“I listen to all these complaints about rudeness and intemperateness, and the opinion that I come to is that there is no polite way of asking somebody: have you considered the possibility that your entire life has been devoted to a delusion? But that’s a good question to ask. Of course we should ask that question and of course it’s going to offend people. Tough.” -Daniel Dennett
P.S. Thanks to Jerry Coyne for posting this quotation on his blog. I’d never heard it before, and am gobsmacked. That Dennett is one smart cookie.