When it comes to research in experimental physics in areas that already exist, the frontiers that are usually explored are those of precision and size.
In the case of the precision frontier, the idea is to measure something more precisely than it has been done before because with greater precision there is a better chance of finding disagreement with theoretical expectations. Such disagreements (or ‘anomalies’), especially if they persist and are recognized as not being due to some errors in experiment or theoretical calculations, are the basis for thinking that there might be something new going on and may lay the foundations for some kind of breakthrough.
The other frontier is to extend the range of the parameters and in the case of high-energy physics, that means going to higher and higher energies. But this is enormously expensive. The Large Hadron Collider that was built at CERN at a cost of billions of dollars reached the existing energy limit and it resulted in the detection of the long-sought Higgs boson.
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