World Polio Day

Lines on the return of Polio

A mother, doing what she thinks is right
Believes the lies and chooses now to fight;
She will not vaccinate. She is too young;
How quickly we forgot the iron lung.

So today is World Polio Day, and the news is mixed. The good news is, it’s still a preventable disease, and it’s roughly 99% eradicated.

The bad news comes from the Global Polio Eradication Initiative’s third report (pdf; do read it–it’s a remarkable report)– there are continuing deficiencies and weaknesses in the global eradication programs. With the exception of India and Angola, every country where polio persists has more cases this year than by this time last year. Three countries have already exceeded last year’s totals. The goal of worldwide eradication by 2012 is not quite impossible, but extremely unlikely at this point. Ineffective strategies continue to be pursued and politics (in both the national and internal senses) gets in the way of goals.

The problems vary from country to country, from war to ineffective leadership of eradication programs. The report is remarkable in its frankness; I hope that the people they criticize are willing and able to change.

Prayer ‘Cure’ Kills Three

Throw away your medicines!
God alone can cure!
Trust in Him, repent your sins
Make sure your thoughts are pure!
God can cure your HIV
With love that never fades
Trust in Him, and you will see
He’ll cure you of your AIDS
God’s healing is omnipotent
And infinite in worth
It brings an end that’s heaven-sent
To illness on the Earth
So throw away your medicines
Sing praises to His name!
And when your illness kills you, then
Your lack of faith’s to blame.

Deadly pinheaded faith-healing nonsense, after the jump:
[Read more...]

Throat In A Jar?


The same methodology used to produce
The remarkable “heart in a jar
Has created a trachea, almost from scratch,
And it looks like it’s working, so far!
The organ was made from the stem cells extracted
From marrow they drew from her hip,
And a collagen shell from a donor cadaver
Whose windpipe was one they could snip.
The trachea, treated with antibiotics
And stripped of its cellular coat
Was a scaffold to seed with her stem cells, to grow
A replacement for part of her throat!
So far it appears her recovery’s perfect,
The part’s recognized as her own;
What remarkable news! No concern of rejection—
It matches… because it’s home-grown!

Wow! This is just so incredibly cool! NPR’s “All Things Considered” reports on a trachea transplant success story with a twist–the new trachea was constructed using the recipient’s own stem cells!

Doctors in Spain have implanted a new windpipe into a woman whose airway was badly damaged by tuberculosis.

The pioneering operation used a section of windpipe engineered in a laboratory with adult human stem cells, according to Dr. Paolo Macchiarini, of the Barcelona’s University Hospital Clinic.

The stem cells were extracted from her bone marrow, cultured, and treated with chemicals to induce them to develop into cartilage, fat, and other tissues.

As the cells were growing in England, scientists began work on an even more crucial step — fashioning a kind of scaffolding out of tissue on which the new cells could grow.

They started with a trachea — a portion of the windpipe — taken from a 51-year-old man who had recently died.

The donor’s trachea was rinsed with antibiotics and most of the cells were removed with various detergents and enzymes, a process that took several weeks.

What was left was the shell of the trachea, essentially made up of fibrous collagen.

Yup, pretty much the same process as the heart-in-a-jar.

Over a period of four days, they applied nutrients and chemicals to promote the growth of new layers of tissues, which were composed of the same kinds of cells normally found in the trachea.

The airway was kept in a special container and rotated continuously to ensure even growth.

On June 18, Castillo underwent surgery in Barcelona to have a portion of her airway removed — specifically, the left bronchus.

Surgeons took the newly created windpipe and trimmed it to the proper size and fit it into place near the point where the trachea divides to supply both lungs.

The operation was in June, the report is out in today’s issue of The Lancet. So far, all is going well, without the need for anti-rejection drugs, because the body is recognizing that these are her own cells! That’s her picture at the top of the post–I bet it wasn’t hard coaxing a smile!

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T. M. I. (too much information)

…No, not the wonderful song by Roy Zimmerman, just letting you know that you might want to stop now, if you don’t like hearing about… well…

Oh, by the way, (Yes, this is by way of giving you enough time to change your mind–just don’t blame me, ok?) Roy Zimmerman’s new newsletter just came out; I’d copy it all here, but why don’t you just go to royzimmerman.com and look around for a bit? You won’t regret it. I have autographed copies of just about everything. Except the latest, I think. Roy is one of my idols (yes, I have a list–don’t you?).

Anyway, you now have officially had enough time to think “hmm, maybe he is serious about this too much information stuff…”, so at this point I am no longer responsible.

I had surgery last week. Yup. Wednesday. Been on painkillers since then, and what with the Myers vs Expelled stuff, I had my biggest hit day on this blog, for something written pretty much with just the reptilian part of my brain, because the rest was being used either feeling pain or watching the room decide which way to spin. And what does a cuttlefish do when bleeding, in pain and on oxycodone? Verse, of course.

