I mean, really, the Republicans hate evolution so much they’ll kill everyone out of spite

If you’re looking for some fun summer beach reading, I can’t recommend this article, The origins and potential future of SARS-CoV-2 variants of concern in the evolving COVID-19 pandemic. It’s a summary of the past year of the pandemic.

One year into the global COVID-19 pandemic, the focus of attention has shifted to the emergence and spread of SARS-CoV-2 variants of concern (VOCs). After nearly a year of the pandemic with little evolutionary change affecting human health, several variants have now been shown to have substantial detrimental effects on transmission and severity of the virus. Public health officials, medical practitioners, scientists, and the broader community have since been scrambling to understand what these variants mean for diagnosis, treatment, and the control of the pandemic through nonpharmaceutical interventions and vaccines. Here we explore the evolutionary processes that are involved in the emergence of new variants, what we can expect in terms of the future emergence of VOCs, and what we can do to minimise their impact.

Oh, right, I really don’t want to hear about how “several variants have now been shown to have substantial detrimental effects on transmission and severity of the virus”, but they do, and it’s a worry. Here, for example:

So the reassuring (and unsurprising) fact is that the virus isn’t really being selected directly for lethality. Doesn’t that make you feel better? All the virus ‘cares’ about is increasing the number of viruses, of increasing the viral load, and it could do that by having milder effects on their host. The B.1.1.7 variant isn’t doing that. It is increasing the load in your cells with no ameliorating mutations, and so is having more severe effects.

In case you were wondering, B.1.1.7 is going by the common name of the Alpha variant. It’s not nice. At the end of that excerpt, it says a bit about the B.1.167.2 variant, which is even nastier, with 64% greater transmissibility. You probably know it better as the Delta variant, which is now the dominant strain in the US.

You know there are also Beta, Kappa, Theta, and Zeta variants, right? I can’t keep track of them all. I guarantee that more will be arising. Isn’t evolution amazing? If only we lived in a country where the power of evolution was appreciated.

The article tries to be encouraging in its conclusion.

As COVID-19 transitions from a pandemic to an endemic disease, VOCs present new global challenges to health by virtue of increased transmissibility and virulence and evasion of natural and vaccine-induced immunity. In this article we have explored the selective forces that shape how VOCs emerge and become established. We also identify possible steps that we can take to limit their emergence and, when they do arise, their impact. Moving forward, we must also consider how SARS-CoV-2 transmits to and amongst other animal species, placing both them and us at further risk. It will therefore be important to adopt a multidisciplinary One Health approach for future pandemic management that accounts for the interrelated nature of human, animal, and ecosystem health.

Oh, good, steps to limit the emergence and impact of variants…[quickly flips back a few pages to see what those are].

More broadly, we can reduce the rate of emergence of new VOCs and slow the spread of existing ones by reducing overall case numbers through vaccination at a global scale and by maintaining or enhancing the non-pharmaceutical interventions that have contributed to controlling the pandemic (case detection and isolation, contact tracing and quarantine, masking and personal distancing, and improved ventilation). Having low case numbers makes it easier to test and genotype a high fraction of cases and increases the efficacy of contact tracing measures to stop onward transmission. Furthermore, mathematical models predict that measures that reduce contact rates with susceptible individuals will not only slow the spread of SARS-CoV-2 overall but will also reduce the relative advantage of variants that have a transmission advantage. Thus, the measures taken to reduce contacts and limit the number of COVID-19 cases may have the added benefit of slowing the rate at which VOCs with a transmission advantage overtake the wildtype. This predicted pattern, with selection weakening as stringency measures are increased, appears to be borne out in data for B.1.1.7 from England and British Columbia.

So, all we need to do is vaccinate everyone, keep wearing masks and maintain social distancing…how is that working out for you, America? It’s basic stuff, it’s all within our reach, but it’s Republican policy to deny every one of those actions. Keep it in mind that their policies aren’t just killing their constituents, they’re also increasing the likelihood of new variants that will harm non-Republicans, even in Democratic states, and even in foreign countries that want nothing to do with our contemptible politics.

To be fair, I shouldn’t blame only Republicans. My university is opening up in the fall with no vaccination requirement, and is debating reducing the social distancing requirement.

Oh no. Richard Lewontin has died

This is terrible news. He was so influential on my thinking about biology, personally.

If I had my way, one of his books would be required reading in our introductory biology course (we decide on books as a group, so no, I’m not in charge). My only problem would be picking which one?

