The Discovery Institute wants my money

royalflush

I got a begging email from our good friends at the Center for Science & Culture. They’re going to have to work a lot harder to persuade me.

Dear PZ:

Wait. Dear PZ? I’m having a tough time imagining any of those bozos addressing me as dear. But let us continue.

Intelligent design is a common sense idea. Research has shown that children intuitively recognize design in the world around them. You and I make design inferences every day. It has taken a long time for the scientific community to catch up with the kids. But that day is coming.

Intuitive and “common sense” assumptions are often wrong. You might enjoy these misconceptions children have about physics, for instance. I look forward to their new slogan: Intelligent Design: so simple, only a child would believe it. Except that it’s insulting to children.

The rest of the letter is all about the crap science they’ve been dumping on the public this year, and threatening to publish more.

For over 19 years, the Research & Scholarship Initiative of Discovery Institute’s Center for Science & Culture (CSC) has worked to build the scientific case for design and to winsomely communicate their research and scholarship to a broad audience.

Heh. This is the first time I’ve every seen the adverb “winsomely” applied to what the creationists do. I had to go to the Evolution News website to see an example of their winsome articles. Here’s one: Rubik’s Cube Is a Hand-Sized Illustration of Intelligent Design.

For those interested in explaining ID to people without a lot of memory work, the Rubik’s Cube can be a useful instructional aid. You don’t have to master the art of solving it. Save your sanity; just buy two cubes, and don’t touch the solved one. Lock it into a plastic case if you have to, so that you won’t have to try all 43 quintillion combinations in front of your audience. Or, rent a kid who can fix it in a few seconds.

Explain that the cube is a search problem. Take the scrambled one, and show how you want to get from that one to the solved one. You need a search algorithm. Which approach is more likely to find the solution — intelligent causes or unguided causes? The answer is obvious, but go ahead; rub it in. A robot randomly moving the colors around could conceivably hit on the solution by chance in short order with sheer dumb luck (1 chance in 43 x 1018), but even if it did, it would most likely keep rotating the colors right back out of order again, not caring a dime. It would take an intelligent agent to recognize the solution and stop the robot when it gets the solution by chance.

More likely, it would take a long, long time. Trying all 43 x 1018 combinations at 1 per second would take 1.3 trillion years. The robot would have a 50-50 chance of getting the solution in half that time, but it would already vastly exceed the time available (about forty times the age of the universe). If a secular materialist counters that there could be trillions of robots with trillions of cubes working simultaneously throughout the cosmos, ask what the chance is of getting any two winners on the same planet at the same place and time. The one concession blocks the other. And what in the materialist’s unguided universe is going to stop any robot when it succeeds? The vast majority will never succeed during the age of the universe.

Now rub it in. It would vastly exceed the age of the known universe for a robot to solve the cube by sheer dumb luck. How fast can an intelligent cause solve it? 4.904 seconds. That’s the power of intelligent causes over unguided causes.

Now really, really rub it in. The Rubik’s cube is simple compared to a protein. Imagine solving a cube with 20 colors and 100 sides. Then imagine solving hundreds of different such cubes, each with its own solution, simultaneously in the same place at the same time. If the audience doesn’t run outside screaming, you didn’t speak slowly enough.

Oh, man. So much wrong.

One problem with ID’s argument is that they are committed to the fallacy of a specified target for an evolutionary search. So the “goal” of evolution is to produce a human being, and given the 3+ billion years of chance and variation, and the multitude of different forms produced, I’ll agree: the likelihood of our specific form arising from a sea of single-celled organisms is extremely unlikely. But evolution doesn’t care; it doesn’t have a goal; it spawns endless different forms, so we get elephants and algae at the same time that we get, in one brief and fleeting moment of geological time, anthropoids.

One problem with their Rubik’s Cube example is that it does have a known goal: you’re supposed to get each side to a different solid color. Their single enshrined cube set to a single specific solution is a good example of the poverty of Intelligent Design creationism.

If I were to use Rubik’s Cube as a demonstration of how evolution works, I’d have to do something very different. We have about 20,000 genes, so I’d have to by 20,000 Rubik’s Cubes (not on a professor’s salary), and I’d set each one to a different arrangement. Much of it would be chance, but for some, I’d make a desultory effort. Can I get this one to display mostly green squares on one side? On this one I want three adjacent squares to be red. Another one has alternating yellow squares on one face. You get the idea — I want diversity, and I don’t have to work as hard or as narrowly to get it. I’d also just stroll through the house, tripping over these stupid Rubik’s Cubes everywhere, and occasionally twisting one.

