Not the ‘cell phones cause autism’ crap again

OMG, babies have thin skulls! They can be pierced!

That’s the kind of nonsense we get in bad popular science articles — a True Fact that is cited as demonstrating a real danger to children. Buzzfeed points to the sensationalist media hype over a terrible article that claims cell phones are warping babies innocent helpless brains.

The journal Child Development published what was described as a “review article” –an assessment of existing literature – by Cindy Sage and Ernesto Burgio. It was titled “Electromagnetic Fields, Pulsed Radiofrequency Radiation, and Epigenetics: How Wireless Technologies May Affect Childhood Development”, and was published in a “special section” of the journal addressing technology risks.

The paper got picked up by the UK national media. An article in the Express, published in May, asked: “Could wireless technology be causing MAJOR health problems in your children?”

It said: “Wireless mobile phones, laptops and tablets could be causing major health problems in children and contributing to autism and hyperactivity, a new study warns,” and said that these devices, “which even include baby monitors, emit radiation and electromagnetic fields that pierce thin skulls, harming memory, learning and other mental skills”.

However, a new paper published in the journal PeerJ by Dorothy Bishop, a professor of developmental psychology at the University of Oxford who specialises in developmental conditions such as autism, and David Robert Grimes, a medical physicist also at the University of Oxford, has issued severe doubts about the study. They said its claims are “devoid of merit” and “should [not be] given a veneer of legitimacy”.

The Child Development paper claimed that phones, Wi-Fi, and other sources of electromagnetic fields (EMFs) “are widely documented to cause potentially harmful health impacts that can be detrimental to young people”.

The actual article in Child Development isn’t quite that sensationalist, but it’s bad in other ways. As is usual in this kind of article about the horrors of electromagnetic radiation, I always wonder if, after they get rid of our cell phones, they’re planning to get rid of that great big thermonuclear-powered source of radiation and electromagnetic fields in the sky — after all, it’s silly to go after the piddling sources of feeble EMR while ignoring the many orders of magnitude greater zapper of rays that is bathing our whole planet in a seething stew of wavelengths and photons and rays and all that sciencey crap.

I wonder what the mechanism might be that causes autism in response to EMFs. This is always the problem with these kinds of ‘studies’ — they’re long on hypotheticals, and weak on the causal links that might be testable and might actually give some substance to the vapor. The Bishop and Grimes paper does a good job on dismantling their arguments there, too, because I was really annoyed when Sage and Burgio trot out their “Plausible Biological Mechanism for EMF/RFR Effects” and it’s…epigenetics. Epigenetics is the new buzzword that gets inserted in place of “magic” nowadays, and it’s getting obnoxious. You have to do real experiments and measurements of epigenetic phenomena to be able to make that claim — and simply noting that DNA repair is slower when your cells in culture are exposed to low-intensity non-thermal radiation, which might make them more prone to cancer, does not imply “epigenetics did it”. I don’t even know what they mean by epigenetics! It seems that whenever they observe an effect for which they have no causal mechanism, they just label it epigenetic and call that the mechanism, as if that explains anything.

Bishop and Grimes summarize it well.

Sage and Burgio make liberal use of epigenetic terminology, but in a nebulous and non-specific fashion, being deployed as an apparent deus ex machina to attribute negative health effects to WiFi in the absence of any evidence. Epigenetics is a term used to refer to the case where environmentally-induced modifications persist across generations, but Sage and Burgio treat it more as a synonym for gene-environment interaction. This usage is common among advocates of complementary and alternative medicine, but unhelpful as it confuses rather than clarifying the role of environmental effects.

Anyway, relax. There is no plausible mechanism for cell phones or WiFi to fry your baby’s brain, so go ahead, pierce their thin little skulls with radiation. I’m a big fan of holding babies close so that the infrared radiation you are emitting from your chest (more wattage than is coming out of your phone!) toasts their little heads with warmth. I think we humans have been doing that for a few hundred thousand years, so it’s probably not harmful. Probably. Studies pending.

Günter who?

I don’t know who Günter Bechley is, but apparently he writes for the Discovery Institute, and he despises me.

I despise the dogmatic and sometimes even fanatical stance of some evolutionists like P.Z. Myers (Pharyngula blog), Laurence Moran (Sandwalk blog), Jeffrey Shallit (Recursivity blog), Jerry Coyne (Why Evolution is True blog), freelance writer John Farrell, the anonymous coward behind The Sensuous Curmudgeon blog, and other infamous web activists against Intelligent Design and religion.

If you follow the link, you’ll discover he’s one of those people who thinks the theory is in imminent danger of collapsing, because scientists keep learning new things, and babbles about new discoveries in hominid evolution. Just two little problems there: the details of the timeline of human history are not the theory part of evolution, and a willingness to accommodate new evidence is a good thing.