Fortunately, I do have total control over your reading habits (I don’t want to know if that’s not true), so I shall command you all to run out and buy and read all of these to do honor to the man.

OK, if you are resisting my influence, pick at least one. The first two are slim books, short and easy; if I were to foist any book on my students it would probably be The Triple Helix. They’re all good, and they all represent a perspective that our society needs right now.

It’s like reading the letters section of my local newspaper!

Small town newspapers occasionally get letter-feuds going — it fuels subscriptions, since you really want to know how angry Sally Jo is going to get with Fred over his dog tearing up her petunias, and the back and forth can go on for months. Sometimes science gets that way, too.

The backstory: Augustin Fuentes wrote an editorial for Science in which he pointed out that Charles Darwin was a flawed, prejudiced Victorian man, as part of a celebration of the 150th anniversary of the publication of the Descent of Man. While he may have been somewhat more progressive than many of his contemporaries, he still had awful racist views.

Darwin portrayed Indigenous peoples of the Americas and Australia as less than Europeans in capacity and behavior. Peoples of the African continent were consistently referred to as cognitively depauperate, less capable, and of a lower rank than other races. These assertions are confounding because in “Descent” Darwin offered refutation of natural selection as the process differentiating races, noting that traits used to characterize them appeared nonfunctional relative to capacity for success. As a scientist this should have given him pause, yet he still, baselessly, asserted evolutionary differences between races. He went beyond simple racial rankings, offering justification of empire and colonialism, and genocide, through “survival of the fittest.” This too is confounding given Darwin’s robust stance against slavery.

Not to mention his ideas about women.

In “Descent,” Darwin identified women as less capable than (White) men, often akin to the “lower races.” He described man as more courageous, energetic, inventive, and intelligent, invoking natural and sexual selection as justification, despite the lack of concrete data and biological assessment. His adamant assertions about the centrality of male agency and the passivity of the female in evolutionary processes, for humans and across the animal world, resonate with both Victorian and contemporary misogyny.

“GASP!” went some scientists. How dare he be so rude? Think of the harm it will do to science education if we reveal the flaws in our heroes! So they fired off a letter to the editor.

We fear that Fuentes’ vituperative exposition will encourage a spectrum of anti-evolution voices and damage prospects for an expanded, more gender and ethnically diverse new generation of evolutionary scientists.

Oh, dear. So rather than be interested in the truth, we should conceal those past embarrassments, lest a creationist discover them. This is a terrible idea, because eventually someone will discover them (they’re in books in the public domain, you know), and then it’ll be the cover-up that is the scandal. Have they learned nothing from political history?

In The Descent he demolished the slavery-justifying view of different races as separate species, so inspiring the anti-racist perspectives of later anthropologists like Boaz. On sexism, Darwin suggested that education of “reason and imagination” would erase mental sex differences. His theory of sexual selection gave female animals a central role in mate choice and evolution.

On races, sure, he was better than many, and he also criticizes the race “science” of his day, noting that none of the proponents of that dangerous nonsense could even agree on the number and boundaries of the various races. He was an abolitionist, but as we Americans should know from our history, you can oppose slavery while still having demeaning views of black people. While it is correct that he demolished the idea of different races as different species, he still thought the races had different characters, which is a belief that still feeds racist views. Like this, from the Descent of Man.

There is, however, no doubt that the various races, when carefully compared and measured, differ much from each other,—as in the texture of the hair, the relative proportions of all parts of the body, the capacity of the lungs, the form and capacity of the skull, and even in the convolutions of the brain. But it would be an endless task to specify the numerous points of structural difference. The races differ also in constitution, in acclimatisation, and in liability to certain diseases. Their mental characteristics are likewise very distinct; chiefly as it would appear in their emotional, but partly in their intellectual, faculties. Every one who has had the opportunity of comparison, must have been struck with the contrast between the taciturn, even morose, aborigines of S. America and the light-hearted, talkative negroes.

Oh, those light-hearted negroes, chattering away happily out on the plantation, with their distinct mental characteristics! How dare you accuse Darwin of still clinging to the stereotypes of his day, and being less enlightened than he should have been?

What about his views on women? Did Darwin really think the differences in intellect between men and women would be erased by education?

