Magic RNA editing!

One of those wacky Intelligent Design creationists (Jonathan McLatchie, an arrogant ignoramus I’ve actually met in Scotland) has a theory, which is his, to get around that obnoxious problem of pseudogenes. Pseudogenes are relics, broken copies of genes that litter the genome, and when you’ve got a gang of ideologues who are morally committed to the idea that every scrap of the genome is designed and functional, they put an obvious crimp in their claims.

So here’s this shattered gene littered with stop codons and with whole exons deleted and gone; how are you gonna call that “functional”, creationist? McLatchie’s solution: declare that it must still be functional, it’s just edited back into functionality. He uses the example of GULOP, a gene responsible for vitamin C synthesis, which is pretty much wrecked in us. Nonfunctional. Missing big bits. Scrambled. With missing regulatory elements, so it isn’t even transcribed. No problem: it’s just edited.

As I mentioned previously, the GULO gene in humans is rendered inactive by multiple stop codons and indel mutations. These prevent the mRNA transcript of the gene from being translated into a functional protein. If the GULO gene really is functional in utero, therefore, presumably it would require that the gene’s mRNA transcript undergo editing so that it can produce a functional protein. It’s not at all difficult to understand how this could occur.

Yes, RNA editing is a real thing. RNA does get processed before it’s translated into protein. McLatchie has a teeny-tiny bit of knowledge and is abusing it flagrantly.

I’ve hammered out dents in a car, and I’ve touched up rust spots with a little steel wool and a can of spray paint. My father was also an auto mechanic and could do wonders with a wrench. Auto repair exists, therefore…

old-wrecked-car-outback-australia-14466708

…patching up that vehicle should be no problem at all, right? I expect to see it cruisin’ down the highway any time now.

Maybe two cans of spray paint this time…?

If Dr. Phil is a fraudulent hack, is it OK to respect his opinions?

No.

This has been a brief example of easy answers to stupid questions. For the longer version, take a look at Dr. Phil’s recent excursion into JAQing off over rape, where he asked if it’s OK to have sex with a drunk girl.

What’s also awful about that notorious tweet is that his twitter history shows what he’s doing: he’s trolling for story ideas for his ghastly little show. If you think that stupid question was bad, just imagine an hour of folksy Dr Phil trying to sympathize with a rapist who uses drugs to remove women’s ability to deny them.

Remember when TV was called a “vast wasteland”? That was in 1961. They hadn’t seen anything yet. If the FCC had seen Dr Phil coming then, they would have shut down all the networks on the spot.

And here I thought all Canadians were nice

The mother of a 13 year old boy with autism discovered this letter from a neighbor.

To the lady living at this address:  I also live in this neighbourhood and have a problem!!!! You have a kid that is mentally handicapped and you consciously decided that it would be a good idea to live in a close proximity neighgbourhood like this???? You selfishly put your kid outside everyday and let him be a nothing but a nuisance and a problem to everyone else with that noise polluting whaling he constantly makes!!! That noise he makes when he is outside is DREADFUL!!!!!!!!!! It scares the hell out of my normal children!!!!!!!!! When you feel your idiot kid nees fresh air, take him to our park you dope!!! We have a nature trail!! Let him run around those places and make noise!!!!!! Crying babies, music and even barking dogs are normal sounds in a residential neighborhood!!!!! He is NOT!!!!!!!!!!!!  He is a nuisance to everyone and will always be that way!!!!!! Who the hell is going to care for him????????? No employer will hire him, no normal girl is going to marry/love him and you are not going to live forever!! Personally, they should take whatever non retarded body parts he possesses and donate it to science. What the hell else good is he to anyone!!!! You had a retarded kid, deal with it... properly!!!!! What right do you have to do this to hard working people!!!!!!!!! I HATE people like you who believe, just because you have a special needs kid, you are entitled to special treatment!!! GOD!!!!  Do everyone in our community huge a favor and MOVE!!!! VAMOSE!!! SCRAM!!!! Move away and get out of this type of neighborhood setting!!! Go live in a tralier in the woods or something with your wild animal kid!!! Nobody wants you living here and they don't have the guts to tell you!!!!!  Do the right thing and move or euthanize him!!! Either way, we are ALL better off!!!  Sincerely,  One pissed off mother!!!!!

