Klotho (KL) is an interesting gene. It produces an enzyme which seems to be involved in repressing cellular senescence by regulating the p53 pathway, mouse mutations in these genes produce the symptoms of accelerated aging, and there are even a couple of known human alleles correlated with changes in longevity and coronary artery disease. The current research is at the level of basic science, though, asking how this gene product fits into the regulatory web that maintains cell states; it is not ready for any kind of medical work, I don’t even know how we would take advantage of the information to tinker with aging processes, and as far as I know, there are no clinical trials of any kind in the works. So it’s promising and is useful information, but it’s not at all ready or even approachable for medical use, yet.
That doesn’t stop the quacks, though!
A commercial quack operation called Homeovitality is taking advantage of a tiny bit of research (to create pseudo-scientific buzzwords) and people’s ignorance to market fake therapies. One among several is based on a smidgen of truth about the Klotho gene and a lot of fakery.
Homeovitality® is an entirely new concept in health promotion. It is designed to help people achieve and maintain different forms of nature’s “super-health” and stay healthy. For the first time ever, Homeovitality® helps everyone to benefit from new “cutting-edge” genetic and other scientific discoveries right now using a safe, natural non-pharmacological delivery system.
You may be wondering how they are taking advantage of “cutting-edge” research. Here’s how.
Because of Dr. Matsumara’s work and completion of the Human Genome Project, the complete DNA sequence of the KL gene has been worked out. Therefore, to target your KL gene, a DNA molecule was prepared that was identical in sequence to 273 base pairs of an active part of everyone’s KL gene. The sequence of the KL targeting molecule is as follows;
5′- ACTACCGCTT CTCCATCTCG TGGGCGCGAG TGCTCCCCAA TGGCAGCGCG GGCGTCCCCA ACCGCGAGGG GCTGCGCTAC TACCGGCGCC TGCTGGAGCG GCTGCGGGAG CTGGGCGTGC AGCCCGTGGT CACCCTGTAC CACTGGGACC TGCCCCAGCG CCTGCAGGAC GCCTACGGCG GCTGGGCCAA CCGCGCCCTG GCCGACCACT TCAGGGATTA CGCGGAGCTC TGCTTCCGCC ACTTCGGCGG TCAGGTCAAG TACTGGATCA CCA -3′.
The KL targeting molecule, as well as the others was prepared, purified and sequenced by one of Australia’s leading genetics laboratories.
So they get onto the easily accessed NIH site and get the gene sequence, and then they order a vial of the purified DNA from a commercial outfit (this is trivial: the NIH even includes a link to suppliers of cDNA clones).
I mean, really, just having a strand of DNA with the sequence of Klotho does nothing — it’s the action of the gene product in the cell that plays a subtle role in aging. What we need for a therapeutic use of this information is a way to regulate the activity of the protein in cells in a predictable way. So what does Homeovitality® have people do?
Drink a DNA solution? Are they insane? That’s just going to get broken down and do nothing, and besides, it’s not as if your body contains some shortage of Klotho genes — every cell in your body has a copy. Of course, even that objection is pointless, because you aren’t actually drinking any DNA. This is a homeopathic solution.
Homeovitality® products have also been succussed at each dilution stage so they will also help to promote desirable forms of hybrid vigour in a “like promotes like” mode of action involving some of the mechanisms (4) described by Dr. Kratz, (http://kulisz.com/how_does_homeopathy_work.htm).
Homeovitality® products are safe because firstly, they are used at similar dilutions to classical homeopathic disease remedies and secondly, hybrid vigour is a completely natural biological process that has been developed by nature over millions of years to enable all creatures to enjoy “super health” and disease resistance.
They’re selling bottles of water and pretending it’s medicine, with a cloud of pseudo-scientific hokum to justify it.
And here’s another sad fact: the creator of this snake-oil, Peter Kay, has a legitimate degree and a good collection of scientific publications to his name, some of them in topics with which I am familiar. None of them justify this homeopathic DNA nonsense. It looks like someone has realized that science doesn’t pay as well as grifting.