Painfully, strainfully,
Digital Cuttlefish
Wishes his poetry
Showed some more class;

Sadly, effects of a
Hemorrhoidectomy
Limit his thoughts to his
Pain in the ass.

Yup, that’s a double-dactyl. They are fun. What is not fun, though, is the first bowel movement after a hemorh.. haeme.. after they cut part of your ass off. I thought I was fine–and I was, for the first couple of days. Took until Saturday for me to finally need to go… Now I know why they give opium derivatives. Ouch. ow ow ow ow ow ow owwwww….

Woozily, bruisily,
Suffering Sepia
Forces down fluids and
Tries not to strain;

Mutters his thanks to the
Pharmacological
Chemist-magicians who
Manage his pain.

I actually did thank the pharmacological industry. I mean, I know there are people in my position (prone, currently) who thank god for their drugs; I figure if you are gonna give credit for the drugs, ya gotta give blame for the piles in the first place, and then it just gets silly. So, no.

But I did have a great experience with the hospital people. My surgeon rocks–I’d say she kicks ass, but that metaphor is a bit lost on me at present. My nurses were great. I think, having read The Head Nurse’s blog, that they were in fact the A team; lots of confidence, good humor, helping one another. The nurse who put in my IV was hilarious. Watching her, I said “looks like you’ve done this before”; without missing a beat, she replied “no, but I did stay at a Holiday Inn Express last night.”

Anyway, time for bed. Whether I want to or not–oxycodone has that effect this late at night.

Sleepily, weepily,
Slumber is beckoning
Time to give thanks, cos it
Could have been worse—

Not to some deity,
Omnibenevolent;
I’ll give my thanks to each
Doctor and Nurse!

Good night, all.

Wonderful News! A Potential Cure For Diabetes!

A news release from Novocell today
Reports a major step to find a cure
For diabetes. They have found a way,
From embryonic stem cells, to make pure
And uncontaminated strains, in mice,
Of insulin-producing pancreas cells.
For human diabetics, this is nice
Of course, because this news potentially spells
The end to constant testing and injections,
Daily hassles, both the large and small,
Relief from greater risks of bad infections,
And generally a better life for all.
It’s time to end the ethical debate;
There’s too much cost in making people wait.

That’s right–The news outlets are all reporting on Novocell’s new discovery.

WASHINGTON (Reuters) – Human stem cells transformed into nearly normal insulin-producing cells when implanted into mice, possibly offering a way to treat diabetes long-term, researchers at a U.S. company reported on Wednesday.

The researchers used human embryonic stem cells — the most powerful but the most controversial source of stem cells.

Writing in the journal Nature Biotechnology, the team at San Diego, California-based Novocell Inc said their work showed that human embryonic stem cells might fulfill the promise of treating or perhaps even curing diabetes.

“Our data provide the first compelling evidence that human embryonic stem cells can serve as a renewable source of functional insulin-producing cells for diabetes cell replacement therapies,” said Emmanuel Baetge, chief scientific officer of Novocell.

The actual report is in the journal Nature Biotechnology (abstract here)

Oh… some of you know already… my son has Type 1 Diabetes. So yeah, I’m happy.

(just noticed….I beat the science blogs to this, and I did it in verse!)

Vaccination Fixation

Oh, pity poor Orac! He’s feeling the love of the anti-vax folks, who apparently think he is a stupid-head. So this one, like it or not, is for you, Orac.

It’s obvious that ignorance combined with desperation
And deliberate distortion mixed with misinterpretation
Not to mention giant leaps of overstressed imagination
May result in opposition to a helpful vaccination.

The Mercury Militia calls for more investigation
Till the government reveals what must be missing information;
A disinterested observer soon would see the explanation:
Anti-vaxxers, as a rule, misunderstand the situation.

The evidence is crystal-clear; I have no hesitation—
Quite the opposite, in point of fact, I have an obligation
To preserve the herd immunity throughout the population
For the sake of both my children and their children’s generation.

But the anti-vaxxers have a beef with modern medication;
I suspect that they’re the people who protested fluoridation
And who’d never take a pill when they could use an incantation
Or a regimen of regular colonic irrigation.

It is possible these whackos have an honest motivation,
Ah, but ignorance is toxic when in such a concentration,
And the Mercury Militia have attained a reputation:
They’ve developed an immunity to science education.

Though the latest of the studies you can find in publication
Once again, despite the protest, shows a lack of correlation—
And by rights should be the harbinger of end of disputation—
I suspect the odds are better we’ll see porcine levitation.

That conclusion, I imagine, may elicit some frustration,
And a straining reminiscent of a mental constipation,
But allow me now to offer you this meager compensation—
That at least this little verse of mine has reached its termination.