To the lady living at this address:

I also live in this neighbourhood and have a problem!!!! You have a kid that is mentally handicapped and you consciously decided that it would be a good idea to live in a close proximity neighbourhood like this???? You selfishly put your kid outside everyday and let him be a nothing but a nuisance and a problem to everyone else with that noise polluting whaling he constantly makes!!! That noise he makes when he is outside is DREADFUL!!!!!!!!!! It scares the hell out of my normal children!!!!!!!!! When you feel your idiot kid needs fresh air, take him to our park you dope!!! We have a nature trail!! Let him run around those places and make noise!!!!!! Crying babies, music and even barking dogs are normal sounds in a residential neighborhood!!!!! He is NOT!!!!!!!!!!!!

He is a nuisance to everyone and will always be that way!!!!!! Who the hell is going to care for him????????? No employer will hire him, no normal girl is going to marry/love him and you are not going to live forever!! Personally, they should take whatever non retarded body parts he possesses and donate it to science. What the hell else good is he to anyone!!!! You had a retarded kid, deal with it… properly!!!!! What right do you have to do this to hard working people!!!!!!!!! I HATE people like you who believe, just because you have a special needs kid, you are entitled to special treatment!!! GOD!!!!

Do everyone in our community huge a favor and MOVE!!!! VAMOSE!!! SCRAM!!!! Move away and get out of this type of neighborhood setting!!! Go live in a trailer in the woods or something with your wild animal kid!!! Nobody wants you living here and they don’t have the guts to tell you!!!!!

Do the right thing and move or euthanize him!!! Either way, we are ALL better off!!!

Sincerely,

One pissed off mother!!!!!

Speaking as a scientist here, I’m not at all interested in dismantling young boys for their organs, so I’m going to have to reject that suggestion. However, I do think someone with such a serious case of exclamation point abuse and hatefulness ought to be condemned to live in a small trailer in the wilderness with no other people about, with the Canadian government airdropping occasional packages of supplies (moose meat and poutine? Timbits for dessert? Whatever Canadians eat) so that she can live without the interruptions from other human beings. It’s the only humane thing to do. We’d all be better off.

SkepticDoc, M.D.

Do I place a higher value on reason, critical thinking, and skepticism or on the interpretation of feelings as accurate indicators of truth (e.g., if I feel harassed, I was harassed), arguments from experience, and the uncritical acceptance of third wave feminist ideology?

Some tendentious derpwad on the internet

All claims require evidence, whether they are extraordinary or not. And a claim, in and of itself, is not, by definition, evidence.

Some other derpwad on the internet

I don’t know what it is, but some skeptics have adopted this calcified attitude towards what constitutes reasonable evidence and reasonable claims. It seems to me that these are nothing but excuses contrived to justify denying reality, and that they are actually toxic to any kind of functional, societally useful version of skepticism; this is the skepticism of the status quo.

What if people actually operated as these advocates for purblind skepticism suggest? So I paid a call on SkepticDoc, M.D., the very acme of this form of skepticism. Here is how the visit went.

PZ: Doctor, lately I’ve been experiencing shortness of breath and an ache in my left shoulder when I exert myself…

SkepticDoc: Whoa, whoa, whoa, slow down! See the name on the shingle? It’s SkepticDoc. Do you have anything other than your feelings to justify wasting my time here?

PZ: What? I’m telling you my symptoms…

SkepticDoc: Yeah, yeah, your feelings. Do you have some physical evidence that you felt pain? Some independent corroboration that you felt this remarkable “ache”? So far, this is just gossip.

PZ: It prompted me to come here, pay money, face some physical discomfort, and apparently have my condition mocked and dismissed. But what you’re supposed to do now is test me, find evidence of the cause of the problem and help me get better.

SkepticDoc: Right. Sure. But why should I bother? Look, people live to be about 70 years old on average, that’s over 25,000 days without dying of heart disease. The odds that you’re actually experiencing these symptoms is really, really low, so it’s a waste of my time to take you seriously. Extraordinary claims require extraordinary evidence.

PZ: But I’m a 57 year old man with a family history of heart disease and a prior incident that required hospitalization! This isn’t extraordinary!

SkepticDoc: A professional victim, eh? Your kind are always in here giving me your sob story. Well, boo hoo hoo. Look at all the people who aren’t having trouble with heart attacks, and try to be like them. They aren’t in here taking up my office hours.

