Yesterday I picked apart the Burzynski clinic’s list of “scientific studies supporting antineoplason research since 2006.” Unsurprisingly, a majority of these citations were just abstracts of conference presentations lacking peer review, and a couple studies published in terrible (and even sketchy) journals. I wasn’t able to comment on specifics about the papers since I didn’t have access through my university.
A reader sent me a pdf of the first paper from Pediatric Drugs, which is even more incriminating. For one, it’s a review paper. Review papers summarize the current state of scientific knowledge about a certain topic. Sometimes they perform meta analysis on multiple papers, but they don’t always add any new information. Burzynski’s review falls into the latter – that is, it does not have any new peer reviewed data. And the studies about antineoplastons that the paper cites are from multiple conference abstracts, a patent from 1995, his report to the FDA, and an entry in a book by Nova Science Publishers (aka, also all not peer reviewed).
The only peer reviewed research paper the review cites was on the previous list – it was the one published in the crappy alternative medicine journal. I haven’t gotten hold of the paper, but commenter joshtriska summarized it thusly:
 A report on 18 patients with “High-Grade, Recurrent, and Progressive Brainstem Glioma” picked from 4 of his clinical trials. The conclusion states that typically less than 10% of patients with this condition survive 2 years, but in his group 22% (or four whole people) survived past 5 years. The conclusion also states that “Because a small number of patients have been evaluated, a larger study is required to confirm these results”. No kidding!
And that final paper – the one published in the sketchy as hell “Cancer Therapy” journal, was also a review:
 A review paper, not a study. Antineoplastons are mentioned and a line of data from one of Burzynski’s trials is included in a table. The discussion states that the data concerning antineoplastons was from from conference abstracts, and not peer-reviewed.
The Burzynski clinic is claiming that it’s libelous to say “There are no scientific studies supporting antineoplaston treatment since 2006.” But it’s not libelous because it is true. Results that lack peer review cannot be said to support something. Abstracts at conferences are not peer reviewed. Review papers do not include new, peer-reviewed data. The only published paper he has itself states that it is inconclusive without a larger study to confirm the results.
Plus, they don’t even understand what the phrase “since 2006″ means. It means published starting in 2007. From that alone we throw out the first two papers. You’re left with a review paper that cites conference abstracts, and conference abstracts.
So no, Burzynski clinic. There aren’t any scientific studies supporting antineoplaston treatment since 2006. But there are plenty falsifying it.