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Category Archive: Molecular biology

Oct 07 2013

And the 2013 Nobel Prize in Physiology or Medicine goes to…

Randy Schekman and Thomas S├╝dhof for their work in vesicle trafficking. We’re working through metabolism in my cell biology course right now, but clearly when we get to translation and export of proteins in a few weeks, I’m going to have to put together a new lecture to cover this subject.

Sep 25 2013

What are tumor suppressor genes?

nf1gap

I’m trying to raise money for the The Leukemia & Lymphoma Society, and I promised to do a few things if we reached certain goals. I said I’d write a post explaining what tumor suppressor genes are, while wearing a pirate hat and nothing else, if we raised $5000. Shiver me timbers, I did! And …

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Sep 21 2013

What are oncogenes?

madpiratemyers

I’m trying to raise money for the The Leukemia &amp Lymphoma Society, and I promised to do a few things if we reached certain goals. I said I’d write a post explaining what oncogenes are, while wearing a pirate hat, if we raised $2500. So here you go, arrr. If you want more, go to …

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Aug 26 2013

Magic RNA editing!

old-wrecked-car-outback-australia-14466708

One of those wacky Intelligent Design creationists (Jonathan McLatchie, an arrogant ignoramus I’ve actually met in Scotland) has a theory, which is his, to get around that obnoxious problem of pseudogenes. Pseudogenes are relics, broken copies of genes that litter the genome, and when you’ve got a gang of ideologues who are morally committed to …

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Aug 07 2013

ENCODE has its defenders!

Worst evolution diagram ever

You know I was really pissed off at the crap ENCODE was promoting, that the genome was at least 80% functional and that there was no such thing as junk DNA. And there have been a number of better qualified scientists (like W. Ford Doolittle and Dan Graur and many others) who have stood up …

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Jul 11 2013

Short, sharp summary

Larry Moran has a simple list of the 5 basics you need to understand about junk DNA. It’s short and sweet; I’d like to see a creationist, who are often weirdly antagonistic to the whole idea of junk DNA, deal with these basic facts before they start ranting against the observations and conclusions. Genetic Load …

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Jun 13 2013

The Supreme Court decision on patentable genomes

I’m shocked. Just totally surprised. And it was unanimous — the Supreme Court determined that human genes cannot be patented. This is excellent news. Why is it a good decision? Because medical DNA analysis was turning into a patchwork of competing landgrabs. Sequencing technology is coming along so nicely that more and more diagnostic tools …

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Mar 23 2013

We need a sociologist of science…or a philosopher

yalejunk

There’s another paper out debunking the ENCODE consortium’s absurd interpretation of their data. ENCODE, you may recall, published a rather controversial paper in which they claimed to have found that 80% of the human genome was ‘functional’ — for an extraordinarily loose definition of function — and further revealed that several of the project leaders …

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Feb 22 2013

ENCODE gets a public reaming

I rarely laugh out loud when reading science papers, but sometimes one comes along that triggers the response automatically. Although, in this case, it wasn’t so much a belly laugh as an evil chortle, and an occasional grim snicker. Dan Graur and his colleagues have written a rebuttal to the claims of the ENCODE research …

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Feb 05 2013

Give that fish a hand!

Graphic abstract.eps

I have a bit of a peeve with a common analogy for the human genome: that it is the blueprint of the body, and that we can find a mapping of genes to details of our morphological organization. It’s annoying because even respectable institutions, like the National Human Genome Research Institute, use it as a …

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