A distinction without any meaning

Biologists have managed to reprogram stem cells taken from a male mouse into female oocytes, then fertilized them with sperm from another male mouse, and produced healthy offspring — that is, they’ve made mice with two fathers. This is an expected, incremental advance in stem cell research, and not surprising at all.

The creationists at Answers in Genesis are made somewhat uncomfortable about this, since it violates their fantasies about the rigidity of sex determination, and recruited their tame in-house crank with a Ph.D., Nathaniel Jeanson to write a rationalization for them. It’s pathetic. He correctly summarizes the basics of the procedure, but then his brain falls out.

He decides that what he just described didn’t happen.

But can two adult males (mice, in this case) have their cells reprogrammed to produce eggs? Don’t males normally produce sperm, not eggs? How can offspring be produced from “two dads”?

In short, they can’t.

But that’s what the experiment did: they reprogrammed cells from adult males to produce eggs. His little essay described exactly what they did, which was that. How does he suddenly backtrack on everything?

For two males to reproduce, you have to first convert the cells from one of the males into female cells. And no, I’m not talking science fiction. This is what the researchers actually did.

They first reprogrammed cells from both male mice back to an embryonic state. At this stage of the process, the cells were all still male—possessing both an X chromosome and a Y chromosome. Then they waited for cells from one of the males to lose their male genetic material—the Y chromosome.4 At this stage, these genetically deficient cells now possessed only a single X chromosome, no Y chromosome.

These genetically deficient cells were poor candidates for producing eggs. To produce eggs, you need cells that have two X chromosomes. Consequently, as a next step, the researchers chemically induced these genetically deficient cells to return to a “normal” genetic state. They chemically forced them to have two chromosomes again—to realize an XX (rather than XY) chromosome state.

Effectively, they deleted the genetic instructions for “male” from one line of reprogrammed male cells, turning them genetically into female cells. Voilà, now they could produce eggs.

Yes? They took cells from a male mouse and turned them into female cells that could differentiate into eggs. They produced offspring from two dads. In short, they can.

It’s only been done in mice, and it’s a long, long way to being repeatable in humans, but this is exactly the procedure two gay men could use to have children together. Jeanson wants to argue, though, that the male mice did not have children — instead, he produced a “daughter,” a single cell, that then produced offspring.

By the way, if this strikes you as impossible, consider the fact that adult males regularly produce females. Dads have sons and daughters. Normally, these females (daughters) are produced with the help of a woman. In this study of two “dad” mice, the female “offspring” were produced in the culture dish—in a process that, in some respects, resembles the process of cloning.

So, no, two “dads” did not sire offspring together. Instead, using new genetic tools and tricks, researchers bypassed the normal process of reproduction to turn male cells into female cells and then joined the resulting sperm and egg.

Thus, even these researchers could not circumvent the biological realities for gender that God hardwired into creation from the beginning. They just went about the process of reproduction in a more perverse way.

By this goofy reasoning, no adult is a parent — we only produce spermatogonia/oogonia, single celled precursors to gametes, that are the actual parents, and mommies can be nothing but a transient single-celled stage on the way to making a zygote. Those “hardwired” “biological realities” seem to be entirely circumventable, although only with considerable technical finagling. Or, if you prefer, we could argue that his god has incorporated some remarkable flexibility in how sex develops.

I mean, seriously, two daddy mice did have offspring together. That’s the simple blunt reality of this result.

Get used to it.

Maybe my wife thinks I’m Ben Shapiro?

Mary is off to spend a week with our granddaughter, and it’s been a struggle. She’s supposed to have just gotten her own priorities straight — you know, packing, loading the car, that sort of thing — but instead she’s been fussing over me, as if I’m going to be helpless.

The cat’s even worse. When she sees luggage appear by the back door, she knows something is up and has been freaking out and puking all over the place.

I’ll be fine. I got a week’s worth of lectures organized and queued up this morning, and am looking forward to making a jambalaya loaded up with shrimp (Mary doesn’t like shrimp, so usually have to leave them out), and then, of course, the wild parties at my house starting tonight.*

*There will be no wild parties, sorry to say. Teaching resumes Monday.