PZ: So you aren’t even going to examine me?

SkepticDoc: Oh, all right. I’ll take a look at your chart.

Hmmm.

Says you’re a college teacher, right? Made these same complaints a couple of years ago, same time of the year…right before classes start? Interesting.

Your job is a little stressful? You think another couple of cushy weeks in a bed with pretty nurses waiting on you hand and foot is looking pretty good right now? Yeah, I’ve seen your type.

PZ: Getting stuck in a hospital isn’t a vacation! And I like my work!

Wait, what are you doing? You’re supposed to be interpreting my medical history, not trying to psychoanalyze me. Yes, I have a history of heart disease. That’s why I’m being careful and coming to you now.

SkepticDoc: Aha, you admit it!

PZ: I admit what?

SkepticDoc: That this is your personal problem, and that you’re expecting someone else to help you. It seems to me we have a little problem with personal responsibility here. Grow a spine!

PZ: But…but…you’re a doctor. This is your job.

SkepticDoc: That’s right. I’m in charge. But my first job here is to find a reason and place the blame. By the way, I notice you’re a bit overweight.

PZ: Yes.

SkepticDoc: Stop it. Just stop eating. When someone comes by with a cookie or a hamburger or a carrot or something, just don’t eat it. If you find it hard to say no to a second helping, just leave some food on your plate. It really is that easy.

PZ: OK, mea culpa. I’ll watch the diet more closely. But this is a problem right now, I’m worried and I need your help.

SkepticDoc: What problem? I just checked the heart transplant registry, and your name isn’t on it. If this were a really serious problem, you’d have gone all the way to applying for a transplant immediately, so I think the fact that you’re taking a lesser step means your problem can’t possibly be that bad.

PZ: Huh? Are you suggesting I need a heart transplant? You haven’t even looked at me! I’ve detected symptoms of an onset of a possible problem, and I’m here taking an appropriate first step to diagnosis and treatment.

SkepticDoc: I don’t know. You look fine to me — you don’t seem to be having a heart attack now, your color’s good, if a little flushed, all the observable evidence says you’re not in need of any kind of medical attention. Why are you bothering me?

PZ: I told you! Chest pains!

SkepticDoc: And I told you, I don’t believe this personal testimony nonsense. And hey, didn’t you earlier say the pain was in your shoulder? Now you claim it’s your chest? You’re not very credible, liar.

PZ: <storms out>

A few minutes later…

Nurse: Dr. SkepticDoc! Dr. SkepticDoc! That man who just left your office … he has collapsed by his car, his face is turning purple, I think he’s having a heart attack!

SkepticDoc: You say. Do you have any evidence to back up that unusual claim?

[and…scene!]

This story has been entirely fictional. There is no SkepticDoc, M.D. in my town, and no humane and responsible doctor would express the kind of absurdly hyperskeptical attitude we see in the cited derpwads. Also, I’m in fine health and am not experiencing any chest pains…I mean, shoulder aches!

He clearly has a legitimate, vested interest

fuson

The guy who has been pestering Skeptics Guide to the Universe to fire Rebecca Watson, and is also associated with the always lovely pro-harrasment site A News, and who created the anti-Rebecca Watson facebook page, has been revealed. It’s Cecil Fuson. Mr Fuson really, really hates Rebecca. He’s really disgusted with this feminist stuff.

Mr Fuson is also a registered sex offender who was convicted and went to prison for “indecent liberties with a minor” in 2003.

It was probably those damned feminists who railroaded him.

<Cue shrieks of “Dox!” and “Free speech!” (oh wait, not that last one, this time)>

Finally, more people are waking up to @elevatorGATE’s abuse

I’ve compared him to Dennis Markuze before, and it’s exactly the same: using internet protocols and an abundance of free time to constantly harass people he doesn’t like with pointless, content-free noise. The offender goes by the pseudonym “@elevatorGATE” on twitter (right away, you can tell what inspired him), and he’s been doing this for years now, obsessively dunning his targets with noise. There are some differences: Markuze aims his vitriol at skeptics who questioned the existence of paranormal powers.

@elevatorGATE hates women.