I guess he’s just going to have to keep on despising me, but it’s OK when the despisers are so absurdly wrong.

Suspension of disbelief caught fire and exploded

I didn’t like the premiere episode of the new Star Trek at all. I was so repelled that I felt no desire at all to see the second — but I know, other people feel otherwise. Even some scientists are still enthusiastic. For instance, Jeremy Yoder lists all the bad biology in past and present episodes of the show, and still recommends it, even after the galactic fungus and space-hopping tardigrade story, which makes me nauseous to even listen to the video clip explaining it with outrageous technobabble. I guess his ability to suspend disbelief is far more robust than mine.

So, honestly, it’s hard to watch almost any episode of Star Trek without my biology-sense tingling. But here’s the thing: the bio-bollocks is often deeply entangled with what makes Trek great. The episode of Voyager in which two characters are temporarily transmuted into one touches on questions of personhood, and what makes us unique, self-determining individuals. The shape-shifting villains of Deep Space Nine created innumerable opportunities for stories about paranoia and power in wartime and the risks of trading freedom for security. The biological impossibility of Mr. Spock’s parentage makes him a touchstone for anyone who’s lived with dual identities or a sense of alienation from their community. The de-evolution virus … well, okay, that one I can’t justify. But by and large, when Star Trek has stretched and often broken the limits of biological realism, it’s done so to tell stories that are worth the telling — and that inspired many a nerdy kid to stick with science long enough to learn how fictional Star Trek really is.

I agree that the pseudoscience isn’t the point of a Star Trek story. I just feel like, if the writers cared, they could take the time to get the science right, and that good science wouldn’t detract from a good story.

Positional information and morphogens

Here we go again — I said I’d try to make a youtube video about developmental biology every week, and I’m keeping that promise. I’m thinking, though, that my last couple of efforts were too big and indigestible, weighing in at 40 minutes each, so I’m going to try instead to present brief introductions to basic biology, and see if those are more interesting to people. I aimed for 10 minutes, but hit 12 instead — sorry, I’m a college professor, wind me up and let me go and I won’t shut up.

Let me know if this format is easier to stomach, and suggestions are welcome.

I could take ’em

I watched that terrible Giant Robot Duel. They were slow, clumsy, and stupid, with nothing but ginned-up drama to add some fake excitement to cumbersome machines poking at each other in slow motion. It was like old television wrestling slowed down to a tenth of the usual speed.

At least I realized something. An old flabby guy in glasses, like me, could easily defeat these monsters. All I’d need is a pair of cable cutters to go in and hack random wires and tubes while they plod around, and victory! I’ll say this for the old FAF wrestling nonsense, I know that Rowdy Roddy Piper or Hulk Hogan or any random luchador would flatten me in a heartbeat and with a laugh. These robots were contrived and pathetic.

Also, we already have manned fighting robots. They just aren’t poorly designed to appear anthropoid and aren’t equipped with feeble weapons like paintball guns or chainsaws. Here’s one:

We’ve been working on battle bot technology for about a century now. These things aren’t pathetically awkward and inefficient and useless.

I also don’t think I could take an M1A2 with my aged nimbleness and some wire cutters.

I’d feel schadenfreude, except that it’s such a damn sad waste

Alternative medicines: they claim to cure all kinds of ailments, or at best they promise that they’re harmless supplements. Now here comes the data that says some herbal remedies are correlated with increased cancer risk.

According to a study published Wednesday in Science Translational Medicine, traditional components of herbal remedies used throughout Asia are widely implicated in liver cancers there. In Taiwan, for instance, 78 percent of 98 liver tumors sampled displayed a pattern of mutations consistent with exposure to herbs containing aristolochic acids (AAs). These are carcinogenic components found in a variety of centuries-old herbal remedies said to treat everything from snakebites to gout, asthma, and pain.

Because of their toxicity, some (but not all) of the herbs and plants known to contain AAs have been banned in Taiwan and other places. These flora tend to come from the genera Aristolochia (e.g., birthwort, pipevine) and Asarum (wild gingers). The Food and Drug Administration has also issued several warnings and advisories over AA-containing remedies.

Also relevant: patients who replace tested medicines with alternative crap have a 5x higher death rate within 5 years.

There’s a reason there are tested guidelines in place for careful, controlled studies of medicines, and why side-effects and long-term consequences are scrutinized thoroughly. What’s the point of a treatment for gout that works, hypothetically, if it increases your risk of liver cancer?

There are also reasons for ethical guidelines. Take, for example, this experimental vaccine for herpes that was designed by William Halford and backed by Peter Thiel. They bypassed IRB review; they ignored FDA guidelines; they carried out the tests on an island in the Caribbean, St Kitts, to bypass US oversight requirements. They injected 20 patients who really were suffering with serious, chronic herpes infections with a weakened virus, and got mixed results — for some it changed how subsequent expressed themselves, for others, it made the symptoms worse. The researchers failed to demonstrate either safety or efficacy.

