A story that will make your blood boil

Price gouging of US consumers by drug companies so that they can make enormous profits off patients so that they can pay their executive massive salaries and inflate their stock prices is a well-known scandal. Yet another example involves a drug known as Revlimid, marketed by a company Celgene to treat the bone cancer known as multiple myeloma.

When David Armstrong was diagnosed in 2023 with this disease, he began a quest to find out why a drug capsule taken daily that costs just 25 cents to make is sold for nearly $1,000. What he found is a tale of disgusting greed and cynicism by the people who run these companies, who kept raising the price over and over again, 26 times in all over the years, just because they can, uncaring about what it did to people desperately trying to live.

That steep tab has put the drug’s lifesaving potential out of reach for some cancer patients, who have been forced into debt or simply stopped taking the drug. The price also helps fuel our ballooning insurance premiums.

They also bought off doctors.
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RFK Jr. is going to cause the death of us all

It should be no surprise that placing an anti-vaxxer and conspiracy nut in charge of the department of Health and Human Services, the cabinet office that oversees almost all the science and public health agencies in the US, was going to do serious harm. And sure enough, he is wreaking havoc.

One of the more disturbing things he has done is cancel a long-running diabetes study that was looking at the effectiveness of a medication known as metformin. The group that got this medication was compared with another group that got a placebo and a third group that made lifestyle changes to meet health goals, such as to exercise more and lose weight.

The study found that, in people with prediabetes, metformin lowered the risk of diabetes by roughly a third; the life-style intervention cut the risk by more than half. Both components were so successful that the trial was stopped early.

But the The Diabetes Prevention Program Outcomes Study had planned to continue the study to explore other important questions, using the participants that had been enrolled in the earlier phase.

How long do the health benefits last? How do blood-sugar levels affect the body and the brain over time? For more than a quarter of a century, Nathan and his colleagues tracked thousands of patients—which was itself a feat of logistical and scientific endurance.(Many doctors struggle to get their patients to attend annual physicals, let alone engage them for a study of this duration.)

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Aircraft carriers can swerve?

It is much harder to steer a boat than it is a land vehicle. The presence of ground-based friction enables rapid changes in direction on land but that is absent in water. The bigger the boat is, the harder it is to change its direction of motion. I have sometimes compared large institutions to aircraft carriers, using that as a metaphor for how some of them change direction very slowly.

So I was surprised to read this report of an aircraft carrier engaging in zig-zag motion to escape hostile fire, with the resulting swerving being sufficient to result in a jet fighter falling into the sea.

US sailors had to leap for their lives when a fighter jet fell off a navy aircraft carrier that was reportedly making evasive maneuvers to avoid Houthi militant fire in the Red Sea on Monday.

The F/A-18 fighter Super Hornet jet, along with the vehicle towing it into place on the deck of the USS Harry S Truman, rolled right out of the hangar and into the water, the navy said.

Unnamed US officials indicated to CNN that the ship was swerving to avoid incoming fire from Yemen’s Houthi rebel force. Carriers make a zigzag maneuver when attempting to evade missile fire, causing them to list to one side.

It looks like I will need to find a new metaphor for large, slowly changing institutions.

The article seems to suggest that this type of swerving of aircraft carriers is not uncommon, which makes me wonder why there was no system in place to avoid this kind of catastrophe. It is likely because those responsible for making sure the plane was secured properly were DEI hires or transgender, because members of those two groups are the cause of all the ills that beset this country.

Here come the quackpots

Remember when, during the Covid-19 epidemic, Trump startled people in the medical community by suggesting that ingesting disinfectants could kill the virus? This was even more horrifying than his suggestions of using Ivermectin (the horse dewormer) and laser light as cures. It was not clear at that time where he got this crackpot idea but since he is full of crackpot ideas, people presumably did not think it worth tracking down the source.

But now it appears we know. The idea of using bleach was suggested by someone named Andreas Kalcker who markets chlorine dioxide, described as “a potentially life-threatening form of industrial bleach that is claimed without evidence to be a cure for cancer, Covid and autism.”

Andreas Kalcker is among 50 listed speakers at the “Truth Seekers Conference”, a two-day event opening on Thursday at the US president’s resort, Trump National Doral Miami. The event features several anti-vaxxers and other conspiracy theorists who have been brought together by the far-right commentator Charlie Ward.

Kalcker, a German national thought to be living in Switzerland, markets the bleach under the brand name “CDS”, for chlorine dioxide solution. His online brochures claim that the toxic chemical, which he admits is a disinfectant, can “eliminate pathogens” that cause disease.

He boasts it is “possibly the greatest medical discovery of the last 100 years”.

Government health authorities in the US and Spain have denounced the remedy as fraudulent, saying it is no different from drinking bleach. The US Food and Drug Administration (FDA) has warned that it can cause serious and even life-threatening side-effects, including dehydration, diarrhoea and kidney injury.

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Eggflation

One of the curious things is how the price of eggs has become the go-to proxy for the level of inflation in the country. This is due to Trump who during the presidential campaign kept talking about the price of eggs (and bacon) as being extremely high and blaming Joe Biden for it and promising that he would bring prices down on day one of his presidency. Of course, that was rubbish, like pretty much everything he says. Short of imposing direct price controls on specific items, the government has little sway over their prices. Trump has conveniently stopped talking about the price of eggs and indeed of inflation altogether which remains at the levels before he took office. He now says that it may take some time to get inflation down. Well, duh.
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Why is RFK Jr going to this funeral?

A second child has died in Texas, reportedly due to measles.

