Stem cell soundbite

While browsing through the UW Alumni magazine (yes, I read it; no, please don’t ask me for money, I’m poor), I ran across a nice quote I thought I’d share:

Imagine it like the software in a computer that is five years old…these [stem] cell lines are inherently inferior. We’re forced to focus our efforts on lines that are inherently less innovative.

Dr Anthony Blau, commenting on Bush’s veto of a bill that would open up new cell lines for research

Needs more arrows

But I like it anyway. It’s a series of charts illustrating channels of communication of science.

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I appreciate the distinction made between “Average Citizen” and “Informed Citizen.” Maybe there ought to be another box interposed between “Mainstream Media” and “The Average Citizen” labeled “Fox News/Talk Radio/Other Organs of Propaganda,” though. And shouldn’t there be another arrow from “Mainstream Media” to “Informed Citizen”?

Developmental Biology 4181: Week 1

I’m teaching a course in developmental biology this term, and as part of the coursework, I’m making students blog. The idea is to force them to ferret out instances of development in popular culture, in their personal experience, and/or in their reading—I’m not asking for treatises, but simply short articles that let me know their eyes are open. This year I’m also encouraging outsiders to take a look at and comment on what they’re saying, so every week I’ll be posting a round-up of links to the developmental biology blog…and here they are:

Feel free to comment on any of them if the mood strikes you, but I am going to be particularly protective of my students, so I insist on only constructive comments. I will ruthlessly delete anything abusive or irrelevant or otherwise distracting.

One other thing we’re doing in the class is working through Carroll’s Endless Forms Most Beautiful, and before each discussion I ask the students to write up short summaries of the reading. Tomorrow, we’re going over chapter 1 and 2, and there are six different summaries up on the site right now:

A,
B,
C,
D,
E, and
F (no, those are most definitely not the grades!). I’ll usually have these things linked up a little earlier before the class, but I gave the students extra slack this time since it was a holiday week. Comments and questions there are also appreciated—if there’s something you think the students ought to bring up in the discussion, let ’em know!

Write letters!

One after the other, I got two requests to promote some worthy causes which need letter-writers to help out. Here they are:

Save wilderness:

Over the strong objections of Native people, wildlife biologists, sportsmen’s groups, and the general public, the Bureau of Land Management remains intent on leasing one of the most remarkable wetlands complexes on the planet. The place is the Teshekpuk Lake Special Area in the National Petroleum Reserve-Alaska (NPR-A), the largest single block of wild public land left in the United States.


Save minds:

On Monday, the Ohio Board of Education will hold its first fall meeting. Creationists on the board are hoping to introduce a Controversial Issues Template, which would not only allow for the teaching of intelligent design in science classrooms, but demand that teachers question global warming and highlight the religious right’s opposition to stem cell research.


Don’t just sit there! Do something!

Save the Gay Sheep!

Since we biologists were just bizarrely accused of being like a bunch of animal rights activists, I am surprised that when I read that PETA opposes experiments on gay sheep, I find myself opposing PETA and thinking that the experiments sound cool and interesting and informative. I’m also a little disgusted with the way PETA finds it necessary to lie in their criticisms.

The Next Hurrah has a thorough take-down of PETA. Particularly amusing is the statistic that the research involves 18 sheep a year, while meat-packers butcher 4 million per year…so which one do the kooky extremists of the animal rights movement go after? There is an entirely appropriate quote from Mark Twain that applies here: “To create man was a fine and original idea; but to add the sheep was a tautology.” Research that studies cute little lambs and can be tied to homosexual shibboleths of both the right and the left sounds like the perfect scapegoat to lead more people to contribute to their cause; damning lamb chops and mutton just doesn’t push the right buttons.

MnCSE!

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Good news for Minnesota! Minnesota Citizens for Science Education has been officially launched. This is a new advocacy group with the goal of promoting good science education in our state. Specifically—

A scientifically literate population is essential to Minnesota’s future. To that end, Minnesota Citizens for Science Education (MnCSE) will bring together the combined resources of teachers, scientists, and citizens to assure, defend, and promote the teaching and learning of evolutionary biology and other sciences in K-12 public school science classrooms, consistent with current scientific knowledge, theories, and practice.

If you’d like to be more involved, join the group. Browse the personal statements of the science advisors. Come on down to Science Education Saturday at the Bell Museum, on 11 November.

Oh, and if you like the logo, buy it on a t-shirt or coffee mug.

Dobzhansky on eugenics

John Wilkins is fighting the philosophical and historical fight against the Darwin’s Deadly Legacy nonsense with an excellent summary of the course of the eugenics movement. I especially liked this quote from Dobzhansky:

The eugenical Jeremiahs keep constantly before our eyes the nightmare of human populations accumulating recessive genes that produce pathological effects when homozygous. These prophets of doom seem to be unaware of the fact that wild species in the state of nature fare in this respect no better than man does with all the artificiality of his surroundings, and yet life has not come to an end on this planet. The eschatological cries proclaiming the failure of natural selection to operate in human populations have more to do with political beliefs than with scientific findings.

If you don’t know who Theodosius Dobzhansky was, he was one of the founders of the neo-Darwinian synthesis, and was far, far more influential on evolutionary thinking than either Haeckel or Hitler. Scientific leaders were calling this stuff nonsense before Hitler tried to invoke his Final Solution.

Molecular machines!

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If you’ve ever wondered what the heck Behe was smoking when he claims there are literal trucks trundling about on literal highways with literal traffic signals inside of cells, well, I don’t have an answer for you…but there is a wonderful Flash movie that will show you the Inner Life of a Cell so you can see what “molecular machines” look like, more or less. It’s a spectacular show. What you’ll see is the series of events that transpire when a lymphocyte encounters a cell surface signal that triggers emigration out of a capillary and into other tissues; it zooms rather abruptly from a cellular view to the molecules on the surface interacting with one another, then into the interior of the cell to see the response. All kinds of cool stuff fly by: actin and microtubule assembly and disassembly, kinesin-mediated vesicle transport, protein synthesis on ribosomes, ER processing, vesicle fusion, etc.

I do have a couple of gripes, though. One is an understandable shortcut: the cell is far too uncluttered, and events proceed in too directed a manner—there ought to be much more stochastic noise at the molecular level. We’re seeing chemistry in action, after all. Another is that there is no explanation at all for anything we’re seeing, it’s simply a weird and trippy voyage into a subcellular world. This clip was created under the auspices of Harvard scientists, so I hope there is a viewing guide somewhere, otherwise it’s only going to be appreciated by people who have already read Molecular Biology of the Cell(amzn/b&n/abe/pwll). I think it also needed a disclaimer somewhere that this video too is a visual metaphor for cellular activity.

But I’m being picky. Otherwise, it’s an excellent introduction to the profound weirdness of the processes going on inside a cell.

And really, Buffy’s biology is wonderful!

Physicists get all the fun. Jennifer Ouellette has announced a book I’ll definitely be buying: The Physics of the Buffyverse(amzn/b&n/abe/pwll). How could I not? It will go on the shelf next to my copy of The Physics of Superheroes(amzn/b&n/abe/pwll).

So, where’s The Biology of Superheroes? The creators of superheroes trample all over the principles of physiology and genetics as thoroughly as they do those of physics, so there’s got to be a story in there somewhere.