Ken Ham really doesn’t get science

One of the more damning testimonies from Ken Ham occurred in his debate with Bill Nye, in which he declared that no evidence could ever change his mind (so why bother debating him, I would ask?). Now AiG has turned that sentiment into a poster-sized meme that only shows that they’re not scientists.

Ken Ham:
Evolutionists have to changing their ideas as more evidence (contradictory evidence) keeps coming.

Isn’t that the whole point of science? You keep gathering empirical evidence and adjust your interpretations as you go, in order to keep your hypotheses and theories in alignment with the real world. It’s how science hones itself and gets better and more accurate.

Poor creationists. They have to close their eyes and ignore all the evidence that contradicts their perspective.

(via Dan Phelps, because the AiG web site makes me nauseous.)

Degenerates!

Men these days have decayed from the power and virility of their forebears. Think of those mountain men who’d go off into the wilderness alone and hunt and fish and trap and live off the land, to return after months or years with a sledge loaded with valuable animal pelts. They were awesomely self-sufficient. We have degraded over time, to the point where some men are little more than weak parasites on society who depend on others to tend to their frail, fragile selves and pathetic needs.

I speak, of course, of American conservatives.

These smug, self-satisfied little ‘men’ chortle and laugh as they’re asked if they would rather do dishes or laundry…and admit with an air of pride that they don’t do either. Not only are they ineffectual and incapable, they are vain about their deficiencies. It makes them a special elite, I guess.

Listen. It makes them spineless atavisms.

Here’s what a real man should be able to do:

  • Cook a healthy meal.
  • Clean up after themselves.
  • Maintain their clothing and their home.
  • Sew a button.
  • Humanely remove a spider from a room without squealing.
  • Change a diaper.
  • Have a relationship with a partner, not a servant.
  • Call their mother.
  • Cry when appropriate.

(This is what a real woman should be able to do, too, so maybe it’s a list of what real humans do.)

These guys have gone from whining about “stand up straight” and “clean your room” to bragging about their incompetence at elementary chores. I do all those things, including washing dishes and doing laundry, and I’m a wokefied candy-ass liberal who uses pronouns.

On the bright side, American conservatives are on the road to extinction.

Texas being Texas

Texas, not satisfied with wanting to ban critical race theory, ending colleges’ diversity, equity, and inclusion policies, and eliminating tenure, has set its sights on banning people from countries conservatives don’t like with HB 4736.

PROHIBITED ADMISSIONS. Notwithstanding any other law, an institution of higher education, as defined by Section 61.003, may not admit an applicant for admission to the institution as a student if the applicant is:
(1) a citizen of China, Iran, North Korea, or Russia;
or
(2) not authorized under federal statute to be present
in the United States.

Honestly, I’ve never had a North Korean student — the North Korean government isn’t big on exposing their citizens to strange foreign ideas, much like the Texan government. I’ve had lots of Chinese students, and a few Russian and Iranian students. They’re fine. They’re often more motivated than American students, and if they go back to their home country after a few years with a little sympathy for the US, that’s a net gain for us. Or if they decide they want to stay in the US, that’s also a net gain. We can’t lose by freely sharing education with the world (it’s also a good idea for American students to study abroad). We all win.

Unless, of course, your goal is to make sure your citizenry doesn’t understand and hates foreigners from certain countries that have been currently designated as an enemy.

The raccoon dogs, and the virus, didn’t intend to kill us

Some people have been pushing the idea that COVID-19 was artificially created in a Chinese lab. There’s no real evidence for that — the virus itself doesn’t contain any labels of its origin, that a research lab in China was studying the virus isn’t evidence of manipulation (a research lab researching is what research labs do), and the people promoting the ‘lab leak’ theory all seem to have a political agenda to blame someone. I sure haven’t been convinced. Now there’s a new revelation: they’ve found genetic evidence from samples collected at the Huanan wet market that infected wild animals were there.

