There’s a study that identified a mutation relatively common in Ireland that can lead to acromegaly.
They undertook an ambitious and widely collaborative study, enlisting the invaluable help of patients and the general public to set the study up in Northern Ireland and Republic of Ireland. They identified a particular mutation in Irish patients and now searched for carriers of this gene in Ireland. The frequency of the AIP mutation (R304*) was found to be surprisingly high in Mid-Ulster, Northern Ireland. The data suggest that all Irish patients with this particular mutations (18 families and 81 carriers) are descendants from the same ancestor, who lived in the area 2,500 years ago. Out of the identified 81 carriers 31 had developed acromegaly and over half of these had gigantism (18 patients, 58%). The clinical importance of this study is that we can now screen family members and carriers can be followed to pick disease up early. Our larger study has showed that 24% of seemingly unaffected gene carriers in fact have early signs of acromegaly, and some were immediately operated as a result of the genetic screening process.
Sure. That’s interesting, and also, as they point out, useful.
But this is nonsense.
This study may also give a scientific explanation for the numerous Gaelic myth of giants in Ireland, where the Giant causeway and the legend of the creation of a lake is strongly linked to giants. In modern history, famous Irish giants include Charles Byrne whose skeleton in the Hunterian Museum, London was studied and DNA sample showed he also carries the same mutation. There is data available of numerous giants living in this area over the last centuries such as Mary Murphy (the ‘Portrush Giantess’) and James Kirkland (one of the ‘Potsdam Giants’) making this data support a colourful story.
Professor Sian Ellard, of the University of Exeter Medical School, who collaborated on the research said: “Irish folklore has numerous stories regarding Irish giants and the remains of some of these giants have been studied in the past. Our data provides an explanation for the observation made by the pioneering anthropologist James C. Prichard in 1826.”
Do no other cultures have folklore about giants? Scandinavian mythology is full of giants, and dwarves, too. The Chinese have a creator-god named Pangu, who was a giant. Greek myths have Titans. Do they all have associated mutations? Are AIP mutations the only source of giants in our species?
Why would you take a perfectly legitimate scientific explanation for a specific genetic abnormality and patch an unsupported pseudo-historical just-so story onto it unless you thought history was so trivial that you didn’t need evidence to make that kind of association?