That’s closer to evolution than the DI’s vision.

They’re always making this mistake of assuming the only correct solution is one pre-specified result. I really want to play poker with them: I’d tell them first that the goal of the game is get a Royal Flush, and they’d fold at every hand and I’d clean up with every feeble deal.

One other problem with their analogy is that they’re comparing the cube to the wrong thing. The more natural comparison is not to evolution, but to protein folding. Here’s this chain of amino acids, and you have to twist it into a specific conformation that will function…why, the numbers say this is nearly impossible! And math doesn’t lie!

Here’s a 1993 paper by Fraenkel, Complexity of Protein Folding, that says this.

It is believed that the native folded three-dimensional conformation of a protein is its lowest free energy state, or one of its lowest. It is shown here that both a two- and three-dimensional mathematical model describing the folding process as a free energy minimization problem is NP-hard. This means that the problem belongs to a large set of computational problems, assumed to be very hard (“conditionally intractable”). Some of the possible ramifications of this result are speculated upon.

All the mathematicians and computer scientists out there will recognize that word, NP-hard. This represents a computationally very difficult problem that isn’t easily solved (a Rubik’s Cube is not NP-hard, I don’t think–there are relatively simple algorithms that can solve it, although getting an optimal, minimum-number-of-moves solution might be harder — I haven’t been following the math.) Fraenkel explains the problem in words that will bring joy to the heart of every IDiot, as long as they don’t read the rest.

Each amino acid in a protein can adopt, on average, eight different conformations (Privalov, 1979). A relatively small protein, consisting of 100 amino acids, can thus potentially assume 8100 conformations.

Whoa — 8100 conformations is a much bigger number than 43 x 1018 combinations of the Rubik’s Cube that so impressed the Discovery Institute. I guess we’re done here. It’s impossible for any of my proteins to fold into a functional shape before the heat death of the universe, therefore there must be trillions of invisible tiny angels flitting about winsomely in my body, lovingly crafting DNA Polymerase II for me, cunningly assembling actin monomers into fibers, shuttling electrons about in my mitochondria with focused attention to every detail. I eagerly await the moment when the Discovery Institute lifts those 2 sentences from Fraenkel in their promotional literature.

I assume they’ll conveniently ignore the existence of the next two sentences.

Yet nature attains the native conformation in about 1 sec. (Note that the claim that nature assumes the global minimum free energy conformation in 1 sec is not equivalent to saying that it explores all the 8100 potential conformations in 1 sec!)

So protein folding is a much more difficult problem than solving a Rubik’s cube. The DI is dazzled by a human solving the cube in under 5 seconds, and thinks this demonstrates the superiority of intelligence over other natural causes. Yet the much more difficult problem is solved by the cell in under a second.

Point to physics, chemistry, and biology. Magic intelligence loses again.

Hey, do you think the writers at the Center for Science & Culture have a joke dictionary that defines “winsomely” as “stupidly”? That would make sense.

Making popcorn for the coming tardigrade wars

tardigrade

This could get interesting. I’ve seen a lot of stories about this recent paper on the tardigrade genome:

Horizontal gene transfer (HGT), or the transfer of genes between species, has been recognized recently as more pervasive than previously suspected. Here, we report evidence for an unprecedented degree of HGT into an animal genome, based on a draft genome of a tardigrade, Hypsibius dujardini. Tardigrades are microscopic eight-legged animals that are famous for their ability to survive extreme conditions. Genome sequencing, direct confirmation of physical linkage, and phylogenetic analysis revealed that a large fraction of the H. dujardini genome is derived from diverse bacteria as well as plants, fungi, and Archaea. We estimate that approximately one-sixth of tardigrade genes entered by HGT, nearly double the fraction found in the most extreme cases of HGT into animals known to date. Foreign genes have supplemented, expanded, and even replaced some metazoan gene families within the tardigrade genome. Our results demonstrate that an unexpectedly large fraction of an animal genome can be derived from foreign sources. We speculate that animals that can survive extremes may be particularly prone to acquiring foreign genes.

And here are a few of the follow-up stories in the popular press:

The Tardigrade, World’s Cutest Microscopic Animal, is Filled with Alien DNA

What the World’s Toughest Animal Is Really Made Of

Indestructible ‘Water Bears’ Have Really Weird Genomes

The authors are saying that about 18% of the tardigrade genome is a product of horizontal gene transfer…that they’re full of genes gathered up from bacteria, and that this was adaptive, playing a role in their ability to survive desiccation.

