You are a mutant, and your genome is full of junk. What’s the problem?

These kinds of calculations are always handy. Larry Moran estimates the number of novel mutations you carry: the textbooks say about 300, he calculates something over 120. So next time a creationist tells you all mutations are deleterious, just tell him he’s a mutant himself with somewhere around a few hundred random nucleotide changes from either of his parents. What Larry doesn’t mention in this estimate, but I know he’s familiar with the idea, is that most of those mutations will be neutral: about 95% will fall into junk DNA, many won’t affect the amino acid sequence of any proteins, others may cause slight changes in the protein sequence that don’t detectably affect the phenotype.

In the category of utterly baffling pronouncements from scientists, Larry also chastises John Greally for misrepresenting junk DNA in an interview with Ira Flatow. I could scarcely believe it myself, but I listened to the interview, and Greally actually seems to be conflating regulatory sequences with junk, and Flatow introduces the story as suggesting that junk DNA may all have a function. He also claims that if you have a mutation in a gene, the “gene is dead” and will have no function. None of this is correct. It’s bizarre—I think Larry and I are fairly familiar with the genetics literature, and there’s nothing to support these contentions and quite a bit to contradict them.

It’s good to be home, especially when welcomed by Natalie Angier

I’m home from our vacation, and our painfully tiring redeye flight from Seattle, and I get a treat right as I step through the door: a copy of Natalie Angier’s The Canon(amzn/b&n/abe/pwll) arrived in the mail while I was away. What did I do? Right after we got all the luggage into the house, I flopped down on the bed with it and read it until the lack of sleep caught up with me — and it’s good enough that I actually made it through the first two chapters before passing out. It’s a passionate and enthusiastic survey of basic principles in science, and it’s fun to read.

Then I discovered that onegoodmove had a video interview of Angier talking about her book. She’s very good; check it out. She’s the kind of science journalist I want to see more of, and everyone should go out and buy her book to encourage her to do more.

One annoyance: several of the commenters at onegoodmove seem to be of the concern troll variety. Here’s this smart, fluent, talented writer who is also a world-class science geek and atheist, and they start picking over her appearance and body language — it’s rather dismaying, in particular since her gestures are no more flamboyant than those of her (male) interviewer. I’ve long thought that Natalie Angier would make an excellent spokesperson for godless science, and wondered why we don’t see more of her … and I wonder if part of the reason is that the same troglodytes who grunt in disgust at the sight of someone who doesn’t respect their sky-god are also appalled at the sight of a woman speaking confidently about high geek factor subjects and also dismissing their primitive superstitions.

Now this is how to critique Ken Ham’s creation “museum”

This video is one of the most effective criticisms of Ham’s horrible little monument to ignorance in Kentucky — it’s a geological tour of the rocks the “museum” is built upon. It seems the creationists chose to build on some beautifully fossil-rich Ordovician layers.

It convinces me that if I were in the Cincinnati area I’d rather kick around in the hills around the area than to waste my time in a pile of bunk.

Here’s a useful datum to settle arguments with your spouse

Who’s chattier, men or women? This is a simple study that strapped microphones onto subjects that turned on for 30 seconds every 12.5 minutes so that the investigators could do word counts. Here’s the final tally of the average number of words spoken per day:

Men: 15,669 ± 8343

Women: 16,215 ± 7301

There’s no significant difference between the two.

Mehl MR, Vazire S, Ramírez-Esparza N, Slatcher RB, Pennebaker JW (2007) Are Women Really More Talkative Than Men? Science 317:82.

Microblogology

Hey, if you’ve been wondering what the sex symbols of science blogging look like, here’s your chance: a video of some bloggin’ microbiologists hanging out in Toronto.

Although, that title … it’s hard to imagine an uglier word than “blog,” but they managed to coin one.

We don’t have physics envy, but we still have to deal with physics snobbery

Peggy has an excellent discusion of the peculiar attitudes towards biology held by physicists and engineers, which includes this wonderful complaint by Jack Cohen:

In summer 2002, I was at the Cheltenham Festival of Science. Lots of biologists presenting, for sure. But… one very popular event was a presentation by three famous astronomers: ‘Is There Life Out There?’ I prefaced my first question to them by a little imaginative scenario: three biologists discussing the properties of the black hole in the middle of our galaxy. It was very clear that the astronomers really believed that they could discuss ‘life’ professionally, whereas everyone saw biologists talking about black holes as absurd.

Oh, and let’s get started on how SF treats biology…

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New York Times gives evolution a day

The NY Times has pulled out all the stops today and has dedicated their entire science section to the subject of evolution. They’ve got pieces by some of the best science journalists around, like Carl Zimmer, Cornelia Dean (although in this case, it’s a lot of nattering on about how the soul fits into evolution—not recommended), and Natalie Angier, and they’ve also drafted a few scientists. There’s a video of Sean Carroll summarizing evo-devo, and perhaps the most interesting article of them all is by Douglas Erwin, in which he speculates about whether the new ideas percolating throughout the science community (especially by those noisy developmental biologists) are precursors to a new revolution in our thinking about evolution. He’s non-committal so far, which is fair.

