May 13 2013

I’ll Bet A Million Dollars He’s Not A Terrorist

Federal agents arrested a suspicious traveler with an altered Saudi Arabian passport at Detroit Metro Airport over the weekend after discovering a pressure cooker in his luggage.

According to a criminal complaint filed today in U.S. District Court, the passenger, Hussain Al Khawahir initially told customs officers that he brought the pressure cooker for a nephew at the University of Toledo because pressure cookers are not sold in Saudi Arabia, the complaint said. The man then changed his story and admitted his nephew had purchased a pressure cooker in America before, but it “was cheap” and broke after the first use.

If this fucken dumshitte were really a terrorist planning to explode a pressure cooker bomb, he wouldn’t have flown into the motherfucken US with a goddamn motherfucken pressure cooker in his fucken luggage. He would have bought a motherfucken pressure cooker after he arrived at any of kajillions of houseware stores in every fucken city. Or if he is a terrorist, he’s the stupidest one to have every existed since forever.

May 12 2013

USA! USA! USA!


Happy Mothers’ Day, maybe — the U.S. is one of the worst places in the industrialized world to be a mother. That is, at least, according to a report published earlier this week by Save The Children. The NGO based its index on “the lifetime risk of maternal death, the under-five mortality rate, years of formal schooling, income per capita, and the participation of women in government.” The U.S. ranked 30th, according to the measure.

May 12 2013

w00t!

yippy!

May 12 2013

Festival Of Farfalle II: Tomato Cream

INGREDIENTS
one cup chopped white onion
six chopped garlic cloves
red pepper flakes
black pepper
salt
chopped tarragon
half cup dry white wine
large can crushed tomatoes (these were from New Jersey)
third of a cup heavy cream
olive oil
parmigiano reggiano

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Sautee the onions and garlic with red and black pepper until they are translucent and getting soft.

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Deglaze with the wine, adding some chopped tarragon. Reduce until alcohol is gone.

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Add the crushed tomatoes, bring to a simmer, and then continue to simmer on low with the lid off, stirring occasionally.

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Tomato sauce is nice and thick, after about 45 minutes.

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Throw the farfalle into the boiling salted water, and add the cream to the sauce, stirring well and continuing to simmer.

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When the farfalle are very molto al dente, add half a cup of pasta water to the sauce, throw in the drained pasta, and finish on medium high for two minutes or so.

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Oh, YEAH!!!

May 12 2013

Festival Of Farfalle I: Shrimp

INGREDIENTS
one pound shrimp
half pound farfalle
fucketonne chopped garlic
red chile pepper flakes
dried thyme
black pepper
half cup dry white wine
one cup clam juice
chopped cilantro
olive oil
parmigiano reggiano

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Sautee the shrimp until they are just barely cooked, remove from pan, and reserve.

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Sautee the garlic with red and black pepper and thyme until it is nice and toasty.

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Deglaze with the wine.

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Reduce until it all the alcohol is gone.

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Add the clam juice and some cilantro, and reduce while you boil the farfalle.

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When the farfalle are very molto al dente after boiling in salted water, add about a half cup of pasta water to the sauce, add the drained pasta, and finish on medium high for about two minutes.

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YUMMY!!!!!!!!!

May 11 2013

Crowdsourcing Science And Open Internet Peer Review

If you are crowdsourcing your science and relying on open Internet peer review to justify your science, then random douchebagges on the Internet *are* your peer reviewers. Reacting to them–even the douchey ones–like they are ignorant morons to be condescendingly beaten into submission with ad hominem arguments and accusations of bad faith is fucken stupid and counterproductive.

It is no more useful than the typical disgruntled NIH grant applicant with FACTUAL ERRORS OF BIASED AND IGNORANT REVIEWERS KILLED MY GRANT. At least some crowdsourcers seem to think that for some reason crowdsourcing and open Internet peer review is going to be different, but it isn’t. Like it or not, crowdsourcers are in the business of persuasion, and the sooner they wrap their minds around that fact–and give up on the “anyone who doesn’t see the genius of my approach is ignorant and/or biased and entire fields are scientifically bankrupt” gibberish–the greater the likelihood that they will succeed at their stated goals.

May 10 2013

Cheese Ponderable

Does it mean jacke fucken dicke other than “better and more expensive” when a cheese is branded “reserve”? Which is not meant as a complaint, because I am eating a fucken “gruyere reserve” right now that is blowing my fucken mind and it was expensive.

May 10 2013

Moby Dicke CHAPTER 19. The Prophet.