Here my comparison to conflicts in the letters section of my local newspaper falls down, because Science hasn’t published what should be the next reply in the chain. Holly Dunsworth called the Darwin apologists on their claims by actually reading their citation that purportedly shows how egalitarian Darwin was. Ooops. Here’s Dunsworth’s letter in full:

Whiten et al. described Fuentes’ editorial as a “distorting treatment” of Darwin’s writing in Descent of Man.

As counterpoint to Fuentes’ points about Darwin’s racism and sexism, Whiten et al. wrote that,

On sexism, Darwin suggested that education of “reason and imagination” would erase mental sex differences (1, p. 329).

From that sentence, a reader might reason that Darwin wrote about how educating women could make them equal to men in mental powers. And, a reader might imagine that Darwin advocated for such a thing.

Darwin did neither in the cited passage which says,

In order that woman should reach the same standard as man, she ought, when nearly adult, to be trained to energy and perseverance, and to have her reason and imagination exercised to the highest point; and then she would probably transmit these qualities chiefly to her adult daughters. The whole body of women, however, could not be thus raised, unless during many generations the women who excelled in the above robust virtues were married, and produced offspring in larger numbers than other women. As before remarked with respect to bodily strength, although men do not now fight for the sake of obtaining wives, and this form of selection has passed away, yet they generally have to undergo, during manhood, a severe struggle in order to maintain themselves and their families; and this will tend to keep up or even increase their mental powers, and, as a consequence, the present inequality between the sexes. (1, p. 329)

There is no hope for women and, by the end, Darwin is back on about how men are superior and suggests that they may evolve to be even more so.

It took extraordinary imagination to read that passage from Descent of Man and present it casually in Darwin’s defense as Whiten et al. did.

Now that’s a distorting treatment.

Wow. That passage could be happily quoted by MRAs, anti-feminists, and the general mob of misogynists as perfectly compatible with their views. Do not get into a sparring match with Dr Dunsworth, she’ll cut you.

One other curious thing about that passage…Darwin at the time he wrote Descent of Man was, unfortunately, lacking in a good theory of inheritance and had stumbled into pangenesis — he was basically a Lamarckian. That’s what that bit about how an adult woman had to be trained to “energy and perseverance” so that she would similarly train her daughters, who over many generations might rise to be as smart as a man, if such clever daughters might succeed in producing as many children as those other silly, flighty women. It’s not only profoundly sexist, it’s bad evolutionary logic! He’s not touting the equality of women at all — he’s simply promoting his wrong ideas about the inheritance of acquired characters.

(I’ve written about this before, so this is old ground. Darwin had some even more blatantly sexist passages in the Descent of Man. What’s really going to “encourage a spectrum of anti-evolution voices” is this embarrassing idolatry.)

That’s definitely not a spider

At least, I’m pretty sure.

That’s Homo longi, or Dragon Man, a recently rediscovered fossil from China. It has a curious history.

Almost 90 years ago, Japanese soldiers occupying northern China forced a Chinese man to help build a bridge across the Songhua River in Harbin. While his supervisors weren’t looking, he found a treasure: a remarkably complete human skull buried in the riverbank. He wrapped up the heavy cranium and hid it in a well to prevent his Japanese supervisors from finding it. Today, the skull is finally coming out of hiding, and it has a new name: Dragon Man, the newest member of the human family, who lived more than 146,000 years ago.

Here, take a tour of the skull with Chris Stringer:

That is a big head-bone! The most provocative idea about it is that it might be one of the mysterious Denisovans, known only from DNA and fragmentary teeth.

I’ve been so deeply steeped in spider lore lately, though, that my perspective has shifted to finding it hard to believe in species anymore anyway. It’s cool to see that humans were also a diverse clade with subtle variants 150,000 years ago, almost as messy and complicated as, say, the Tetragnatha.

What is intelligence anyways?

I gave a talk titled “The Biology of Intelligence” on Sunday to the Atheists of Florida. It went OK, I think, with some of the familiar problems of Zoom talks. I sound a bit like a Dalek at times, and early on I had a catastrophic crash — my computer went down hard and I had to restart it all — but we muddled through.

I’m not a fan of the concept of “intelligence” — it’s something we can’t define and can’t even objectively measure, yet we seem to be comfortable saying that one species is more intelligent than another. A lot of the biology research seems to be contrived towards finding morphological correlates that align with our intuition, which is just plain bad science. Maybe I just don’t trust it because nobody ever intuits that spiders are the smartest species on earth.

