Behold! The resurrected mammoth!

Eat your heart out, George Church. The Australians have beaten you to the goal of resurrecting the wooly mammoth, and here it is:

It’s a meatball is what it is. Just a meatball. Probably not even a very good meatball.

Vow worked with Prof Ernst Wolvetang, at the Australian Institute for Bioengineering at the University of Queensland, to create the mammoth muscle protein. His team took the DNA sequence for mammoth myoglobin, a key muscle protein in giving meat its flavour, and filled in the few gaps using elephant DNA.

This sequence was placed in myoblast stem cells from a sheep, which replicated to grow to the 20bn cells subsequently used by the company to grow the mammoth meat.

“It was ridiculously easy and fast,” said Wolvetang. “We did this in a couple of weeks.” Initially, the idea was to produce dodo meat, he said, but the DNA sequences needed do not exist.

They replaced one protein in cultured sheep cells with a protein containing the mammoth sequence. That’s sort of it? I’m not impressed. There is much more to the flavor of meat than myoglobin: there’s fat distribution, muscle type, and pardon me, vegetarians, but also blood supply — white vs. dark meat. There’s texture, which is going to be in large part a product of activity in the living animal. None of that is here in that meatball. It’s the equivalent of those ‘nuggets’ made from pink slime.

And the creators are afraid to even taste it!

No one has yet tasted the mammoth meatball. “We haven’t seen this protein for thousands of years,” said Wolvetang. “So we have no idea how our immune system would react when we eat it. But if we did it again, we could certainly do it in a way that would make it more palatable to regulatory bodies.”

Oh come on. It’s mutton with a bit of elephant myoglobin tossed in. It’s mammal meat. People eat sheep and elephant without any notable reactions from their immune system, this isn’t going to be any different. The truth is they’re the people who saw the sausage being made, watched the cells getting filtered out of a flask, precipitated into a damp mass, compressed to squeeze out the tissue culture medium, and rolled out into a lump of homogenous goo and cooked. Of course it’s unappetizing. No worse than watching living animals being butchered, but still not something you want to put in your mouth.

The research team probably stood around the meatball when it was cooked, arguing about it.

“You first, Ernst.”
“No, no, the honor is all yours, Franz. I insist!”
“Ladies first. Sheila, would you like the first bite?”
“Uhh…umm…I already had lunch. I know! Mikey will eat anything! Mikey?”
“I have a better idea. Let’s just put it on a rock and take a dramatic photo.”

Now they’re flying the meatball off to the Netherlands, where it will be unveiled in a museum. Anything but eating it.

It’s not just a planet of straight white men anymore

Before fringe groups and weird haters hide behind the label of “science,” they really ought to more aware of what many scientists are actually saying, because they’re far more “woke” than you know. For instance, there is a strong movement within ecology and evolutionary biology to consciously revisit the history and assumptions of the discipline, with the EEB Language Project working to make the terminology more inclusive and recognize the biases in our history. This is a good thing, although some of the more senior members of the field will no doubt squawk about it. Too bad.

The group has just published a paper, “Championing inclusive terminology in ecology and evolution” that I’m filing away to use in the ecological developmental biology course I’ll be teaching in spring of 2024.

In recent years, events such as the coronavirus disease 2019 (COVID-19) pandemic and waves of anti-Black violence have highlighted the need for leaders in EEB to adopt inclusive and equitable practices in research, collaboration, teaching, and mentoring. As we plan for a more inclusive future, we must also grapple with the exclusionary history of EEB. Much of Western science is rooted in colonialism, white supremacy, and patriarchy, and these power structures continue to permeate our scientific culture. Here, we discuss one crucial way to address this history and make EEB more inclusive for marginalized communities: our choice of scientific terminology.

We provide background on how terminology influences inclusion in EEB, describe existing community-based initiatives and our new grassroots effort to champion inclusive language in EEB, and offer guiding questions and considerations for readers committed to using inclusive scientific terminology. This effort is particularly important for redressing the ongoing marginalization of many groups in EEB, including Black, Indigenous, and people of color (BIPOC) communities; lesbian, gay, bisexual, transgender, queer and/or questioning, intersex, and asexual (LGBTQIA+) communities; and disabled communities; among others. This work is motivated by the collective experiences, perspectives, and knowledges of our author group. Mitigating the institutional problems in EEB will take significant effort and resources, and examining the role of language in these problems must go beyond attention to scientific terms. It must also include consideration of how language is used among scientists more broadly, and how English is often treated as the dominant language for scientific work. Nevertheless, we propose that inclusion can be fostered by a collective commitment to be more conscientious and intentional about the scientific terminology we use when teaching, mentoring, collaborating, and conducting research.

