Back in 1939, Joseph Berkson made a bold statement.
I believe that an observant statistician who has had any considerable experience with applying the chi-square test repeatedly will agree with my statement that, as a matter of observation, when the numbers in the data are quite large, the P’s tend to come out small. Having observed this, and on reflection, I make the following dogmatic statement, referring for illustration to the normal curve: “If the normal curve is fitted to a body of data representing any real observations whatever of quantities in the physical world, then if the number of observations is extremely large—for instance, on an order of 200,000—the chi-square P will be small beyond any usual limit of significance.”
This dogmatic statement is made on the basis of an extrapolation of the observation referred to and can also be defended as a prediction from a priori considerations. For we may assume that it is practically certain that any series of real observations does not actually follow a normal curve with absolute exactitude in all respects, and no matter how small the discrepancy between the normal curve and the true curve of observations, the chi-square P will be small if the sample has a sufficiently large number of observations in it.Berkson, Joseph. “Some Difficulties of Interpretation Encountered in the Application of the Chi-Square Test.” Journal of the American Statistical Association 33, no. 203 (1938): 526–536.