Neurophilosopher Patricia Churchland appeared on The Colbert Report to discuss with the host some of the latest developments in neuroscience and what they shed on old philosophical questions. She had to break the news to him, a practicing Catholic, that he has no soul (because none of us do) and that our moral sense arises from the circuitry and chemical activity of the brain. It is a good interview. He actually asks some sharp questions, dealing with the kinds of concerns a religious person would have, and gives her time to respond rather than taking up a lot of the time which can be a failing of his.
(This clip aired on January 23, 2014. To get suggestions on how to view clips of The Daily Show and The Colbert Report outside the US, please see this earlier post. If the videos autoplay, please see here for a diagnosis and possible solutions.)