Does all this add up to a new modern synthesis? There is certainly no consensus among evolutionary biologists, but development, ecology, genetics and paleontology all provide new perspectives on how evolution operates, and how we should study it. None of these concerns provide a scintilla of hope for creationists, as scientific investigations are already providing new insights into these issues. The foundations for a paradigm shift may be in place, but it may be some time before we see whether a truly novel perspective develops or these tensions are accommodated within an expanded modern synthesis.

Or both! I expect that what will happen is that the deficiencies in the neo-Darwinian synthesis (which lacks any explanation for the evolution of form and pattern, for instance) will be gradually filled in with clear linkages to the evolution of genes, and despite the fact that it will be a bigger, bolder, stronger synthesis, everyone will say we knew it all along anyway. There will not be a threshold moment where everyone says “Wow! I am suddenly enlightened!” — there will just come a time when everyone acknowledges that all those papers from 40 years ago were pretty darned important, after all.

Mohler fears the cookie-eating mouse

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The operation was a success. Later, the duck, with his new human brain, went on to become the leader of a great flock. Irwin, however, was ostracized by his friends and family and eventually just wandered south.

Dr. R. Albert Mohler, Jr., president of The Southern Baptist Theological Seminary, is worried. He’s afraid we’re going to put a human brain in a rodent’s head. No, really — it’s not just a joke in a cartoon. He seriously wants to suppress research in transgenic and chimeric animals “before a mouse really does come up and ask for a cookie.” Now, seriously, his worry isn’t that mice will be smarter than he is and eat all his cookies. No, he has better reasons.

The scariest part of this research is directed at work done in hope of curing or treating diseases of the human brain.

They might cure debilitating neurological diseases like Alzheimer’s or cerebral palsy or schizophrenia! Those horrible, horrible scientists—how dare they cure our god-given afflictions. We deserve them!

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Pair-rule genes

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The general pattern of developing positional information in Drosophila starts out relatively simply and gets increasingly complicated as time goes by. Initially, there is a very broad distribution of a gradient of a maternal morphogen. That morphogen then triggers the expression of narrower (but still fairly broad) bands of aperiodic gap genes. The next step in this process is to turn on sets of genes in narrow, periodic bands that correspond to body segments. This next set of genes are called the pair-rule genes, because they do something surprising and rather neat: they are turned on in precisely alternating bands. In the picture above, for instance, one pair-rule gene, even-skipped, has been stained blue, and it is expressed in parasegment* 1, 3, 5, 7, etc. Another, fushi tarazu, has been stained brown, and this gene is turned on in parasegments 2, 4, 6, 8, etc.

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Change is coming, you might as well embrace it

Mark Morford is wonderfully excited about the prospects for biological research, and I don’t blame him. Consider what the world was like in 1900 and how physics and engineering changed it by 2000; from horse-and-buggy and steam locomotive to interstates and jet planes, from telegraph to world-wide communication networks. We’re going to see a revolution of that magnitude in the coming century, too, and you can expect biology and medicine to be at the forefront. Well, maybe. As Morford writes, the alternative is to

…hold tight to the leaky life raft of inflexible ideology (hello, organized religion), to rules and laws and codes of conduct written by the fearful, for the fearful, to live in constant low-level dread of all the extraordinary changes and radical rethinkings of what it means to be human or animal or male or female or hetero or homo or any other swell little label you thought was solid and trustworthy but which is increasingly proven to be blurry and unpredictable and just a little dangerous.

We know which side GW Bush and the Republican party are on: with the knuckle-draggers and antique hierarchies of organized religion. Our president has vetoed a bill to support stem cell research. This is remarkable: he has only vetoed three bills in his entire presidency, and two of them have been with the intent of killing stem cell research. Just as remarkably, our representatives in congress haven’t been able to muster the numbers to override that veto. Imagine if the American government had voted to censure the Wright brothers and to outlaw the internal combustion engine at the turn of the last century, or if they’d decided to condemn the kinds of radical and dangerous physics being pursued at places like Princeton and Chicago. It wouldn’t have changed a thing about the natural world, or the discoveries that were made; it might have slowed the pace a bit, but the changes would still have come from England and France and Germany and Japan and the Soviet Union … the biggest difference would be that the United States would be an irrelevant backwater.

That’s what the Republicans are doing to this country right now: damning us to a future as a backward, corrupt mess, a big, blundering headache for the world. In 2100, will the rest of the planet see us in the same way Turkey was seen in 1900?