“Shipmates, have ye shipped in that ship?”

Queequeg and I had just left the Pequod, and were sauntering away from the water, for the moment each occupied with his own thoughts, when the above words were put to us by a stranger, who, pausing before us, levelled his massive forefinger at the vessel in question. He was but shabbily apparelled in faded jacket and patched trowsers; a rag of a black handkerchief investing his neck. A confluent small-pox had in all directions flowed over his face, and left it like the complicated ribbed bed of a torrent, when the rushing waters have been dried up.

“Have ye shipped in her?” he repeated.

“You mean the ship Pequod, I suppose,” said I, trying to gain a little more time for an uninterrupted look at him.

“Aye, the Pequod—that ship there,” he said, drawing back his whole arm, and then rapidly shoving it straight out from him, with the fixed bayonet of his pointed finger darted full at the object.

“Yes,” said I, “we have just signed the articles.”

“Anything down there about your souls?”

“About what?”

“Oh, perhaps you hav’n't got any,” he said quickly. “No matter though, I know many chaps that hav’n't got any,—good luck to ‘em; and they are all the better off for it. A soul’s a sort of a fifth wheel to a wagon.”

“What are you jabbering about, shipmate?” said I.

“HE’S got enough, though, to make up for all deficiencies of that sort in other chaps,” abruptly said the stranger, placing a nervous emphasis upon the word HE.

“Queequeg,” said I, “let’s go; this fellow has broken loose from somewhere; he’s talking about something and somebody we don’t know.”

“Stop!” cried the stranger. “Ye said true—ye hav’n't seen Old Thunder yet, have ye?”

“Who’s Old Thunder?” said I, again riveted with the insane earnestness of his manner.

“Captain Ahab.”

“What! the captain of our ship, the Pequod?”

“Aye, among some of us old sailor chaps, he goes by that name. Ye hav’n't seen him yet, have ye?”

“No, we hav’n't. He’s sick they say, but is getting better, and will be all right again before long.”

“All right again before long!” laughed the stranger, with a solemnly derisive sort of laugh. “Look ye; when Captain Ahab is all right, then this left arm of mine will be all right; not before.”

“What do you know about him?”

“What did they TELL you about him? Say that!”

“They didn’t tell much of anything about him; only I’ve heard that he’s a good whale-hunter, and a good captain to his crew.”

“That’s true, that’s true—yes, both true enough. But you must jump when he gives an order. Step and growl; growl and go—that’s the word with Captain Ahab. But nothing about that thing that happened to him off Cape Horn, long ago, when he lay like dead for three days and nights; nothing about that deadly skrimmage with the Spaniard afore the altar in Santa?—heard nothing about that, eh? Nothing about the silver calabash he spat into? And nothing about his losing his leg last voyage, according to the prophecy. Didn’t ye hear a word about them matters and something more, eh? No, I don’t think ye did; how could ye? Who knows it? Not all Nantucket, I guess. But hows’ever, mayhap, ye’ve heard tell about the leg, and how he lost it; aye, ye have heard of that, I dare say. Oh yes, THAT every one knows a’most—I mean they know he’s only one leg; and that a parmacetti took the other off.”

“My friend,” said I, “what all this gibberish of yours is about, I don’t know, and I don’t much care; for it seems to me that you must be a little damaged in the head. But if you are speaking of Captain Ahab, of that ship there, the Pequod, then let me tell you, that I know all about the loss of his leg.”

“ALL about it, eh—sure you do?—all?”

“Pretty sure.”

With finger pointed and eye levelled at the Pequod, the beggar-like stranger stood a moment, as if in a troubled reverie; then starting a little, turned and said:—”Ye’ve shipped, have ye? Names down on the papers? Well, well, what’s signed, is signed; and what’s to be, will be; and then again, perhaps it won’t be, after all. Anyhow, it’s all fixed and arranged a’ready; and some sailors or other must go with him, I suppose; as well these as any other men, God pity ‘em! Morning to ye, shipmates, morning; the ineffable heavens bless ye; I’m sorry I stopped ye.”

“Look here, friend,” said I, “if you have anything important to tell us, out with it; but if you are only trying to bamboozle us, you are mistaken in your game; that’s all I have to say.”

“And it’s said very well, and I like to hear a chap talk up that way; you are just the man for him—the likes of ye. Morning to ye, shipmates, morning! Oh! when ye get there, tell ‘em I’ve concluded not to make one of ‘em.”