Way back in 2019, researchers were swabbing locations in the market and filing away samples for later analysis. Guess what? It’s later. Swabs sampled from a stall that was selling raccoon dogs have been sequenced, and they’ve found … raccoon dog DNA, which is no surprise. But they also found lots of SARS-CoV-2 mingled with it, which tells us that these wild animals were already infected with COVID.

A new analysis of genetic sequences collected from the market shows that raccoon dogs being illegally sold at the venue could have been carrying and possibly shedding the virus at the end of 2019. It’s some of the strongest support yet, experts told me, that the pandemic began when SARS-CoV-2 hopped from animals into humans, rather than in an accident among scientists experimenting with viruses.

“This really strengthens the case for a natural origin,” says Seema Lakdawala, a virologist at Emory who wasn’t involved in the research. Angela Rasmussen, a virologist involved in the research, told me, “This is a really strong indication that animals at the market were infected. There’s really no other explanation that makes any sense.”

I’ve never been that interested in the question of its origin. I already know that we live on a planet of viruses, with an unimaginably huge population of diverse viruses squirting their DNA and RNA into every available creature, genetic material that is constantly mutating at a rapid rate, and what we ought to be amazed at is that we have molecular mechanisms of resistance, an immune system, that can cope with it at all. It was inevitable that something would evolve to get past our defenses, and that we’d have to adapt or die. That’s what we’ve been doing for the entirety of the existence of life on Earth.

That life changes and that there are naturally inimical forces that exist is an uncomfortable truth for many people. They’d rather think that a threat is by intent, that it had to be designed, and that the solution is to march out and do battle with a hostile, and purposeful, enemy (in this case, all of China. Good luck with that, I’d rather deal with it by improving public hygiene and developing new medicines.)

Now, can we stop wasting time looking for someone to blame, and refocus on dealing rationally with the pandemic? Unfortunately, there are many people who think the way to deal with a threat is to ignore it and pretend it has gone away. It hasn’t. The viruses keep on changing, thriving on the neglect that gives them an opportunity to proliferate in all these hosts who have given up, and it’s only going to get worse.

Fun with a “natural theist”

How about some low-lying fruit for a light afternoon snack? Here’s a cocky believer to nibble on.

Atheism is the greatest moral error because it breaks the greatest command demanded from humanity: “Love the Lord your God with all your heart, with all your soul, with all your mind, and with all your strength”.
Mark 12:30

Oh. OK. Atheism is bad because a god-priest says it is. This is not the gotcha he thinks it is.

These guys will never settle for nebulous, vague assertions about an invisible being. They’ve also got to go after science with a vicious punch of ignorance.

Natural selection is a euphemism for no real force. Environment, social pressure, survival, etc. These do not guide consciously the process of genetic traits or modifications. I mean, the ‘environment’ is non-conscious, non-rational and Ignores what is happening.

Except…by accident, he’s sort of right. The environment is non-conscious, non-rational and ignores what is happening. I suspect he thinks that is an argument against evolution though, because he assumes evolution has to be conscious and rational.

Also, a lightning bolt is non-conscious, non-rational and ignores what is happening, but try to deny that it’s a force if it hits you.

Lying liars are still lying

I’ve been hearing a lot about how the collapse of Silicon Valley Bank, a bank in the heart of tech bro country, where Peter Thiel kept his money, was due to it being too woke. Go woke, go broke, as they say. As it turns out, the claim is contrived nonsense.

According to stories bursting across the right-wing mediasphere today, a key reason for the collapse of Silicon Valley Bank (SVB) was its focus on spreading “woke culture” rather than efficiently managing risk and profits. Ground zero for this is the allegation that SVB had donated over $73 million to the “BLM Movement & Related Causes.” That struck me as quite a lot of money for a single company, even a large and profitable one, to give to any cause or even all causes. So I tried to find out where this factoid came from and rapidly found my way to a Trumpist think tank. Perhaps not surprisingly, it’s a complete lie. I want to show you the receipts, but first some key details.

