.

Meanwhile, the Earth itself is a gigantic crucible containing 1,386,000,000 cubic kilometers of water, with a complex pattern of heating and cooling, and immeasurable interactions with minerals and other organic molecules. It is a far weightier contributor to biochemistry than a thin, almost undetectable, vapor of scattered molecules in space. But these stories always get excited about the thin vapor rather than the fact that Earth itself is a rich churning cauldron of geochemistry that is going to be far more responsible for the wealth of biologically relevant chemistry we find ourselves swimming in.

This is not to discount how interesting these asteroid analyses are. They’re telling us that natural, unguided mechanisms can produce the biomolecules that make up life. The asteroids, though, are not likely to be where they originated here, on planet Earth, which is already a great place for building them.

The article says something else that irritated me.

Now, following the discovery of all five nucleobases in the Bennu pebbles, Koga and his colleagues have found the complete set in Ryugu. The findings lend weight to the so-called “RNA world” model of abiogenesis. In this hypothesis, early life on Earth depended solely on RNA as a self-replicating molecule, laying the biological groundwork for later, more complicated systems that involved DNA and protein-based organisms. The extraterrestrial samples from Ryugu and Bennu provide evidence that at least some of the nucleobases that made up these early lifeforms came from outer space.

No, this observation says nothing relevant to the RNA World hypothesis. It neither confirms nor refutes it. Nucleobases exist, we’ve known that for a long, long time, but I don’t believe that the earliest life on Earth depended solely on RNA, and finding nucleobases in a lifeless rock is not evidence that life was solely spawned from those few components. Were there no other molecules in them? No sugars, no amino acids, no polycyclic aromatic hydrocarbons, no carboxylic acids? There are a great many complex organic molecules found bubbling in the soup of our oceans, aren’t they a more likely source of life than a dead lump that’s been floating in space for billions of years?

Sorry. It’s a good bit of science, but I get cranky when I read these ill-informed unwarranted speculations that ignore more substantial science.

He always chickens out. Good.

Trump talked to some Pakistani leaders, and that was good enough. He has announced a ceasefire.

President Donald Trump said he’d agreed to a two-week ceasefire with Iran on Tuesday, less than two hours before his 8 p.m. deadline to destroy a “whole civilization.”

Trump said the ceasefire agreement was made on the condition that Iran agree to reopen the critical Strait of Hormuz.

Based on conversations with Prime Minister Shehbaz Sharif and Field Marshal Asim Munir, of Pakistan, and wherein they requested that I hold off the destructive force being sent tonight to Iran, and subject to the Islamic Republic of Iran agreeing to the COMPLETE, IMMEDIATE, and SAFE OPENING of the Strait of Hormuz, I agree to suspend the bombing and attack of Iran for a period of two weeks. This will be a double sided CEASEFIRE!, Trump posted on Truth Social.

The reason for doing so is that we have already met and exceeded all Military objectives, and are very far along with a definitive Agreement concerning Longterm PEACE with Iran, and PEACE in the Middle East, Trump wrote.

See? He thinks he won already. Iran said nothing.

How about if we just ignore him from now on and focus on the Epstein files and getting him out of office?

I’ve had few opportunities to photograph spiders

I haven’t been showing off my spiders much lately. There’s a reason for that. They still think it’s winter, so they’re all hunkered down in their mossy, silk-covered nests, and they don’t come out much, and when they do, they’re shy and not very photogenic. Here’s the best black widow shot I could get today.

I didn’t do myself any favors by providing them with a fairly cluttered environment, but they seem to like a space where they can hide and only come out to grab some food, and then retire quickly back into their refuge. They’re very retiring little ladies.

Minnesota is warming up, though. The snow is mostly gone, and I occasionally see jumping spiders sunning themselves, so I’m hoping to go hunting native spiders again soon.

He’s absolutely, utterly insane, and a danger to the world

I hope TACO Trump chickens out by 7pm Central time, but right now he’s blustering and posturing even more than usual.

A whole civilization will die tonight, never to be brought back again. | don’t want that to happen, but it probably will. However, now that we have Complete and Total Regime Change, where different, smarter, and less radicalized minds prevail, maybe something revolutionarily wonderful can happen, WHO KNOWS? We will find out tonight, one of the most important moments in the long and complex history of the World. 47 years of extortion, corruption, and death, will finally end. God Bless the Great People of Iran!

Right. God bless the people of Iran while threatening to obliterate them. He’s either steeling his nerve to pull the trigger on an action that will make him even more of a criminal in the eyes of the civilized world, or he’s hoping for something revolutionarily wonderful to act as a pretext to back off. I don’t think he’s going to get one. Iran despises him, and by association, the rest of the United States, so I suspect they’re going to do nothing, in expectation that he’ll waste another few billion dollars in futile destruction.

I don’t know what will happen tonight, but one thing I do know: Iranian civilization will still exist tomorrow, and Trump will look like an impotent, hateful fool.