This affects me, believe it or not. Just last week I was asked whether the spiders I study are an “invasive species.” I was brought up short — I’ve never thought of them that way, even though they are of Eurasian origin. “Invasive” carries an aggressive, dangerous, bad meaning to it, and on the fly all I could say is that they’re no more invasive than human beings, which is kind of damning if you think about it, and that as a synanthropic species house spiders just follow along and occupy the habitat we provide for them. I had found myself made uncomfortable by the implications of the accepted language we use to describe them! This is something other people have been aware of long before I was.

One way that terminology can negatively impact EEB is by creating environments in which students and researchers experience microaggressions, which are incidents that can adversely affect individuals from marginalized groups by perpetuating stereotypes and discriminatory attitudes. For example, one of our authors trained in the USA recalls ‘how tired I was as an undergrad hearing how invasive species from other countries decimate pristine US ecosystems. It reminds me of when people tell me or other people of color to “go back to where we came from”. Why would I want to be in a field that exoticizes immigrants or reinforces narratives that immigrants are a plague?’ Similarly, herpetologist Dr Earyn McGee describes how removing terminology that references historical racial violence against Black people can help create disciplinary environments that feel less exclusionary.

Now I’m wondering what other terminology I take for granted has disturbing implications. I welcome the opportunity to get educated.

By the way, “synanthropic” is a really good word — it just means that they are undomesticated animals that live together with us humans. People live in the company of a small collection of wild, naturally associated animals, like pigeons and raccoons and mice and innumerable small arthropods that find our homes and barns and garbage dumps totally copacetic. I like the fact that it generally lacks any pejorative sense, and prefer to think of it as a statement that there are animals that really like us and prefer our company.

Ken Ham really doesn’t get science

One of the more damning testimonies from Ken Ham occurred in his debate with Bill Nye, in which he declared that no evidence could ever change his mind (so why bother debating him, I would ask?). Now AiG has turned that sentiment into a poster-sized meme that only shows that they’re not scientists.

Ken Ham:
Evolutionists have to changing their ideas as more evidence (contradictory evidence) keeps coming.

Isn’t that the whole point of science? You keep gathering empirical evidence and adjust your interpretations as you go, in order to keep your hypotheses and theories in alignment with the real world. It’s how science hones itself and gets better and more accurate.

Poor creationists. They have to close their eyes and ignore all the evidence that contradicts their perspective.

(via Dan Phelps, because the AiG web site makes me nauseous.)

Too many spiders?

I admit, I might have a small problem. I came in to work this morning and found another egg sac had spewed out a bunch of adorable baby spiderlings. (This is a very low resolution shot, I hope the arachnophobes here can bear it.)

This is nothing new or surprising. I’ve had four egg sacs bear fruit since last week, so I’m getting used to it. I sit down and sort out all the spiderlings into separate vials, and tuck them away near the incubators. Not in the incubators — they’re all full of spiders already. They seem to do fine at room temperature.

Well, I think the future of the colony is more than assured at this point. If I raise 150 spiderlings to adulthood, I’d have to take over the neighboring lab spaces and maybe occupy the science building atrium, and I have about 15 more egg sacs waiting in various containers already. I’m going to have to draw a terrible, wicked line.

Future babies will not be coddled and given living quarters and free food. Instead, we have some experiments in microscopy and staining in mind, and they will be killed, quickly and humanely, thrown into fixative, and their bodies treated with various exotic chemical compounds before being mounted on a confocal microscope.

Oh jeez, I sound like a Republican.

Why would Tim White and UC Berkeley hoard old bones?

I organize spiders better than this

Berkeley has a bit of an unsavory reputation as the premiere grave-robbing institution in the US. They’ve got an impressive collection of looted remains.

More than three decades ago, Congress ordered museums, universities and government agencies that receive federal funding to publicly report any human remains in their collections that they believed to be Native American and then return them to tribal nations.

UC Berkeley has been slow to do so. The university estimates that it still holds the remains of 9,000 Indigenous people in the campus’ Phoebe A. Hearst Museum of Anthropology — more than any other U.S. institution bound by the Native American Graves Protection and Repatriation Act, or NAGPRA, according to a ProPublica analysis of federal data.

Tim White, the esteemed anthropologist, was in charge of repatriation decisions for many years, and basically stonewalled the process.

White said the collection did not need to be reported under NAGPRA because there is no way to determine the origin of the bones — and therefore the law does not apply.

The collection has exposed deep rifts at UC Berkeley, pitting a prominent professor who said he’s done nothing wrong against university administrators who have apologized to tribes for not sharing information about the remains sooner.