Matters Of The Heart (… in a jar)

It’s all over the news–researchers at the University of Minnesota have “created a beating heart in the laboratory“. Basically, they used the protein fiber matrix from one heart, stripped of muscle cells, as a scaffold upon which to grow a new heart, using a solution of cells from another rat. Yeah. I know, all this talk about hearts is so romantic. So, in a bit of a reversal from my previous position, I return to the romantic view of the heart as the foundation of love, with a trio of little verses inspired by the heart in the jar. I can see it now… the picture above, on the front of the Hallmark card, with one of the following verses inside…

I’m new at this game,

And I don’t know your name,

But I love you, whoever you are;

My heart may be true

But it’s also brand new

I grew it myself, in a jar!

I can feel my heart grow,

So I love you, you know, 

And not like a cousin or brother;

I will give you my heart–

Every bit, every part;

If you break it, I’ll grow me another.

My heart is yours; it’s in a jar
That sits upon your shelf;
It’s happy being where you are
And not all by itself.
You asked me for a souvenir
To keep while we’re apart;
I thought a bit, and it was clear—
It had to be my heart.
And now, although my heart may soar,
It is no longer mine;
A message that forevermore
I’ll be your valentine.

A rat cadaver’s donor heart
Is stripped of every cell
The protein fiber matrix left
Looks like a ghostly shell;
This matrix, in a sterile flask,
Is bathed in rat-heart goo
With both adult and baby cells,
And starts to grow anew.
In only days, the growing heart
May beat, or merely twitch,
Then work, at roughly two percent…

Like yours, you heartless bitch.

Juxtapositions (I just love that word)

Shelley, at Retrospectacle, once again has captured my attention. Plague week continues, of course, but another post will not be denied attention–how often do you get the chance to watch an egg-sized cyst, full of tapeworm larvae, being removed from a 16-year-old girl’s brain?

Yeah, I know, cool!

Cool…because the girl lives, and makes a full recovery. Because she lives in this century, rather than in a century when people saw the plague as God’s wrath, treatable by prayer, bleeding, herbs, mercury, or lucky charms.

You can complain about modern health care all you like. I take a bit of a wider view. It has saved my life on more than one occasion, has saved my son… There are old cemetaries in this area that are practically littered with infant and child graves, many where the child had not lived long enough to be named. Follow the link. Watch this huge cyst being removed from this girl’s brain. Be grateful to medicine, science, education… you live in a very good time to be alive.

A golf-ball sized hydatid cyst
Is not the sort of thing I’d list
As one I’d like to try.
Indeed, I’d rather think it marvy
Not to host so many larvae–
I’m not that kind of guy.

In juxtaposing these two posts
Where humans serve unwilling hosts
To tapeworms or bacilli,
And treatment may be surgery
Or bleeding, charms, or mercury,
You make my spine go chilly.

I won’t say much, but I concede
That in the past, I’ve had the need
To seek a doctor’s care;
I’m fine, of course, but even so,
I think: It’s not that long ago
My “treatment” would be prayer.

This girl here in your video
(My daughter’s age, I’ll have you know)
Is lucky as can be–
To live in this, the present day
Where science, not the church, holds sway
I hope that you’ll agree.

For her, and for my daughter’s sake
I’d like to take this chance to make
A science-based reply;
For researchers, for doctors, nurses,
Not for priests, or prayer, or curses
The stakes are much too high.

Danger! Warning!

When bloggers write, with laptops, seated,
Bits of them get overheated—
Sitting in their rooms, retreated
To their hidden cloisters.
If I should hear “Well done! Well done!”
I hope they mean my writing’s fun
And not some cruel and heartless pun
About my mountain oysters.

The writers putting out these blogs,
Like robots built with well-oiled cogs,
Or samurai, or feral dogs,
Eviscerate their fools—
But now, it seems they face a danger,
Not from any foe or stranger,
Simply from a heat exchanger
Near their family jewels.

Though Yossi Vardi starts to warn
It’s not time, yet, to be forlorn
(Though if your kids are not yet born
You’re one unlucky putz.)
It is, however, time to plan,
And if you are a hopeful man,
To buy and use a cooling fan.
Oh, yes… and shave your nuts.

Thanks to Greg Laden.

No vaccine for arrogance…

Orac reports on the latest pinhead celebrity to jump onto the anti-vax bandwagon. Yup, it’s that walking, talking hairpiece, The Donald.

The anti-vax pinheads are a group I find particularly annoying. My aunt had polio. My grandparents’ generation saw the Salk vaccine for the wonder that it is, and saw polio for the danger it is. Have we forgotten so much so quickly?

When polio was something that
Your friends and family got,
Damn right you’d wait in line to get
That magic-seeming shot.

When infant graves were commonplace,
Each parent knew the cost;
A victim of our own success,
Perspective has been lost.

But now that science gives our lives
More health and fewer pains,
True geniuses like Salk give way
To Trumps with shit for brains.

I’d bet if Trump was suddenly
Confronted with, say, cancer,
He wouldn’t hesitate to look
To science for an answer.

But ignorance and affluence–
A potent combination–
Are threatening the future of
A younger generation.

With every anti-vaxxer voice,
Our children’s risk enlarges,
And science must–for all our sakes–
Defeat these Trumped-up charges.