What you’re missing today

The Tuesday schedule from the American Arachnology Society meeting:

I’m really looking forward to the plenary, and I know there will be lots of good stuff in the contributed talks, but boy, those were fatiguing yesterday. Also one session did not keep very good time, went way overlong, and rode right over the one break. Hey, coordinators, it’s really important to keep everything on time, otherwise when am I going to get to void all the coffee I was drinking through the meeting?

Also, the informal evening sessions are useful for us amateurs. I’m planning to sit in on the spider husbandry happy hour.

It’s going to be a spider kind of day

This morning I have to go into the lab and do upkeep on the spider colony and then I come back, put a big diet Coke by my side, and settle down to this schedule.

It’s time for the grindy part of the meeting! See that “contributed talks” bit? That’s 5 hours of 15 minute talks, one after the other, with occasional breaks during which, in a normal meeting, you’d mill around and talk to other people, but here in Virtual World I’ll just get up and stretch and walk in circles in my little office, I guess. They have concurrent tracks, so I can’t possibly see all the talks and have to miss half of them, so I think I’ll have to focus on the evo devo stuff, and then behavior, and then ecology & diversity. It’ll be a grueling session, but I’m looking forward to it.

Then we do it all again tomorrow.

Then again on Wednesday morning.

There are conveniences about online meetings, but I’m still hoping to go to the in-person meeting next year at UC Davis.

Nicholas Wade is the Andrew Wakefield of molecular virology

For the past month or so, my inbox has been inundated with letters insisting that they have proof of the lab leak hypothesis for the origin of SARS-CoV-2. Their insistent missives are full of jargon, like arginine codons and furin cleavage sites, and insistence that the particular sequence found in the virus could not possibly have arisen naturally. I am not an expert in viral genomics by any means, so my usually reply is a shrug that I don’t know the details, but I find their claim that the viral sequence could not have appeared by natural causes to be naive and unlikely, and that their probability argument is not a clincher. I’ve usually refrained from pointing out that they sound exactly like a few generations of creationists I’ve had to put up with.

A lot of that jargon and argument can be traced back to an article by Nicholas Wade in which he made those very same claims. I tend to veer away from anything by Wade — his embarrassingly bad book that advocated for “race realism” convinced me he’s not a trustworthy source — so I didn’t dig deeply into it. He seems to have persuaded some people, including David Baltimore(!), who has since retracted his endorsement of Wade’s “smoking gun”.

A science writer I trust far more, Thomas Levenson, explains what’s wrong with Wade’s claim.

Wade asserted that a particular arrangement of a specific sequence in the viral genome, called a codon, was unlikely to have gotten there naturally. There are actually six different codons for arginine, and the one found in a particular region of the SARS-CoV-2 genome called the furin cleavage site does occur less frequently in viruses than it does in the human genome. An even more telling detail to Wade is that this uncommon arginine codon shows up twice in that small segment of the virus’s genome. For that to occur naturally, Wade wrote, “a chain of events has to happen, each of which is quite unlikely.”

That’s what Baltimore assented to. But scientists say Wade misdescribed critical links in his chain. Scripps Research virologist Kristian Andersen led an early inquiry into the possible role of a lab escape in the origin of the virus, which concluded that it “is not a laboratory construct,” a finding that Wade termed “poor science” in his article. After Baltimore’s quote became public, Andersen re-entered the argument, and became one of a number of researchers to challenge many of the details Wade relied on. Andersen told Nature that Wade’s claim that steps in the emergence of the virus were too improbable to have occurred is not true. Rather, the pandemic virus uses that codon about 3 percent of the time that its genome calls for arginine—not common, but not impossibly scarce either—and, importantly, that other coronaviruses make use of it too, at similar or greater frequency.

Columbia University virologist Vincent Racaniello says the unusual pairing of a particular codon that Wade saw as decisive actually points away from laboratory manipulation. “We have some idea why this codon is rare in RNA viruses,” Racaniello says. Selection pressures have been identified that would discourage its use in viral genomes. But, he says, “We don’t know why it’s not zero. The fact that it is conserved in many viruses means that it’s beneficial in some way we don’t understand.” This is the kind of mystery that evolution throws at researchers all the time. Racaniello adds that if a lab researcher was trying to modify a virus to measure its effect, the researcher wouldn’t use the codon pairing identified by Wade because its effect would be too unpredictable.

I’d had an uncomfortable feeling with any argument that claims a low probability makes something impossible, because improbable things happen all the time. But 3%! That’s not low, especially not when you’ve got a virus with a population of trillions.