I’m looking at this as someone who is sympathetic to both educational and research needs, and I have to ask: why do you want these old bones anyway, Berkeley? They’re used to teach anthropology students, and I can understand why you want variations represented — one old mounted skeleton is not enough — but why do you need thousands of specimens for teaching the basics, and why do you need Native American skeletons shoveled out of their graves by the thousands? This makes no sense. It’s more like maintaining a dragon’s hoard then an actual, useful teaching collection. That’s especially clear when the collection is described.

By then, the teaching collection that anthropology professors used had grown to thousands of bones and teeth that White said in his report to university administrators had been commingled with others donated by amateur gravediggers, dentists, anatomists, physicians, law enforcement and biological supply companies.

The remains were unceremoniously sorted by body part so students could study them. A jumble of teeth. A drawer of clavicles. Separate bins for skulls. For decades, anthropologists added to the collection, used it in their classes and then passed it along to the professors who came after them, White said.

What use is an old bone if you know nothing of its provenance? What can you learn from a bucket of teeth?

For a moment I assumed that this would have been a massive, well-curated collection, where scientists can do research on comparative anatomy and variation. But no? This collection is just a pile of bones that professors have been letting students play with for decades. This is particularly appalling when various cultures have been begging to have the bones returned, and when the law is telling UC Berkeley to return them.

Recourse under the law was limited, leaving tribal nations to file formal challenges with the federal NAGPRA Review Committee, an advisory group whose members represent tribal, scientific and museum organizations. It can only offer recommendations in response to disputes.

In the first challenge following the passage of the law, in February 1993 the Hui Mālama I Nā Kūpuna O Hawai’i Nei, a Native Hawaiian organization, took a dispute over repatriation of two ancestral remains before the federal committee. The remains had been donated to UC Berkeley in 1935, at which time a museum curator classified them as Polynesian. White disagreed.

Addressing the committee, White introduced himself as “the individual who is responsible for the skeletal collections at Berkeley.” He argued the remains might not be Native Hawaiian and could belong to victims of shipwrecks, drownings or crimes. They should be preserved for study, he added, making an analogy to UC Berkeley’s library book collection, where historians access volumes for years as their understanding evolves.

White is admitting that they don’t know whose bones they have…then what use are they? His excuse for keeping them is that they might not be Polynesian, but could be from shipwreck victims. That is not a defense. That’s an admission that they have a hodge-podge, a confusing grab-bag of bones scooped up off of Pacific islands, and they don’t know what they’ve got…except that they’re going to keep them.

I’m trying hard to view this mess from the perspective of a college professor, but I’m not seeing it, and Tim White’s arguments for hanging on to these bones reads like a confession that Berkeley has been careless and sloppy. And White keeps stuffing his foot in his mouth!

In August 2020, White reported the contents of the collection he taught with to university administrators.

White told ProPublica and NBC News that given the lack of documentation, it would be impossible to determine if they were Native American, much less say which tribe they should be returned to.

“There’s nobody on this planet who can sit down and tell you what the cultural affiliation of this lower jaw is, or that lower jaw is. Nobody can do that,” he said.

It’s just the weirdest defense: our bookkeeping is so bad and ignorance is so great that we have no idea whose remains these are, therefore we ought to be allowed to keep them. To me, this is an argument that the whole collection ought to be shoveled out and given to people who would treat the bones with real respect. Berkeley seems to have a history of disgraceful disrespect and exploitation, and doesn’t deserve to be custodians of those dead people.

FREEEEEDOOOOMMM! For a few days, anyway

Today is my last day of classes before Spring break, and it’s going to be a busy one. After I finish up lab today, I’m free! Except for grading an exam and lab reports, and having to tend the students’ flies until they get back, and feeding my own monstrous swarm of arachnids every day. Other than that, I get to sit back and take it easy.

So let’s do a live stream tomorrow! I’ve got some rage bottled up in me about idiots denying evolution and climate change, plus maybe I’ll reveal some spider breeding tricks. Live! On air!

I do have to get through the rest of this day, though.

Disappointed, and relieved

This was supposed to be a heavy research morning — we’ve started a new experiment in the lab and spiders need to be assayed, and we were going to do some scanning of egg sacs with our confocal, and I was figuring I’d be neck deep in spider work until at least noon. But then my student called in sick, which was exactly the right thing to do (COVID is going around the student body again), and I had to postpone everything until Monday. I wouldn’t want to deprive her of the fun part of science!

Instead, I did the drudgery part of science, feeding all the animals. They didn’t really need it, they had mealworms earlier this week, and look like little brown beach balls right now. I wouldn’t want them to wake up feeling peckish and discover the larder was empty this weekend.