The US health and human services department confirmed the death to NBC late Saturday, though the agency insisted exactly why the child died remained under investigation. On Sunday, the New York Times reported that the eight-year-old girl had died from “measles pulmonary failure” early Thursday at a hospital in Lubbock, Texas, citing records obtained by the outlet.

It marked the second time a child with measles – which is easily preventable through vaccination – had died since 26 February. The first was a six-year-old girl – also hospitalized in Lubbock – whose parents had not had her vaccinated.

NBC and Axios reported that the Trump administration health secretary, Robert F Kennedy Jr, was expected to attend the funeral of the second child, with the service scheduled for Sunday.

If the cause of death is still under investigation by the department of HHS, the department run by antivaxxer RFK Jr. , why is he going to the funeral? To urge people to vaccinate their children? That seems unlikely given his past. What it suggests that he and the HHS know that she did die of measles and that he is trying to shield himself from the fallout of yet another needless death caused by his promotion of anti-vaccine propaganda.

I hope the mourners give him a piece of their mind, though if the parents of the dead child are vaccine deniers, they may not want to acknowledge their complicity in this senseless tragedy. The family belongs to the same Mennonite religious community to which the first child belonged. The parents of the first child stand by their decision not to vaccinate.

There is no convincing people when their beliefs are a combination of religious dogmatism and anti-science ignorance, even when it leads to a horrendous personal tragedy. When that dangerous combination is supported by high government officials like RFK Jr., then we are in real trouble.

The myth of universal body standards

When you go to a doctor, whether for a routine checkup or because of a specific concern, you will usually undergo a series of tests that will give values for a variety of biological markers. Your measures will then be compared with standard benchmarks to see if you fall outside the norm, and if you do, that will be perceived as a problem to be addressed. Implicit in this methodology is that there is a ‘universal patient’ whose biometric markers represent the norm that everyone should aspire to. But where do these norms come from? How valid are they? To what extent should they be used to diagnose and treat people?

When my older daughter was a baby, she was exceptionally chubby. But as she approached her first birthday, she rapidly became skinny, so much so that people had difficulty recognizing the infant in the photograph of her that was on the sideboard (taken at around six months) with the toddler now running around the house. In the regular doctor’s visits, her weight was always on the very low end of the standardized height-weight charts. But her pediatrician, who was an older man, did not seem concerned and so neither were we.
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Top health officials resign over Kennedy’s misinformation and lies

[UPDATE: ProPublica reports that “Leaders at the Centers for Disease Control and Prevention ordered staff this week not to release their experts’ assessment that found the risk of catching measles is high in areas near outbreaks where vaccination rates are lagging”. That has all the signs of Kennedy’s vaccine skepticism.]

Robert F. Kennedy Jr. has spent years peddling crank theories about vaccines and yet the Republicans in the Senate approved of his nomination to be the head of the department of Health and Human Services, the cabinet office that oversees almost all the agencies that deal with public health, such as the Centers for Disease Control and Prevention (CDC), Centers for Medicare & Medicaid Services (CMS), Food and Drug Administration (FDA), National Institutes of Health (NIH), and the Substance Abuse and Mental Health Services Administration (SAMHSA).

During his hearings he claimed that he was not a vaccine skeptic but anyone who has followed his career knows that he was being disingenuous at best, if not outright lying. And sure enough, top career people in those agencies are quitting, with one of them Dr. Peter Marks, pointing to Kennedy’s misinformation and lies as the reason.
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Science? We don’t need no stinking science!

The latest global rankings on university research by the journal Nature has been released and China has vaulted into the lead, with US universities sliding rapidly down.

In the last decade, a profound shift has taken place in global academia that has fundamentally altered the hierarchy of scientific research. China, once considered a peripheral player in cutting-edge science, has now ascended to the forefront of academic excellence. The latest Nature Index rankings reveal an astonishing trend: nine of the world’s top 10 research institutions are now Chinese, with Harvard University being the sole Western presence in the upper echelon.

This seismic transformation, while the Trump administration is instituting deep cuts in funding for research and shutting down the Department of Education, underscores not only China’s scientific prowess but also its strategic vision for global leadership in innovation and technology. To fully appreciate China’s meteoric rise, one must look back at the academic landscape a decade ago. When the Nature Index Global rankings were first released in 2014, only eight Chinese universities made it into the top 100. Today, that number has more than quintupled, with 42 Chinese institutions now ranking among the world’s best, surpassing the 36 American and four British universities in the list.
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Finding cause and time of death is messy

The story about Gene Hackman and Betsy Arakawa has thrown up new complications.

A private healthcare clinic in New Mexico has cast doubt on official findings about the timing of the death of Gene Hackman’s wife, Betsy Arakawa, claiming that she rang them on 12 February – the day after police say she died.
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Postmortem results indicated that Arakawa died of hantavirus, a rare rodent-borne respiratory disease, on 11 February, a week before her husband is believed to have died from heart disease. His pacemaker showed no activity after 18 February; he is also believed to have suffered from advanced Alzheimer’s disease.
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Dr Child cast further doubt on the official cause of death of his clinic’s prospective client, saying: “I am not a hantavirus expert but most patients who have that diagnosis die in hospital. It is surprising that Mrs Hackman spoke to my office on the phone on 10 February and again on 12 February and didn’t appear in respiratory distress.

A Los Angeles-based doctor told the Mail on Sunday: “Respiratory failure is not sudden – it is something that worsens over several days. Most people get admitted to the ER [emergency room] because they are having trouble breathing. It’s exceedingly rare for a seemingly healthy 65-year-old to drop dead of it. In fact, no one’s heard of such a thing.”

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