I have to say…I had my doubts. That seemed really unlikely, not only that they’d have a history of that much HGT, but that it could be assigned to functional roles. But OK, they published it, let’s see how it shakes out.

Here’s where it gets interesting: another paper has just come online that says it’s all an artifact. Tardigrades are tiny, on the order of a thousand cells, so it’s difficult to sample them for sequencing without also picking up lots of bacterial contamination. Here’s the abstract:

Tardigrades are meiofaunal ecdysozoans and are key to understanding the origins of Arthropoda. We present the genome of the tardigrade Hypsibius dujardini, assembled from Illumina paired and mate-pair data. While the raw data indicated extensive contamination with bacteria, presumably from the gut or surface of the animals, careful cleaning generated a clean tardigrade dataset for assembly. We also generated an expressed sequence tag dataset, a Sanger genome survey dataset and used these and Illumina RNA-Seq data for assembly validation and gene prediction. The genome assembly is ~130 Mb in span, has an N50 length of over 50 kb, and an N90 length of 6 kb. We predict 23,031 protein-coding genes in the genome, which is available in a dedicated genome browser at http://www.tardigrades.org. We compare our assembly to a recently published one for the same species and do not find support for massive horizontal gene transfer. Additional analyses of the genome are ongoing.

And their conclusion:

Our assembly, and inferences from it, conflict with a recently published draft genome (UNC) for what is essentially the same strain of H. dujardini. Our assembly, despite having superior assembly statistics, is ~120 Mb shorter than the UNC assembly. Our genome size estimate from sequence assembly is congruent with the values we obtained by direct measurement. We find 15,000 fewer protein-coding genes, and a hugely reduced impact of predicted HGT on gene content in H. dujardini. These HGT candidates await detailed validation. While resolution of the conflict between these assemblies awaits detailed examination based on close scrutiny of the raw UNC data, our analyses suggest that the UNC assembly is compromised by sequences that derive from bacterial contaminants, and that the expanded genome span, additional genes, and HGT candidates are likely to be artefactual.

This could get very interesting.

It’s probably a conspiracy by the Republican party to condition voters

I learned something heartbreaking this weekend. Despite thinking that I had raised her right, my daughter came right out and told me the horrible truth: she likes to watch football. She appreciates the strategy, she says. I tried to explain that it’s so boring, that it’s brief flurries of burly men bashing each other in between long sessions of inane “color commentary”, but she would have none of it. She’s too far gone.

And now I discover that Rebecca Watson is also a fan! What is this? A whole generation of young women corrupted?But at least she has a good argument against football.

The paper she cites is damning.

Public schools should end their football programs because of the high prevalence of concussions. Five to twenty percent of students experience at least one concussion in a season of play. Nine to twelve year old players experience an average of 240 head impacts per season; high school players average 650 head impacts per season. An initial football concussion increases the risk of a subsequent concussion three or four fold not simply for the balance of that season but for the following season as well. Catastrophic brain injuries, though rare, are far more common in high school and college players who have experienced a previous non-catastrophic concussion. The brains of children are more susceptible to long-term damage from concussion than adults. Although the frequency of concussion in football is about the same as in hockey, fifty times as many students play football than hockey; football causes far more brain injuries. The brain is an irreplaceable organ, the health of which is foundational for the ability to learn, socialize and for fully realizing life’s physical and vocational opportunities.

Time for the slippery slope game. If we’re going to end football programs for kids under 18, why are we going to support college football? That should go, too. And if we kill college football, there goes the farm that raises brain-damaged blocks of meat to batter each other in professional football. And if pro football dies, Texas will secede from the union!

And hey, this is true heresy around Minnesota, that fewer players play hockey is not an excuse to tolerate an equally brain-damaging sport. We’ll tear the country apart.

So, clearly, thousands of children with cognitive dysfunction, neuron injury, and lifelong cognitive impairment are a small price to pay.