I found two new egg sacs. Two others look very close to emergence, so I sorted those out into new small containers. The confinement makes it easier to remove newly scampering spiderlings.

Now I’m staring at a stack of lab reports and exams and senior thesis drafts that I’m going to have to get done this weekend. I also have to compose a genetics exam to mail out this evening. First, though, I have to deliver another lecture to my other class. There will be no joy in Morris today.

This was supposed to be my light semester.

Science apologizes

We all knew William Shockley was a disgusting racist, using bad biology to argue for bad goals, but he was the co-inventor of the transistor! He won a Nobel prize for his work in a field unrelated to biology! So while my friends and I were willingly calling him out as a fraud, a liar, and a racist while we were out for beers, all the major scientific publications were more mealy-mouthed and ingratiating, which was annoying. It was partly out of misplaced politeness, but also that a lot of the white male old guard were probably sympathetic to his ideas.

Maybe that’s changing. Science has published an editorial apologizing for their past indifference/support for Shockley, and promising to do better. They’re calling out the racists and phonies.

Shockley was part of a cadre of physicists who advanced ideas outside of their area of expertise to promote a right-wing agenda. He was a close friend of Frederick Seitz—president of both the National Academy of Sciences and Rockefeller University—who, following a career in physics, became a purveyor of misinformation on tobacco, nuclear weapons, and climate change. Like Shockley, Seitz carried out his nonphysics work through op-eds and conservative think tanks, not through the accepted mechanism of peer review that he used in doing physics. Seitz was not, at least publicly, as overtly in favor of eugenics as was Shockley, but he was a strong advocate for genetic determinism, even claiming at the behest of the cigarette industry that tobacco itself was not harmful because genetics determined whether smokers would ultimately contract lung cancer.

Sound familiar? There are many ‘scientists’ getting checks from right-wing think tanks right now, although most of them are now busy with careers in vaccine and climate change denialism. The words have changed but the song is much the same. Let’s see Science start calling out more of the living hucksters and propagandists for the far right. But for now, I’m reasonably happy with their apology for propping up a dead one.

Following Shockley’s death in 1989, Nature correctly called out his racism in an obituary, but then published a letter from Seitz defending Shockley and claiming that the reason Shockley became a eugenicist was because of physical trauma he experienced in a near-fatal car accident. When Science wrote about this dustup, it referred to Shockley’s ideas as merely “unpopular” and “extremely controversial.” It then ran a letter from an even more notorious eugenicist, J. Philippe Rushton, who argued that by merely covering the disagreement at Nature, Science was delivering an “ad hominem attack.” In addition to an ill-advised decision to publish Rushton’s letter, Science posted a response saying, “no criticism of Shockley was intended.” Yikes.
Looking back, it’s clear that what was intended as an attempt to make room for dissent and discussion only served to abet Shockley and his cohorts in their effort to build support for eugenics. Science gave them a platform and inadequate scorn. The lesson is that we at Science need to make more effort to think about everything that we do, not only from the standpoint of communicating science to the public, but also as an organization that above all, supports all of humanity. The process of science is one of continual revision, but it’s also one that must have a conscience.
It was only a few months ago, in a commentary on racism in science by Ebony Omotola McGee, that Shockley was described in our pages in the terms he deserved. But as recently as 2001, Science described him simply as a “transistor inventor and race theorist.” That won’t cut it anymore. As of today, a link to this editorial will appear along with any mention of Shockley in this journal.
Make no mistake. Shockley was a racist. Shockley was a eugenicist. That’s all.

That’s a pretty good apology: admitting the mistake, taking the blame for it, and planning an action to correct their error. Not that it will stop all the modern ‘race realists’ from relying on old boobs like Shockley and Rushton in their arguments.

Heed the octopuses’ warning!

Here’s a story that has sex, octopuses, population genetics, and climate change, all at once.

What should catch your eye, after the octopus sex, is the shift that enabled those populations to meet across the vast (currently) frozen mass of ice of the Antarctic: a 2°C increase in temperature relative to the modern day. Just 2°C will cause an ice sheet collapse, dramatic rises in sea level, and an increase in the frequency of extreme weather.

Earth scientists continually emphasize that humanity isn’t inescapably doomed by the coming, inevitable disruptions to the climate. It’s just the opposite. Society still has an extraordinary amount of influence in the matter: The more warming, the worse the impacts. But Earth’s inhabitants should be aware that a 2 C world has extreme effects. It’s all the more reason to avoid any warming above 2 C.

The Earth has been there before. It’s not a world we’d enjoy living on.