Another difference is that Markuze is a despised loner, while @elevatorGATE is surrounded with a little cloud of filth, people who share his hatred and use @elevatorGATE as an amplifier and who love to cloak themselves in the indignant mantle of FREE SPEECH! What they really want is the opposite, though: their goal is to drown out dissent with persistent shouting, and preferably to drive their victims out of social media altogether. They’re more of the trollish toxin that’s poisoning the internet. They’re also the first to squawk if anyone makes an effort to personally block their intrusions — these are privileged idiots who feel it is their right to demand that we listen to them.

Their latest tool is to use Storify. @elevatorGATE constantly gathers up tweets into a little bundle and echoes them back repeatedly; it’s especially easy because when he does that, all of his targets get a little notification (I’ve had to set up my accounts to automatically trash all notifications because the noise is deafening and useless). Imagine dealing with a junior high snot who’s brilliant strategy for harassing you is to follow you around and repeat everything you say, over and over: that’s the brain of @elevatorGATE. And there’s the newest offense: he thinks he has the right to do that. And worse, the CEO of Storify has agreed.

Ana Mardoll and John Scalzi have posts up about this. Scalzi has published a letter he received about this problem.

A Twitter and Storify user who goes by the handle “@elevatorGATE” is a well-known cyberstalker of women via social media. His latest method of doing this is to compile thousands of pieces on Storify, often including every single tweet sent by his chosen targets, and then publish them, which notifies the women in question that he had published yet another piece archiving their every word. After repeated complaints and requests for help, Storify temporarily deactivated the notification feature on his account, which doesn’t actually solve the problem.

In a conversation yesterday with Xavier Damman, the Storify CEO suggested that the women @elevatorGATE is targeting turn off all notifications from Storify, which essentially suggests that they withdraw from the medium if they don’t like being stalked, and which also wouldn’t solve the problem of this user archiving everything these women say. One of the users pointed out that this is very much like telling a woman who is being harassed via telephone to never answer the phone. It was at this point in the conversation that Damman went from passively enabling a stalker to actively assisting one. He tweeted, in response to the women, that they “…can’t do anything about that. It’s @elevatorgate’s right to quote public statements…”

Prior to this point in the conversation, the women had named their stalker, but not used the @ symbol in front of his username. You know enough about Twitter to know why that’s a big deal. Damman either carelessly or deliberately notified a man stalking multiple women that they were seeking some way to prevent him from continuing to harass them, and then claimed it was no big deal because anyone searching for the information would have been able to find it. But there’s a very big difference between information existing and that same information being directly brought to a person’s attention.

If you know much about stalking, you’ll know what happens next. @elevatorGATE has substantially stepped up his harassment of the women who had asked Damman for help. Men who follow him on both Storify and Twitter have been bombarding these women via Storify notifications and Tweets with additional harassment. He has also increased his harassment of known online associates of the women in question, making it difficult for them to seek out help or support from fear of his beginning to stalk their friends as well. It’s the reason I’m contacting you privately, via email, rather than via social media: I’m afraid. I don’t want to be added to his list of targets.

Think about that. Damman runs a company that is utterly dependent on social media, and he’s so incompetent or so heedless that he doesn’t recognize the responsibilities or potential for abuse in his own software. He is unaware that his product is easily misused by stalkers. That should be a cause for a lack of confidence in Storify.

I do have to correct the letter above on one point. It refers to “Men who follow [@elevatorGATE]…”, but I also know of several women who also defend him and chortle along with his barrages.

@elevatorGATE should be getting the same treatment that Dennis Markuze got. His followers should be ashamed of themselves. And Damman should either work to correct his company’s product’s flaws, or he should go bankrupt.

Orson Scott Card is even worse than I imagined

He’s also a racist conspiracy theorist. I’m not a fan of Obama myself, but Card’s ideas are hateful and loony — he thinks Obama is going to place Michelle Obama in the presidency with a force of “national police”.

"Where will he get his ‘national police’? The NaPo will be recruited from ‘young out-of-work urban men’ and it will be hailed as a cure for the economic malaise of the inner cities.

"In other words, Obama will put a thin veneer of training and military structure on urban gangs, and send them out to channel their violence against Obama’s enemies.

"Instead of doing drive-by shootings in their own neighborhoods, these young thugs will do beatings and murders of people ‘trying to escape’ — people who all seem to be leaders and members of groups that oppose Obama."

Utterly bonkers. And here there’s a movie coming out based on one of his books…which I will not be seeing. Ever.