The story came from an “analysis” from the Center for the American Way of Life, a project of the Claremont Institute. You can tell from the name it was going to be a skeevy, dishonest organization, where they conflate “American” with “Capitalist”. What they did was compile all charitable donations to a huge range of organizations under one umbrella they called Black Lives Matter…not that BLM isn’t an unworthy recipient, but that they threw in so much money that any grass roots organization would have no way to spend it all.

Basically, if a donation benefitted a black person in any way, it was “BLM”. For instance:

Claremont lists 3M pledging a whopping $50 million to “BLM.” But the cited document, published in September 2020, appears to be mainly focused on supporting STEM learning in Black communities. It’s a pledge of $50 million over 5 years and lists $6 million in initial investments. That $6 million consisted of $5 million to the United Negro College Fund for work in St. Paul, Minnesota; another $1 million is slated for “annual investment to social justice partnerships, led by our employee resource network community champions and building on the initial investment from 3M Foundation in 2020.”

For Claremont, these are all “BLM.”

Oh, look, Boeing supported BLM! Not really.

Then there’s Boeing’s $15.6 million to “BLM.”

You can see the cited list of recipients here. The largest recipients include the Seattle Children’s Hospital, United Negro College Fund, Chicago Urban League, D.C. College Access Program and the Forum to Advance Minorities in Engineering, Inc.

My favorite, though, is Bank of America.

Rather unbelievably Claremont lists Bank of America as giving more than $18 billion to “BLM.”

Yes, billion.

The cited documents appear to report only $1.25 billion and that appears to be almost entirely going to financing for housing and business development in minority communities. So this money may be targeting minority advancement, but its in the form of loans that BOA will get paid back for. An apparently tiny fraction of that total (no specific numbers are cited) goes in grants to organizations like Asian Americans Advancing Justice, National Coalition for Asian Pacific American Community Development and The Leadership Conference Education Fund.

Bank of America gets a big chunk of change from me every month, since they hold my mortgage. Which means, by the transitive property of the Claremont Institute, that I am giving a large fraction of my income to BLM every month.

The vast majority of the organizations are highly mainstream and even corporate in their focus (supporting minority-owned small businesses, recruiting minority employees in STEM fields). The ones that aren’t mainly focus on housing, closing gaps in medical care in minority communities and supporting STEM education and coding. In many cases, the cited documents include no information to support the purported dollar amounts at all. In some cases a claim about one corporation is backed up with a document about another corporation entirely. So there’s a high degree of slapdash and incompetence involved. But the general message is that anything in any way connected to Black people in pretty much any way is “BLM riots,” and explicitly supporting mayhem and violence.

Slapdash and incompetent is a good summary of most conservative organizations. Add in dishonest and it’s perfect.

43

Today is our 43rd anniversary, and this morning I was thinking about our wedding.

It was a nice wedding, not too fancy, not too stressful, exactly as my wife-to-be planned it. There were many people there: family from both sides, and lots of familiar friends from the University of Washington, where both of us had attended (I’d recently graduated and had moved to Eugene, Oregon, where Mary would shortly follow). We’d been living in the dorms on campus, and had a close-knit crew who’d been applying to the same rooms year after year — 5th Floor Lander Hall, represent! There was the gang I played D&D with. Of course my two best friends since Junior High, Steve Klopfstein and Steve Dixon, were in attendance. These were all people I liked very much, and was happy to have a little party with them.

As I was reminiscing, though, I realized that this was also the 43rd anniversary of leaving all those good friends behind. I was never very good at being sociable, and immediately after the wedding Mary and I were off on our peripatetic academy journey, and we lost contact. I didn’t tell them how much our friendship mattered, and I drifted away, no forwarding address provided (not that it would have mattered, we moved so often over the years), and didn’t even try to stay in touch. I was the flavorless marzipan groom, I could stand woodenly on the cake, and do nothing but fail to communicate, no matter that I wanted to.

I guess my shriveled little heart only had enough love for one person there. At least that’s held up for a good long while.