“Ah, my dear fellow, you can’t fool us that way—you can’t fool us. It is the easiest thing in the world for a man to look as if he had a great secret in him.”

“Morning to ye, shipmates, morning.”

“Morning it is,” said I. “Come along, Queequeg, let’s leave this crazy man. But stop, tell me your name, will you?”

“Elijah.”

Elijah! thought I, and we walked away, both commenting, after each other’s fashion, upon this ragged old sailor; and agreed that he was nothing but a humbug, trying to be a bugbear. But we had not gone perhaps above a hundred yards, when chancing to turn a corner, and looking back as I did so, who should be seen but Elijah following us, though at a distance. Somehow, the sight of him struck me so, that I said nothing to Queequeg of his being behind, but passed on with my comrade, anxious to see whether the stranger would turn the same corner that we did. He did; and then it seemed to me that he was dogging us, but with what intent I could not for the life of me imagine. This circumstance, coupled with his ambiguous, half-hinting, half-revealing, shrouded sort of talk, now begat in me all kinds of vague wonderments and half-apprehensions, and all connected with the Pequod; and Captain Ahab; and the leg he had lost; and the Cape Horn fit; and the silver calabash; and what Captain Peleg had said of him, when I left the ship the day previous; and the prediction of the squaw Tistig; and the voyage we had bound ourselves to sail; and a hundred other shadowy things.

I was resolved to satisfy myself whether this ragged Elijah was really dogging us or not, and with that intent crossed the way with Queequeg, and on that side of it retraced our steps. But Elijah passed on, without seeming to notice us. This relieved me; and once more, and finally as it seemed to me, I pronounced him in my heart, a humbug.

May 09 2013

Dismantling Tired Arguments

If you find yourself “dismantling the same tired arguments” year after year in response to your advocacy for your scientific research program, thatte’s a *you* problem. It means thatte you are doing a shitte jobbe explaining why the fucke anyone should give a flying fucke about your shitte. Corollary: accusing people who raise those “tired arguments” anew of being ignorant or of reflecting some kind of bankruptcy of an entire field is shooting yourself in the fucken dicke.

May 09 2013

Additional Thoughts On Open Peer Review Of Ethan Perlstein’s Yeast Studies Of Sertraline

Scientists don’t respond to peer review critiques that propose alternative hypotheses to the ones they favor by whining like a college freshman whose heartfelt poetry assignment just got trashed that the professor “just doesn’t understand, maaan”. You put on your big-boy or big-girl scientist pants and address those alternative hypotheses by making arguments based on actual experiments–either already performed or proposed to be performed–that are capable of ruling them out.

In relation to the yeast studies of sertraline, an on-point critique of the proposed alternative hypotheses would involve well-established pharmacological controls. In particular, how does the dose-response curve of yeast to sertraline compare to the does-response curve to chemically similar compounds whose does-response curves for neural effects in mammals are greatly shifted?

For example, are there enantiomeric forms of sertraline that have well-separated dose-response curves for neural effects in mammals? I don’t know if there are, but if so, how do yeast respond to these enantiomeric forms? If not, are there other amphiphilic cations with similar detergent-like properties to sertraline, but with very different neural effects in mammals? How do yeast respond to these compounds?

How do yeast respond to basic laboratory detergents? Are the mutants isolated in the screen as resistant to 45 uM sertraline also resistant to other detergents?

And the fact that these yeast mutants in genes that regulate membrane cellular biochemistry and trafficking also affect cellular uptake of low concentrations of sertraline means nothing on its own. Nor does the fact that there is a cytoprotective effect at lower concentrations that is genotype-specific. The key question is whether these effects also occur for other chemically similar compounds whose does-response curves for neural effects in mammals are greatly shifted.

That is how you respond to a peer-review critique that proposes alternative hypotheses, not with generalized philosophical complaints, appeals to authority, and semantic whining about “what does ‘non-specific’ mean anyway, maaan?”

Here is the substantive bottom line: If the effects of sertraline on yeast are relevant to its effects on neurons because there are mechanistic similarities in how it influences cellular function in both cell types, then there will be parallels in the effects of chemical variants of sertraline on dose-response in these two systems. Compounds that exhibit altered effects in neurons should exhibit similarly altered effects on yeast, and compounds that exhibit relatively unaltered effects neurons should exhibit relatively unaltered effects on yeast.

And if these experiments–or other appropriate pharmacological controls–have been done, and the results rule out my alternative hypotheses, then great! I am happy to admit I am wrong and to consider my critique overcome. This is how big-boy/big-girl peer review works.

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