And then, to make it even worse, Halford died, leaving the patients and the study in the hands of…who? No one. By abandoning responsible oversight, he’d left the legitimate biomedical authorities free of any obligation.

Maybe Peter Thiel will step forward and take responsibility for this botched and poorly designed experiment.

I can laugh at that idea, at least. But not at the desperate people who take bizarre alternative medicines or leap at terrible forlorn hope therapies.

The continuing saga of the scientific implosion of the Wansink lab

How can anyone be this sloppy?

Originally published in JAMA Pediatrics in 2012, the study found that children were more likely to choose apples over cookies during lunch when the apples had a sticker of Elmo. Both the original and the replacement claimed that the study included 208 students “ranging from 8 to 11 years old” at seven schools in upstate New York.

But, as confirmed to BuzzFeed News by the leader of the study, Cornell University professor Brian Wansink, the data was actually collected while observing kids 3 to 5 years old.

“We made a mistake in the age group we described in the JAMA article. We mistakenly reported children ranging from 8 to 11 years old; however, the children were actually 3 to 5 years old,” Wansink told BuzzFeed News by email.

As the “leader of the study”, you’d expect someone to have some vague idea of the approximate ages of the subject…you’d at least know whether the school you were testing at was a pre-school or an elementary school. This is what you’d expect of a guy who is great at churning out papers and grant proposals, but is a bumbling incompetent at the science. Unfortunately, most of the rewards of science go to those who excel at the first set of skills, while the second has a low priority.

Anti-vaxxers behaving badly

Another study has come out claiming a link between vaccinations and autism — and it has been retracted. The paper was deeply flawed in a lot of ways, but we can ignore the poor experimental design, the bad statistics, the cherry-picking of the data, and the funding from dubious sources, and focus entirely on one crystal clear concern: they faked their data. One of their figures is a jiggery-pokery jigsaw assemblage of gel bands copy-pasted into an image that bears little relationship to reality.

The principal investigator, Christopher Shaw, was confronted with these obvious, irrefutable facts of faked data, and he goes into an unconvincing song-and-dance of denial. He doesn’t know who could have done this or why, he says.

We don’t know how some images in the manuscript came to be altered. We investigated when the first suggestions came out in Pubpeer and confirmed that some of the images had indeed been manipulated. We don’t know by whom or why. The first author, Dr. Dan Li, denies doing anything wrong, but has not provided any information about this in spite of repeated questions from us. We are continuing to pursue these questions, but as she is now at another institution, we can’t force her to comply.

Those are outright lies. He knows. The figures for a paper do not simply manifest out of thin air — Shaw had to have discussed this illustration with Li. If he didn’t contribute directly to the paper himself, he is responsible for delegating the work. It’s got 4 authors on it; they had to have talked about the data, worked to interpret it, decided how these data supported their hypothesis, and put together a publishable story. The person who put so much remarkable effort into cobbling together a totally fake image had to have done so consciously — you don’t ‘accidentally’ make at least a dozen edits and reorganize the contents of an image in Photoshop.

Shaw also claims that the figures were not significant anyway. Then why publish it? This is another lie. They thought it was worth including in the paper, and someone went to considerable effort to mangle the data — why would they risk compromising their scientific integrity for a figure that they think doesn’t matter?

Faking data is the second most serious crime you can commit against science (the first would be ethics violations that do harm, which includes faking data). It is unforgivable. Retracting this paper is an inadequate response — the perpetrators ought to be fired, any grants rescinded, and there ought to be an asterisk, at least, on all of their published papers because their data is clearly untrustworthy. Two of the authors, Shaw and Tomljenovic, have a history of dubious work and past retractions. They still get published. The University of British Columbia is still defending them, which is unfortunate since it taints all the legitimate research done there.

Shaw is blaming others for his problems.

“Anti-vaccine” researcher is an ad hominem term tossed around rather loosely at anyone who questions any aspect of vaccine safety. It comes often from blogs and trolls, some of which/whom are thinly disguised platforms for the pharmaceutical industry… Anyone who questions vaccine safety to whatever degree gets this epithet.

This is nonsense. Imagine it’s true that there is a conspiracy against you, and swarming trolls are trying to destroy your reputation. What would you do? Would you be particularly careful to make your work above criticism, consulting with colleagues to get a thorough inspection of your data and interpretations before publishing them, or would you get so sloppy that you would eagerly publish an easily detectable manipulated figure?

Fire the lot of ’em. Forging data is such an egregious crime in science that it ought to warrant retraction of tenure.