…school football concussions are often followed by weeks of impaired school academic performance, memory disturbances, headaches and absenteeism. High school cheerleaders have impaired cognition for at least days after a single concussion even when claiming to be asymptomatic. Cognitive dysfunction or neuron injury occurs after repetitive mild to moderate athletic concussions; catastrophic injuries or instances of prolonged loss of consciousness are not required to cause such harm. Even when measured cognition returns to baseline, symptoms of concussion often persist. A season of collegiate play leads to persistent cognitive dysfunction that is roughly proportional to the magnitude of head impact. One study shows that greater later-life cognitive impairment in NFL players is correlated with exposure to competitive football before twelve years of age. Evidence about the effect of youth football is evolving but is sufficient to show that school football is likely to adversely affecting school performance in the short term and may, if the trauma is not stopped, may proceed to permanent cognitive dysfunction over the long term.

Botanical Wednesday: Plants for dinner

I’m hearing occasional gasps of disbelief at the notion of a vegan Thanksgiving, so clearly I need to show you something to make you salivate.

That’s just an example — we’re having something different — but honestly, you can have a tremendous variety of textures and flavors, all delicious, without killing an animal.

Also not shown: Lefse is vegetarian, don’t you know.

Well, it isn’t any worse than that Time-Life image of human evolution

At last, I understand human evolution. It’s all here in this painting.

ayn-rand-bokor-evolution

Working from bottom to top, we witness the ascent of man. First, Homo erectus discovers fire, and stares at a burning twig. This was easier than it sounds, since all he had to do was light it from the volcano erupting over his left shoulder (there’s always a volcano, and it’s always erupting, in these things). If anyone has ever gone on a camping trip with those atavistic boy scouts, you will recognize his expression.

Next, Neandertals invent rocks. Two rocks at once…it’s a triumph!

The next big leap: men invent shaving and art. The subtle revelation in this image is that Cro-Magnon men were also all bronies — notice that he’s drawing a pony.

Civilization arises! Our representative man has invented writing and hats. He has not yet invented shirts, however, and I suspect that what he’s writing is My Little Pony slash fiction. It takes time to progress.

Then, Aristotle. Man has forgotten how to shave. He has, at least, evolved to the point of having half a shirt — clearly, a transitional form. Of course, the most important thing is that he has invented Thinking, or at least, staring vacantly while scratching his neck. He could be thinking about My Little Pony, but at least he’s not being obvious about it anymore.

Darkness follows. The next two and a half thousand years are unimportant and nothing of consequence happens until, at last, with a coruscation of light beams, Ayn Rand invents planets and stars while scribbling Libertarian rape fantasies with Objectivist rationalizations.

In the next phase (not shown), humans worship the god-like Rand to the point of paying $14,000 for cheesy paintings that portray her as the pinnacle of evolution, and thus begins the Fall of Man.

I have to weep at this Art. It tells a grand tragic story.

How not to do research

Oh, man. What did I just read? It’s on medium.com, and it perfectly reflects the twistedly wonky and uneven character of that site — it’s a piece by techbros for techbros titled How San Francisco’s gender disparity affects the attractiveness pairings of couples.

It is truly, deeply, monumentally awful. It’s the work of a dude who knows how to use R, is happy to invent lots of numbers to feed into R, and is himself full up to the brim with unjustified assumptions that he never bothers to question. And apparently he got enough people remarking on how stupid his article was that he had to add a disclaimer:

There seems to have been quite a bit of misunderstanding stirred up by this article, so please read this disclaimer: this analysis makes absolutely no value judgements about how attractive men & women in SF are, or how attractive they should feel. I lay out all the simplifying assumptions and I’ve tried to explain that this is not how the real world works. Nor do I believe this is how the real world works. No sane human should heed any advice from this article. None of this has any basis in reality. It’s not supposed to. This is just a thought experiment about how one might build an economic model for dating with gender ratio imbalances. I’ve preserved the entirety of the original text below. There’s plenty of room for miscommunication because the assumptions are buried inside the text. That’s my fault. But I urge everyone to read the piece in its entirety before jumping to conclusions.

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The magical world of epigenetics

epigenome

Let me tell you the hard part about writing about epigenetics: most of your audience has no idea what you’re talking about, but is pretty sure that they can use it, whatever it is, to justify every bit of folk wisdom/nonsensical assumption that they have. So while you’re explaining how it’s a very real and important biological process that is essential for development and learning and behavior, half your readers are using the biology to confirm their biases about evolution and inheritance, and the other half already know all the basic stuff and want to get to the Evisceration of the Wrong, which is always the fun part anyway.

So I’ve split this post in two: there’s a section on the basics of what epigenetics is, and there’s a section on what epigenetics is not, and why. Read whatever part floats your boat.

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